CAS 637-32-1

Cloridrato di proguanil

Descrizione:

Cloridrato di proguanil è un farmaco antimalarico utilizzato principalmente nella prevenzione e nel trattamento della malaria. È un composto sintetico che appartiene alla classe dei biguanidi. La sostanza è caratterizzata dalla sua forma di polvere cristallina bianca a bianco sporco, solubile in acqua e con un sapore leggermente amaro. Cloridrato di proguanil funge da profarmaco, essendo metabolizzato nel fegato nella sua forma attiva, cicloguanil, che inibisce la diidrofolato reduttasi, un enzima cruciale per la sintesi del folato nel parassita della malaria. Questa azione interrompe la capacità del parassita di riprodursi e sopravvivere all'interno dell'ospite. Il composto ha un profilo di tossicità relativamente basso, rendendolo adatto per l'uso in varie popolazioni, comprese le donne in gravidanza e i bambini. Inoltre, è spesso usato in combinazione con altri agenti antimalarici per migliorare l'efficacia e ridurre il rischio di sviluppo di resistenza. Come per qualsiasi farmaco, è essenziale considerare i potenziali effetti collaterali e controindicazioni quando si prescrive o si utilizza Cloridrato di proguanil.

Formula: C₁₁H₁₇Cl₂N₅

InChI: InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

InChI key: InChIKey=SARMGXPVOFNNNG-UHFFFAOYSA-N

SMILES: N(C(NC(NC(C)C)=N)=N)C1=CC=C(Cl)C=C1.Cl

Sinonimi:

• 1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride
• 1-[N′-(4-Chlorophenyl)carbamimidamido]-N-(propan-2-yl)methanimidamide hydrochloride
• 1-{(1E)-amino[(4-chlorophenyl)amino]methylidene}-2-(1-methylethyl)guanidine hydrochloride
• 3359 Rp
• Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
• Chloroguanide hydrochloride
• Chloroquanil
• Diguanyl
• Drinupal
• Drinupal hydrochloride
• Guanatol
• Guanatol hydrochloride
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Hydrochloride (1:1)
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N′-(1-methylethyl)-, monohydrochloride
• M 4888
• Paludrine
• Paludrine hydrochloride
• Palusil
• Palusil hydrochloride
• Proguanil HCL
• Rp 3359
• Sn 12,837
• Tirian
• Tirian hydrochloride
• chlorguanidehydrochloride
• Proguanil Hydrochloride (200 mg)
• drinupalhydrochloride
• Paludrin
• m4888
• PROGUANIL HYDROCHLORIDE
• n-4-chlorophenyl-n(sup5)-isopropyldiguanidehydrochloride
• Chlorguanid
• N1-(4-Chlorophenyl)-N5-isopropylbiguanide
• 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
• 3359rp
• sn12,837
• guanatolhydrochloride
• Chlorguanide Hydrochloride3
• palusilhydrochloride
• chloroguanidinehydrochloride
• N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride
• PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
• paludrinehydrochloride
• ChlorguanideHCl
• chloroguanidehydrochloride

Proguanil Hydrochloride

CAS: 637-32-1

Colore e forma: Neat

Ref: 61-FOR0840.00

PROGUANIL HYDROCHLORIDE CRS

CAS: 637-32-1

PROGUANIL HYDROCHLORIDE CRS

Formula: C₁₁H₁₇Cl₂N₅

Peso molecolare: 290.1922

Ref: 41-Y0001901

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Formula: C₁₁H₁₆ClN₅HCl

Purezza: 99.6%

Colore e forma: White Crystalline Powder

Peso molecolare: 289.0861

Ref: 47-297

PROGUANIL FOR SYSTEM SUITABILITY CRS

CAS: 637-32-1

PROGUANIL FOR SYSTEM SUITABILITY CRS

Formula: C₁₁H₁₇Cl₂N₅

Colore e forma: White. Crystalline Powder.

Peso molecolare: 290.1922

Ref: 41-Y0001885

Proguanil Hydrochloride

CAS: 637-32-1

Aromatic imines and their derivatives, salts thereof

Formula: C₁₁H₁₆ClN₅·HCl

Colore e forma: White Off-White Crystalline Powder

Peso molecolare: 253.10942

Ref: 45-1568040

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Purezza: ≥98%

Peso molecolare: 290.19g/mol

Ref: 54-BUP14518

Proguanil Hydrochloride

CAS: 637-32-1

Proguanil Hydrochloride

Purezza: 97%

Peso molecolare: 290.19g/mol

Ref: 54-OR1023733

Proguanil Hydrochloride

Prodotto controllato

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·ClH

Colore e forma: Neat

Peso molecolare: 290.19

Ref: 86-MM0840.00

Proguanil hydrochloride

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·HCl

Peso molecolare: 290.19

Ref: 7W-GL3057

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.

Formula: C₁₁H₁₇Cl₂N₅

Purezza: 98.34% - 98.39%

Colore e forma: Solid

Peso molecolare: 290.19

Ref: TM-T4382

Chlorguanide Hydrochloride

Prodotto controllato

CAS: 637-32-1

Formula: C₁₁H₁₆ClN₅·ClH

Colore e forma: White

Peso molecolare: 290.19

Ref: TR-C329500

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride is a drug used to treat malaria. It is a prodrug that is activated in the liver by hepatic esterases and converted to chloroguanide. Proguanil hydrochloride binds to DNA-dependent RNA polymerase, which inhibits transcription and replication of bacterial DNA. This drug also has effects on cardiac cells and can worsen congestive heart disease. Proguanil hydrochloride has been shown to interact with other drugs, such as acetaminophen, phenytoin, and warfarin, which can result in serious side effects. Proguanil hydrochloride is not active against some types of bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₁₁H₁₇Cl₂N₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 290.19 g/mol

Ref: 3D-FC19929

Chlorguanide-d6 Hydrochloride

Prodotto controllato

CAS: 637-32-1

Applications Chlorguanide-d6 Hydrochloride, is a labeled analogue of Chlorguanide (C329500), used as Antimalarial.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmidt., et al.: J. Pharmacol. Exp. Ther., 90, 233 (1947), Cortese, J., et al.: J. Infect. Dis., 186, 999 (2002), Lim, P., et al.: Antimicrob. Agents Chemother., 47, 87 (2003), Sidhu, A., et al.: Mol. Microbiol., 57, 913 (2005),

Formula: C₁₁H₁₁D₆Cl₂N₅

Colore e forma: Neat

Peso molecolare: 296.23

Ref: TR-C329503