CAS 60239-18-1

DOTA

Descrizione:

DOTA, o acido 1,4,7,10-tetraazaciclododecano-N,N',N'',N'''-tetraacetico, è un acido poliaminocarboxilico che funge da agente chelante, in particolare nella chimica di coordinazione e nelle applicazioni radiopharmaceuticali. La sua struttura presenta un telaio ciclico con quattro atomi di azoto e quattro gruppi acidi carbossilici, permettendogli di legarsi efficacemente a ioni metallici, come gallio, indio e lutetio. DOTA è noto per la sua stabilità e capacità di formare complessi forti, rendendolo prezioso nell'imaging medico e nella radioterapia mirata. Il composto è tipicamente utilizzato nella marcatura di biomolecole per la tomografia a emissione di positroni (PET) e la tomografia computerizzata a emissione di fotone singolo (SPECT). La solubilità di DOTA in acqua e la sua compatibilità con i sistemi biologici aumentano la sua utilità in varie applicazioni biochimiche. Inoltre, la sua capacità di formare complessi stabili con radionuclidi consente un targeting preciso nel trattamento del cancro, evidenziando la sua importanza sia nella ricerca che negli ambienti clinici. In generale, DOTA è un composto versatile con importanti implicazioni nei campi della chimica, della medicina e dello sviluppo radiopharmaceuticale.

Formula: C₁₆H₂₈N₄O₈

InChI: InChI=1/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

InChI key: InChIKey=WDLRUFUQRNWCPK-UHFFFAOYSA-N

SMILES: C(C(O)=O)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1

Sinonimi:

• 1,4,7,10-Tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane
• 1,4,7,10-Tetraazacyclodecane-1,4,7,10-tetraacetic acid
• 1,4,7,10-Tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic acid
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl)Tetraacetic Acid
• 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• Dota
• NSC 681107
• Tetraxetan
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
• TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)
• DOTA(M-140)
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid
• 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID
• 1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid
• Tetraxetan/radical
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
• TetraxetanuM
• 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA
• 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane
• 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA
• Tetraxetanum (DOTA)
• Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
• -1,4,7,10-tetrayl)tetraacetic acid(DOTA)
• TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID
• 4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
• 1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid
• 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Purezza: >97.0%(T)

Colore e forma: White to Almost white powder to crystaline

Peso molecolare: 404.42

Ref: 3B-T1875

1,4,7,10-Tetraazacyclo­dodecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA

CAS: 60239-18-1

1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA

Formula: C₁₆H₂₈N₄O₈

Purezza: min. 98%

Colore e forma: white pwdr.

Peso molecolare: 404.42

Ref: 08-07-1942

Tetraxetan

CAS: 60239-18-1

Heterocyclic compounds (excluding aromatic or modified aromatic) withnitrogen hetero-atom(s) only nesoi

Formula: C₁₆H₂₈N₄O₈

Colore e forma: White Off-White Powder

Peso molecolare: 404.19071

Ref: 45-1652158

DOTA

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 404.4155

Ref: IN-DA00E8U5

Tetraxetan

CAS: 60239-18-1

Tetraxetan

Purezza: 98%

Peso molecolare: 404.42g/mol

Ref: 54-OR74571

Tetraxetan

CAS: 60239-18-1

Colore e forma: Neat

Ref: 86-MM3916.00

Gadobutrol Impurity 9

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Peso molecolare: 404.42

Ref: 4Z-G-3113

Gadoteridol Impurity 2

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Peso molecolare: 404.42

Ref: ST-EA-CP-G4004

DOTA

Prodotto controllato

CAS: 60239-18-1

Stability Hygroscopic
Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.
References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),

Formula: C₁₆H₂₈N₄O₈

Colore e forma: Light Yellow

Peso molecolare: 404.42

Ref: TR-D535500

Tetraxetan

CAS: 60239-18-1

Purezza: 95%

Peso molecolare: 404.4200134

Ref: 10-F602191

Tetraxetan

CAS: 60239-18-1

Tetraxetan is a useful organic compound for research related to life sciences. The catalog number is T65143 and the CAS number is 60239-18-1.

Formula: C₁₆H₂₈N₄O₈

Colore e forma: Solid

Peso molecolare: 404.42

Ref: TM-T65143

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

CAS: 60239-18-1

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a metal chelator or radioligand that is used for the diagnosis of cancer. DOTA, as other analogous compounds such as NOTA, TETA and DTPA, has a high affinity for gadolinium and binds to integrin receptors on the surface of cancer cells. It can then be detected by nuclear magnetic resonance spectroscopy or computed tomography. This agent is also used in conjunction with other drugs to treat certain cancers. The most common use of DOTA is as a component of chemotherapy drugs such as docetaxel and cisplatin. DOTA has been shown to be biocompatible with human serum and metabolic response studies have been conducted in animals without any serious side effects. DOTA has shown to be an effective anti-cancer drug for solid tumors in animals and humans with minimal toxicity due to its coordination geometry.

Formula: C₁₆H₂₈N₄O₈

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 404.42 g/mol

Ref: 3D-FT58676