CAS 61-72-3: Cloxacillina

Descrizione: Cloxacillina è un antibiotico penicillina semisintetico che viene utilizzato principalmente per trattare infezioni causate da stafilococchi produttori di penicilinasi. È caratterizzato dalla sua struttura a beta-lattame, che è essenziale per la sua attività antibatterica. Cloxacillina è efficace contro una gamma di batteri Gram-positivi, in particolare Staphylococcus aureus, ed è resistente alla degradazione da parte di alcune beta-lattamasi, rendendolo un'opzione preziosa nel trattamento di infezioni resistenti. Il composto viene tipicamente somministrato per via orale o endovenosa ed è noto per il suo profilo di tossicità relativamente basso. La sua farmacocinetica include una buona assorbimento dal tratto gastrointestinale, sebbene il cibo possa influenzare la sua biodisponibilità. Cloxacillina viene metabolizzato nel fegato ed escreto principalmente attraverso i reni. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, reazioni allergiche e, in rari casi, effetti più gravi come la tossicità epatica. Come con tutti gli antibiotici, è fondamentale utilizzare Cloxacillina in modo giudizioso per prevenire lo sviluppo di resistenza agli antibiotici.

Formula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

InChI key: InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N

SMILES: O=C(O)C1N2C(=O)C(NC(=O)C=3C(=NOC3C)C=4C=CC=CC4Cl)C2SC1(C)C

Sinonimi:

• (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(O-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimet hyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-(((3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
• 6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
• 6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
• 6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid
• Brl 1621
• Clossacillina
• Clossacillina [DCIT]
• Cloxacilina
• Cloxacilina [INN-Spanish]
• Cloxacillin [INN:BAN]
• Cloxacilline
• Cloxacilline [INN-French]
• Cloxacillinum
• Cloxacillinum [INN-Latin]
• Hsdb 3042
• Methocillin S
• Methylchlorphenylisoxazoryl-penicillin
• Orbenin Extra Dry Cow
• Syntarpen
• Unii-O6X5Qgc2Vb
• Cloxacillin

Cloxacillin Sodium Salt Monohydrate

CAS: 61-72-3642-78-4 7081-44-9

• Formula: C₁₉H₁₇ClN₃NaO₅S·H₂O
• Purezza: >98.0%(HPLC)
• Colore e forma: White to Orange to Green powder to crystaline
• Peso molecolare: 475.88

Cloxacillin 1000 µg/mL in Acetonitrile

CAS: 61-72-3

• Formula: C₁₉H₁₈ClN₃O₅S
• Colore e forma: Single Solution
• Peso molecolare: 435.8813

Cloxacillin

CAS: 61-72-3

Cloxacillin, a β-lactamase inhibitor, tackles S. aureus inflammation and has an IC50 of 0.04 µM.

• Formula: C₁₉H₁₈ClN₃O₅S
• Colore e forma: Liquid
• Peso molecolare: 435.88

Cloxacilline-13c4

CAS: 61-72-3

13C labeled

• Formula: C₁₉H₁₈ClN₃O₅S
• Purezza: Min. 95%
• Peso molecolare: 435.88 g/mol

Cloxacillin

CAS: 61-72-3

Cloxacillin is a semi-synthetic penicillin antibiotic that inhibits the growth of bacteria by binding to …

• Formula: C₁₉H₁₈ClN₃O₅S
• Purezza: Min. 95%
• Peso molecolare: 435.88 g/mol