CAS 61177-45-5

Clavulanato di potassio

Descrizione:

Clavulanato di potassio è un composto beta-lattamico che funge da potente inibitore delle enzimi beta-lattamasi, prodotte da alcuni batteri per conferire resistenza agli antibiotici beta-lattamici. È comunemente usato in combinazione con antibiotici penicillinici, come l'amoxicillina, per aumentarne l'efficacia contro ceppi batterici resistenti. La sostanza appare come una polvere cristallina bianca o bianco sporco ed è solubile in acqua, il che facilita il suo utilizzo nelle formulazioni farmaceutiche. Il suo meccanismo d'azione implica il legame irreversibile al sito attivo delle beta-lattamasi, impedendo così l'idrolisi degli antibiotici beta-lattamici e consentendo loro di esercitare i loro effetti antibatterici. Clavulanato di potassio è generalmente ben tollerato, sebbene possa causare effetti collaterali in alcuni individui, tra cui disturbi gastrointestinali. È importante notare che, sebbene migliori l'efficacia degli antibiotici, non possiede un'attività antibatterica significativa da solo. Come agente farmaceutico, è fondamentale utilizzare Clavulanato di potassio sotto supervisione medica per garantire un dosaggio appropriato e mitigare potenziali effetti avversi.

Formula: C₈H₉NO₅·K

InChI: InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/b4-1-;/t6-,7-;/m1./s1

InChI key: InChIKey=FERIANDDKNFRJI-JSYANWSFSA-N

SMILES: C(O)(=O)[C@@H]\1N2[C@](O/C1=C\CO)(CC2=O)[H].[K]

Sinonimi:

• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2α,3Z,5α)]-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-
• Brl 14151K
• Clavitesse
• Clavulanic acid potassium salt
• Potassium clavulanate
• Serdaxin
• potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

CAS: 61177-45-5

Formula: C₈H₈KNO₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 237.2511

Ref: IN-DA0035ID

Potassium clavulanate with microcrystalline cellulose

CAS: 61177-45-5

Formula: C₈H₈NO₅K

Purezza: Clavulanic acid: 38.3 - 45.0 %

Colore e forma: White or almost white powder

Peso molecolare: 237.25

Ref: 7W-GA1260

Potassium Clavulanate

CAS: 61177-45-5

Formula: C₈H₈NO₅·K

Colore e forma: White To Off-White Solid

Peso molecolare: 198.16 39.10

Ref: 4Z-C-328

Clavulanate:Cellulose

CAS: 61177-45-5

Clavulanate:Cellulose

Formula: C₈H₈NO₅·K

Colore e forma: white or almost white crystalline powder

Peso molecolare: 237.25g/mol

Ref: 54-BIC581

Clavulanic acid potassium

CAS: 61177-45-5

Formula: C₈H₈NO₅·K

Colore e forma: Neat

Peso molecolare: 237.25

Ref: 04-C11668545

Clavulanic Acid Potassium Salt in Cellulose (1:1 mixture)

CAS: 61177-45-5

Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formula: C₈H₈NO₅·K

Colore e forma: Mixture

Peso molecolare: 237.25

Ref: TR-C563751

Clavulanic Acid Potassium Salt

CAS: 61177-45-5

Stability Hygroscopic, Temperature sensitive
Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formula: C₈H₈NO₅·K

Colore e forma: Light Yellow To Dark Brown

Peso molecolare: 237.25

Ref: TR-C563750

Potassium clavulanate - 1:1 mixture with silicon dioxide

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formula: C₈H₈NO₅·K

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 237.25 g/mol

Ref: 3D-FP30769

Clavulanate potassium

CAS: 61177-45-5

Clavulanate potassium,β-Lactamase inhibitor with antibiotic activity.

Formula: C₈H₈KNO₅

Colore e forma: Solid

Peso molecolare: 237.25

Ref: TM-T67431

Potassium clavulanate (40%) : silicon dioxide mixture

CAS: 61177-45-5

Formula: C₈H₈KNO₅

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 237.252

Ref: 10-F237796

Potassium clavulanate - 1:1 mixture with cellulose, Antibiotic for Culture Media Use Only

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls.

Formula: C₈H₈KNO₅

Purezza: Min. 95.0 Area-%

Peso molecolare: 237.25 g/mol

Ref: 3D-W-105420

Potassium clavulanate

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls. Potassium clavulanate is also used as an antimicrobial agent for blood culture technique and antimicrobial treatment.

Formula: C₈H₈NO₅·K

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 237.25 g/mol

Ref: 3D-FP10878

Potassium clavulanate - 1:1 mixture with cellulose

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formula: C₈H₈NO₅·K

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 237.25 g/mol

Ref: 3D-FP16197