CAS 61-72-3

Cloxacillina

Descrizione:

Cloxacillina è un antibiotico penicillina semisintetico che viene utilizzato principalmente per trattare infezioni causate da stafilococchi produttori di penicilinasi. È caratterizzato dalla sua struttura a beta-lattame, che è essenziale per la sua attività antibatterica. Cloxacillina è efficace contro una gamma di batteri Gram-positivi, in particolare Staphylococcus aureus, ed è resistente alla degradazione da parte di alcune beta-lattamasi, rendendolo un'opzione preziosa nel trattamento di infezioni resistenti. Il composto viene tipicamente somministrato per via orale o endovenosa ed è noto per il suo profilo di tossicità relativamente basso. La sua farmacocinetica include una buona assorbimento dal tratto gastrointestinale, sebbene il cibo possa influenzare la sua biodisponibilità. Cloxacillina viene metabolizzato nel fegato ed escreto principalmente attraverso i reni. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, reazioni allergiche e, in rari casi, effetti più gravi come la tossicità epatica. Come con tutti gli antibiotici, è fondamentale utilizzare Cloxacillina in modo giudizioso per prevenire lo sviluppo di resistenza agli antibiotici.

Formula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

InChI key: InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N

SMILES: N(C(=O)C=1C(=NOC1C)C2=C(Cl)C=CC=C2)[C@H]3[C@@]4(N([C@@H](C(O)=O)C(C)(C)S4)C3=O)[H]

Sinonimi:

• (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(O-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimet hyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-(((3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
• 6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
• 6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
• 6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid
• Brl 1621
• Clossacillina
• Clossacillina [DCIT]
• Cloxacilina
• Cloxacilina [INN-Spanish]
• Cloxacillin [INN:BAN]
• Cloxacilline
• Cloxacilline [INN-French]
• Cloxacillinum
• Cloxacillinum [INN-Latin]
• Hsdb 3042
• Methocillin S
• Methylchlorphenylisoxazoryl-penicillin
• Orbenin Extra Dry Cow
• Syntarpen
• Unii-O6X5Qgc2Vb

Cloxacillin Sodium Salt Monohydrate

CAS: 61-72-3, 642-78-4, 7081-44-9

Formula: C₁₉H₁₇ClN₃NaO₅S·H₂O

Purezza: >98.0%(HPLC)

Colore e forma: White to Orange to Green powder to crystaline

Peso molecolare: 475.88

Ref: 3B-C2244

Cloxacillin 1000 µg/mL in Acetonitrile

Prodotto controllato

CAS: 61-72-3

Formula: C₁₉H₁₈ClN₃O₅S

Colore e forma: Single Solution

Peso molecolare: 435.8813

Ref: 04-A11692090AL-1000

Cloxacillin

CAS: 61-72-3

Cloxacillin, a β-lactamase inhibitor, tackles S. aureus inflammation and has an IC50 of 0.04 µM.

Formula: C₁₉H₁₈ClN₃O₅S

Colore e forma: Solid

Peso molecolare: 435.88

Ref: TM-T73058

Cloxacilline-13c4

CAS: 61-72-3

Cloxacillin is a sulfa drug that inhibits bacterial growth by binding to the 50S ribosomal subunit. It inhibits the synthesis of bacterial cell walls by binding to dextran sulfate and polymerase chain. Cloxacillin has been shown to have experimental solubility data in various biological samples, such as human serum and wastewater treatment. Cloxacillin has also been shown to be effective against Streptococcus pyogenes (Group A streptococci) and Staphylococcus aureus, which are two common causes of infectious diseases. Cloxacillin may be used in combination with vancomycin therapy or benzalkonium chloride for these infections.

Formula: C₁₉H₁₈ClN₃O₅S

Purezza: Min. 95%

Peso molecolare: 435.88 g/mol

Ref: 3D-FC175020

Oxacillin EP Impurity E

CAS: 61-72-3

Formula: C₁₉H₁₈ClN₃O₅S

Peso molecolare: 435.88

Ref: ST-EA-CP-O58005