CAS 630420-16-5

Asunaprevir

Descrizione:

Asunaprevir è un farmaco antivirale utilizzato principalmente nel trattamento delle infezioni da virus dell'epatite C (HCV). Funziona come un agente antivirale ad azione diretta, specificamente un inibitore della proteasi, che interferisce con il processo di replicazione virale inibendo l'enzima proteasi NS3/4A, essenziale per il ciclo vitale del virus. La formula chimica di Asunaprevir riflette la sua struttura complessa, che include più gruppi funzionali che contribuiscono alla sua attività farmacologica. Viene generalmente somministrato in combinazione con altri agenti antivirali per aumentare l'efficacia e ridurre il rischio di resistenza. Asunaprevir è caratterizzato dalla sua moderata solubilità nei solventi organici e dalla relativamente bassa solubilità in acqua, il che può influenzare la sua biodisponibilità. La sostanza è generalmente ben tollerata, anche se può avere effetti collaterali, tra cui affaticamento e disturbi gastrointestinali. Il suo sviluppo rappresenta un significativo progresso nel trattamento dell'epatite C, in particolare per i pazienti con genotipi specifici del virus. Il meccanismo d'azione di Asunaprevir e il suo ruolo nella terapia combinata evidenziano l'importanza di strategie antivirali mirate nella gestione delle infezioni virali.

Formula: C₃₅H₄₆ClN₅O₉S

InChI: InChI=1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H,39,42)(H,40,44)/t19-,21-,25+,27-,35-/m1/s1

InChI key: InChIKey=XRWSZZJLZRKHHD-WVWIJVSJSA-N

SMILES: N(C(=O)[C@H]1N(C([C@@H](NC(OC(C)(C)C)=O)[C@](C)(C)C)=O)C[C@H](OC=2C3=C(C(OC)=CN2)C=CC(Cl)=C3)C1)[C@@]4(C(NS(=O)(=O)C5CC5)=O)[C@H](C=C)C4

Sinonimi:

• (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-<span class="text-smallcaps">L</smallcap>-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-<smallcap>L</span>-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide
• 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
• 1-[[N-tert-Butoxycarbonyl-<span class="text-smallcaps">L</smallcap>-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-<smallcap>L</span>-prolyl]amino]-N-(cyclopropylsulfonyl)-(1R,2S)-2-vinylcyclopropane-1-carboxamide
• 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide
• Bms 650032
• Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-<span class="text-smallcaps">L</smallcap>-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-<smallcap>L</span>-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-
• Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-
• L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, (4R)-
• Sunvepra
• (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide
• Asunaprevir (BMS-650032)
• Asunaprevir

(1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide

CAS: 630420-16-5

Formula: C₃₅H₄₆ClN₅O₉S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 748.2858

Ref: IN-DA0039UQ

Asunaprevir

CAS: 630420-16-5

Asunaprevir

Purezza: ≥98%

Peso molecolare: 748.29g/mol

Ref: 54-BUP09612

Asunaprevir

CAS: 630420-16-5

Asunaprevir (BMS-650032) is an effective hepatitis C virus (HCV) NS3 protease inhibitor.

Formula: C₃₅H₄₆ClN₅O₉S

Purezza: 99.34% - 99.8%

Colore e forma: Solid

Peso molecolare: 748.29

Ref: TM-T4474

Asunaprevir

CAS: 630420-16-5

A competitive inhibitor of HCV NS3/4A protease that blocks viral replication. Efficacious in treating HCV-infected patients in combination with daclatasvir. Asunaprevir-resistant replicons are sensitive to NS5A replication complex inhibitor, suggesting potential combination therapy.

Formula: C₃₅H₄₆ClN₅O₉S

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 748.29 g/mol

Ref: 3D-FA64945

Asunaprevir

Prodotto controllato

CAS: 630420-16-5

Applications Asunaprevir is an inhibitor of the viral enzyme serine protease HCV NS3. Also functions as a second generation NS3/4A protease inhibitor used in the treatment of hepatitis C.
References Takehara, T., et al.: Igaku no Ayumi, 255, 1155 92015); Kalaghatgi, P., et al.: PLoS One, 11, 5 (2016)

Formula: C₃₅H₄₆ClN₅O₉S

Colore e forma: Neat

Peso molecolare: 748.29

Ref: TR-A788753