CAS 59247-13-1

ganglioside GT1B dal cervello bovino

Descrizione:

Il ganglioside GT1b è un glicoesfingolipide complesso trovato prevalentemente nel tessuto nervoso, in particolare nel cervello dei mammiferi, compresi i bovini. È caratterizzato dalla sua struttura, che consiste in uno scheletro di ceramide legato a una porzione di carboidrato che include residui di acido sialico. Questo ganglioside svolge un ruolo cruciale nella segnalazione cellulare, nello sviluppo neuronale e nella modulazione della trasmissione sinaptica. Il GT1b è noto per il suo coinvolgimento in vari processi biologici, inclusa la neuroprotezione e il riconoscimento cellulare. La sua presenza nel cervello contribuisce alla formazione di zattere lipidiche, che sono essenziali per il corretto funzionamento delle proteine di membrana. Inoltre, i gangliosidi come il GT1b sono implicati in malattie neurodegenerative e sono studiati per le loro potenziali applicazioni terapeutiche. Il numero CAS 59247-13-1 identifica specificamente questo composto, facilitando il suo riconoscimento nella letteratura scientifica e nelle banche dati. In generale, il ganglioside GT1b è significativo nella neuroscienza e nella biochimica a causa della sua complessità strutturale e dell'importanza funzionale nelle interazioni cellulari all'interno del sistema nervoso.

Formula: C₈₈H₁₅₇N₅O₄₄

InChI: InChI=1/C88H157N5O44/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-56(107)92-37-51(45(101)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)124-80-66(113)65(112)70(54(42-98)127-80)129-82-69(116)77(136-87(84(120)121)35-46(102)57(89)72(132-87)61(108)49(105)38-94)71(55(43-99)128-82)130-79-60(93-44(3)100)75(63(110)52(40-96)125-79)131-81-68(115)76(64(111)53(41-97)126-81)135-86(83(118)119)34-47(103)59(91)74(134-86)67(114)78(117)137-88(85(122)123)36-48(104)58(90)73(133-88)62(109)50(106)39-95/h30,32,45-55,57-82,94-99,101-106,108-117H,4-29,31,33-43,89-91H2,1-3H3,(H,92,107)(H,93,100)(H,118,119)(H,120,121)(H,122,123)/b32-30+/t45?,46-,47-,48-,49?,50?,51?,52-,53-,54+,55-,57+,58+,59+,60-,61?,62?,63+,64+,65+,66+,67?,68-,69-,70+,71+,72+,73+,74+,75-,76+,77-,78?,79+,80+,81+,82+,86+,87+,88+/m0/s1

Sinonimi:

• Ganglioside, GT1
• GT(1)Ganglioside
• GT1b Ganglioside
• Ganglioside GT1b
• N-Acetylneuraminylgalactosyl-N-acetylgalactosaminyl -(N-acetylneuraminyl-N-acetylneuraminyl)galactosyl- glucosylceramide
• Polysialoganglioside
• Trisialoganglioside GT1b
• (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-4-[(2S,3S,4R,5R,6S)-4-[(2R,4S,5R,6R)-5-amino-6-[2-[(2R,4S,5R,6R)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-ethyl]-2-carboxy-4-hydroxy-tetrahydropyran-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-carboxylic acid

Ganglioside GT1b Mixture (sodium salt)

CAS: 59247-13-1

GT1b, a trisialoganglioside, binds neurotoxins and MCPyV VP1, inhibits IL-6, IL-10, IgG, IgM, IgA, and has C18:1/C20:1 sphingoid backbones.

Formula: C₉₅H₁₆₂N₅O₄₇₃Na

Colore e forma: Solid

Peso molecolare: 2195.27

Ref: TM-T36862

Trisialoganglioside GT1b NH4+ salt

CAS: 59247-13-1

Formula: Unspecified

Purezza: >98%

Colore e forma: Solid

Ref: 48-56-1105

GT1b-Ganglioside

CAS: 59247-13-1

Formula: C₉₅H₁₆₂N₅O₄₇·3Na

Purezza: ≥ 98%

Colore e forma: White to off-white powder

Peso molecolare: 2159.3

Ref: 7W-GC4593

GT1b-Ganglioside sodium

CAS: 59247-13-1

GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Formula: C₉₅H₁₆₅N₅O₄₈·xNa

Colore e forma: White Powder

Peso molecolare: 2,145.33 g/mol

Ref: 3D-OG03923

GT1b-Ganglioside ammonium

CAS: 59247-13-1

GT1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Formula: C₉₅H₁₆₅N₅O₄₈·xNH₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 2,145.33 g/mol

Ref: 3D-OG167138

Ganglioside GT1b trisodium salt

Prodotto controllato

CAS: 59247-13-1

Applications Ganglioside GT1b trisodium salt (bovine brain) is a glycosphingolipid neuroprotectant.

Formula: C₉₅H₁₆₂N₅Na₃O₄₇

Colore e forma: Neat

Peso molecolare: 2195.28

Ref: TR-G235078

Ganglioside GT1b

CAS: 59247-13-1

Formula: C₈₈H₁₅₇N₅O₄₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1989.1952799999976

Ref: IN-DA01CBD9