CAS 637-07-0

Clofibrato

Descrizione:

Clofibrato è un composto sintetico classificato come un fibrato, utilizzato principalmente come agente riduttore dei lipidi nel trattamento dell'iperlipidemia. La sua formula chimica è C12H15ClO3 e presenta una struttura ad anello aromatico clorurato, che contribuisce alle sue proprietà farmacologiche. Clofibrato funziona attivando i recettori attivati dai proliferatori dei perossisomi (PPAR), portando a un aumento dell'ossidazione degli acidi grassi e a una riduzione dei livelli di trigliceridi nel flusso sanguigno. Viene tipicamente somministrato per via orale ed è noto per la sua capacità di ridurre i livelli di colesterolo, in particolare le lipoproteine a bassa densità (LDL) e i trigliceridi, mentre potenzialmente aumenta i livelli di lipoproteine ad alta densità (HDL). Tuttavia, il suo uso è diminuito a causa di preoccupazioni riguardanti effetti collaterali, inclusi disturbi gastrointestinali e potenziale tossicità epatica. Clofibrato è anche associato a un aumento del rischio di calcoli biliari. Di conseguenza, viene spesso sostituito da nuovi agenti con profili di sicurezza migliorati. Nonostante il suo uso clinico ridotto, rimane un composto significativo nello studio del metabolismo lipidico e della salute cardiovascolare.

Formula: C₁₂H₁₅ClO₃

InChI: InChI=1/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI key: InChIKey=KNHUKKLJHYUCFP-UHFFFAOYSA-N

SMILES: O(C(C(OCC)=O)(C)C)C1=CC=C(Cl)C=C1

Sinonimi:

• 2-(4-Chlorophenoxy)isobutyric acid ethyl ester
• 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester
• Abitrate
• Amotril
• Anparton
• Apolan
• Arteriosan
• Artevil
• Ateculon
• Ateriosan
• Atheropront
• Atromid S
• Atromidin
• Ay 61123
• Azionyl
• Bioscleran
• Cartagyl
• Cinnarizine
• Claripex
• Claripex CPIB
• Clobren SF
• Clofibrat
• Clofibrato
• Clofinit
• Cpib
• Ecpib
• Epib
• Ethyl (p-chlorophenoxy) isobutyrate
• Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate
• Ethyl 2-(4-Chlorophenoxy)-2-Methylpropionate
• Ethyl 2-(4-chlorophenoxy)isobutyrate
• Ethyl 2-(p-chlorophenoxy)-2-methylpropionate
• Ethyl 2-(p-chlorophenoxy)isobutyrate
• Ethyl clofibrate
• Ethyl p-chlorophenoxyisobutyrate
• Ethyl α-(4-chlorophenoxy)-α-methylpropionate
• Ethyl α-(4-chlorophenoxy)isobutyrate
• Ethyl α-(p-chlorophenoxy)-α-methylpropionate
• Ethyl α-(p-chlorophenoxy)isobutyrate
• Hyclorate
• Ici 28257
• Lipavil
• Lipavlon
• Lipomid
• Liprinal
• Miscleron
• Misclerone
• Neo-Atromid
• Normet
• Normolipol
• Nsc 79389
• Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, ethyl ester
• Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester
• Recolip
• Regelan
• Serotinex
• Sklerepmexe
• Sklero-Tablinene
• Sklerolip
• Skleromexe
• Ticlobran
• Xyduril
• p-Chlorophenoxyisobutyric acid ethyl ester
• CLOFIBRATE
• 19 more names available
• 2-(p-Chlorophenoxy)isobutyric acid ethyl ester
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ETHYL ESTER
• CLOFIBRINIC ACID ETHYL ESTER
• Acetic acid, (p-chlorophenoxy)dimethyl-, ethyl ester
• alpha-(p-chlorophenoxy)isobutyricacid,ethylester
• CLOFIBRIC ACID ETHYL ESTER
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOIC ACID ETHYL ESTER
• 2-(4-chlorophenoxy)-2-methyl-propanoicaciethylester
• 2-(4-chlorophenoxy)-2-methyl-propionicaciethylester
• 2-(p-chlorophenoxy)-2-methyl-propionicaciethylester
• alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester

Clofibrate, 95+%

CAS: 637-07-0

It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agon

Formula: C₁₂H₁₅ClO₃

Purezza: 95+%

Peso molecolare: 242.7

Ref: 02-J60342

CLOFIBRATE CRS

CAS: 637-07-0

CLOFIBRATE CRS

Formula: C₁₂H₁₅ClO₃

Peso molecolare: 242.6987

Ref: 41-C2300000

Clofibrate liquid

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Peso molecolare: 242.70

Ref: 7W-GL9707

Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

CAS: 637-07-0

Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

Purezza: 98%

Peso molecolare: 242.6987g/mol

Ref: 54-OR26850

Clofibrate-d4

CAS: 637-07-0

Formula: C₁₀H₇ClO₃D₄

Peso molecolare: 246.73

Ref: 4Z-C-242

Clofibrate

CAS: 637-07-0

Clofibrate

Purezza: ≥98%

Peso molecolare: 242.7g/mol

Ref: 54-BUP17771

Clofibrate

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Purezza: >98.0%(GC)

Colore e forma: Colorless to Light yellow to Light orange clear liquid

Peso molecolare: 242.70

Ref: 3B-C0941

Clofibrate

Prodotto controllato

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Colore e forma: Neat

Peso molecolare: 242.70

Ref: 86-MM1934.00

Clofibrate

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Colore e forma: Neat

Peso molecolare: 242.70

Ref: 04-C11682000

Clofibrate

CAS: 637-07-0

Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.

Formula: C₁₂H₁₅ClO₃

Purezza: 98.77%

Colore e forma: Oil Liquid

Peso molecolare: 242.70

Ref: TM-T1298

Clofibrate RS

CAS: 637-07-0

Colore e forma: Colorless - Slightly Yellow Liquid Clear Liquid

Ref: 2K-1049000021

Clofibrate

Prodotto controllato

CAS: 637-07-0

Applications Antilipemic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Metz, G., et al.: Arzneim.-Forsch., 27, 1173 (1977), Hassan, A.M., et al.: Anal. Profiles Drug Subs., 11, 197 (1982),

Formula: C₁₂H₁₅ClO₃

Colore e forma: Colourless

Peso molecolare: 242.70

Ref: TR-C586910

Clofibrate

CAS: 637-07-0

Clofibrate is a lipid-lowering agent that is used for the treatment of hyperlipidemia. It is a non-selective inhibitor of fatty acid synthesis and has been shown to inhibit cancer cell growth in vitro. Clofibrate inhibits tumor cell proliferation and induces apoptosis, which may be due to its ability to inhibit protein synthesis in cancer cells. This drug also suppresses the growth of breast cancer cells by inhibiting their ability to proliferate.

Formula: C₁₂H₁₅ClO₃

Purezza: Min. 95%

Colore e forma: Colorless Clear Liquid

Peso molecolare: 242.7 g/mol

Ref: 3D-FC20499

Clofibrate

CAS: 637-07-0

M01536 - Clofibrate

Formula: C₁₂H₁₅ClO₃

Purezza: 98%

Colore e forma: Liquid

Peso molecolare: 242.7

Ref: 10-M01536

Clofibrate 100 µg/mL in Acetonitrile

CAS: 637-07-0

Formula: C₁₂H₁₅ClO₃

Colore e forma: Single Solution

Peso molecolare: 242.70

Ref: 04-A11682000AL-100