CAS 59973-80-7

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)benzilidene]-1H-indene-3-acido acetico

Descrizione:

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)benzilidene]-1H-indene-3-acido acetico, con il numero CAS 59973-80-7, è un composto organico sintetico caratterizzato dalle sue uniche caratteristiche strutturali. Contiene un atomo di fluoro, un gruppo metile e un gruppo metilsulfonile, contribuendo alla sua potenziale attività biologica. La struttura centrale dell'indene è notevole per le sue proprietà aromatiche, che possono influenzare la reattività del composto e le interazioni con obiettivi biologici. Questo composto probabilmente mostrerà una lipofilia moderata ad alta a causa delle sue regioni idrofobiche, il che può influenzare la sua solubilità e permeabilità nei sistemi biologici. La presenza del gruppo funzionale acido acetico suggerisce un potenziale per l'ionizzazione a pH fisiologico, influenzando la sua farmacocinetica. Inoltre, la configurazione (Z) indica un particolare arrangiamento geometrico attorno al doppio legame, che può influenzare significativamente l'attività biologica del composto e le sue interazioni. In generale, questo composto potrebbe essere di interesse nella chimica medicinale, in particolare nello sviluppo di farmaci mirati a specifiche vie biologiche.

Formula: C₂₀H₁₇FO₄S

InChI: InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key: InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N

SMILES: C(C(O)=O)C=1C=2C(/C(=C\C3=CC=C(S(C)(=O)=O)C=C3)/C1C)=CC=C(F)C2

Sinonimi:

• (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (Z)-
• Aposulind
• Aptosyn
• Exisulind
• Fgn-1
• Prevatac(former Brand Name)
• Prevatec
• Sulindac sulfone
• cis-5-Fluoro-2-methyl-1-[p-methylsulfonylbenzylidenyl]indene-3-acetic acid
• 5-Fluoro-2-methyl-1-[(Z)-4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
• Unii-K619iig2R9
• (Z)-5-Fluoro-2-Methyl-1-[[4-(Methylsulfonyl)phenyl]Methylene]-1H-indene-3-acetic Acid
• APTOSYN/EXISULIND
• Ccris 7242
• Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)
• Sulindac Impurity 2（Sulindac EP Impurity B）
• (Z)-Sulindac Sulfone
• Sulindac EP Impurity B/ Sulindac Related Compound B ((Z)-Sulindac Sulfone)
• (Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID
• Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3- (1642020)
• Sulindac EP Impurity B (Sulindac Sulfone)
• Sulindac USP Related Compound B

Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid)

CAS: 59973-80-7

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₂₀H₁₇FO₄S

Colore e forma: Yellow Crystalline Powder

Peso molecolare: 372.08316

Ref: 45-1642020

1H-Indene-3-acetic acid,5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 372.4100

Ref: IN-DA00EC0N

Exisulind

CAS: 59973-80-7

Exisulind

Purezza: ≥95%

Peso molecolare: 372.41g/mol

Ref: 54-BUP06388

Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Colore e forma: Yellow Solid

Peso molecolare: 372.41

Ref: 4Z-S-294

Sulindac EP Impurity B

Prodotto controllato

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Colore e forma: Neat

Peso molecolare: 372.41

Ref: 86-MM0624.02

(Z)-Sulindac Sulfone

CAS: 59973-80-7

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)

Formula: C₂₀H₁₇FO₄S

Colore e forma: Neat

Peso molecolare: 372.41

Ref: TR-S699225

Sulindac Sulfone-d6

Prodotto controllato

CAS: 59973-80-7

Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);

Formula: C₂₀H₁₁D₆FO₄S

Colore e forma: Neat

Peso molecolare: 378.45

Ref: TR-S699227

Sulindac sulfone

CAS: 59973-80-7

Sulindac sulfone is a nonsteroidal anti-inflammatory drug that belongs to the class of sulfones. It has been shown to inhibit the mcl-1 protein, which is involved in the mitochondrial apoptosis pathway. Sulindac sulfone inhibits prostaglandin E2 (PGE2) levels and mitochondrial membrane potential in vitro assays. Sulindac sulfone also has inhibitory properties against a number of enzymes including cyclooxygenase-2 (COX-2), lipoxygenases, phospholipases A2, and thromboxane synthase. These properties are responsible for its anti-inflammatory effects. Sulindac sulfone shows minimal toxicity due to its low bioavailability and lack of liver metabolism. This drug has been shown to have anticancer activity as well as an ability to inhibit infectious diseases such as Leishmania major and Helicobacter pylori.

Formula: C₂₀H₁₇FO₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 372.41 g/mol

Ref: 3D-FS27971

Sulindac EP Impurity B

CAS: 59973-80-7

Formula: C₂₀H₁₇FO₄S

Peso molecolare: 372.41

Ref: ST-EA-CP-S108002

Exisulind

CAS: 59973-80-7

Exisulind (CP248) triggers apoptosis via PKG activation, shows antitumor effects, and inhibits growth in various rodent cancer models.

Formula: C₂₀H₁₇FO₄S

Purezza: 97.94%

Colore e forma: Solid

Peso molecolare: 372.41

Ref: TM-T24051