CAS 62572-94-5

O-desmetilmetoprololo

Descrizione:

O-desmetilmetoprololo, con il numero CAS 62572-94-5, è un composto chimico che è un derivato del metoprololo, un noto beta-bloccante utilizzato principalmente nel trattamento di condizioni cardiovascolari come l'ipertensione e le aritmie. Questo composto presenta una struttura modificata in cui un gruppo metossilico è rimosso, risultando in proprietà farmacologiche alterate rispetto al suo composto genitore. O-desmetilmetoprololo è caratterizzato dalla sua capacità di interagire con i recettori beta-adrenergici, sebbene la sua affinità e efficacia possano differire da quelle del metoprololo. Il composto è tipicamente un solido bianco a bianco sporco, solubile in solventi organici, e ha un peso molecolare moderato. La sua struttura chimica include un anello fenolico e una catena laterale alifatica, che contribuiscono alla sua attività biologica. Come metabolita del metoprololo, O-desmetilmetoprololo può svolgere un ruolo nella farmacocinetica e farmacodinamica complessive del farmaco, influenzando i risultati terapeutici e gli effetti collaterali nei pazienti. Ulteriori studi vengono spesso condotti per comprendere i suoi effetti biologici specifici e la sua potenziale importanza clinica.

Formula: C₁₄H₂₃NO₃

InChI: InChI=1S/C14H23NO3/c1-11(2)15-9-13(17)10-18-14-5-3-12(4-6-14)7-8-16/h3-6,11,13,15-17H,7-10H2,1-2H3

InChI key: InChIKey=CUKXSBOAIJILRY-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(CCO)C=C1

Sinonimi:

• (±)-4-[2-Hydroxy-3-(isopropylamino)propoxy]phenylethyl alcohol
• (±)-O-Demethylmetoprolol
• 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneethanol
• Benzeneethanol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
• H 105/22
• O-Desmethyl Metoprolol
• O-Desmethylmetoprolol
• Sl 80-0088

O-Desmethylmetoprolol (1-(4-(2-hydroxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol)

CAS: 62572-94-5

Amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters, salts thereof, nesoi

Formula: C₁₄H₂₃NO₃

Colore e forma: White Off-White Solid

Peso molecolare: 253.16779

Ref: 45-1A03310

Metoprolol EP Impurity H (Betaxolol EP Impurity B)

CAS: 62572-94-5

Formula: C₁₄H₂₃NO₃

Colore e forma: White To Off-White Solid

Peso molecolare: 253.34

Ref: 4Z-M-0812

(2RS)-1-[4-(2-Hydroxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol

Prodotto controllato

CAS: 62572-94-5

Formula: C₁₄H₂₃NO₃

Colore e forma: Neat

Peso molecolare: 253.34

Ref: 86-MM0027.10

Betaxolol EP Impurity B

CAS: 62572-94-5

Formula: C₁₄H₂₃NO₃

Peso molecolare: 253.34

Ref: ST-EA-CP-B33002

O-Desmethyl Metoprolol

Prodotto controllato

CAS: 62572-94-5

Impurity Metoprolol EP Impurity H / Betaxolol EP Impurity B
Applications O-Desmethyl Metoprolol (Metoprolol EP Impurity H) is a metabolite of Metoprolol.
References Lennard, M.S., et al.: Br. J. Clin. Pharmacol., 14, 713 (1982), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 36, 320 (1984),

Formula: C₁₄H₂₃NO₃

Colore e forma: White To Off-White

Peso molecolare: 253.34

Ref: TR-D292073

O-Desmethyl metoprolol

CAS: 62572-94-5

O-Desmethyl metoprolol is an active metabolite of metoprolol. It has an inhibitory effect on beta-adrenergic receptors and acts as a vasodilator. O-Desmethyl metoprolol is formed by the action of cytochrome P450 on the parent drug, which has a strong acidic nature and is easily soluble in water. This metabolite can be detected in urine samples using a chromatographic method with detection sensitivity of 1 ng/mL. The stereoselectivity of the parent drug and its active metabolite is different, with the former being more selective for beta1 receptors while the latter is more selective for beta2 receptors. O-Desmethyl metoprolol may have clinical relevance because it was found to decrease blood pressure in hypertensive patients when given at doses that are much lower than those needed for its parent drug. The concentration of this metabolite in plasma was found to be proportional to dosage level and kinetic data suggest

Formula: C₁₄H₂₃NO₃

Purezza: Min. 95%

Peso molecolare: 253.34 g/mol

Ref: 3D-FD21293

Metoprolol EP Impurity H

CAS: 62572-94-5

Formula: C₁₄H₂₃NO₃

Peso molecolare: 253.34

Ref: ST-EA-CP-M17008

O-Desmethyl Metoprolol

CAS: 62572-94-5

O-Desmethyl metoprolol, a metabolite of metoprolol, acts as a β1-adrenergic receptor (β1-AR) antagonist. This compound is produced through the metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6.

Formula: C₁₄H₂₃NO₃

Colore e forma: Solid

Peso molecolare: 253.342

Ref: TM-T85293