CAS 63968-64-9

Artemisinina

Descrizione:

Artemisinina è una lattone sesquiterpenica con la formula chimica C15H22O5, derivata principalmente dalla pianta di assenzio dolce, Artemisia annua. È rinomata per le sue potenti proprietà antimalariche ed è un componente chiave nelle terapie combinate a base di Artemisinina (ACT) utilizzate per trattare la malaria. Il composto presenta un ponte endoperossido unico, che è cruciale per la sua attività biologica. Artemisinina mostra una solubilità moderata in solventi organici come etanolo e cloroformio, ma ha una solubilità limitata in acqua. Il suo meccanismo d'azione implica la generazione di specie reattive dell'ossigeno dopo attivazione da parte dell'eme, portando alla distruzione dei parassiti della malaria. Artemisinina è generalmente ben tollerato, anche se può causare effetti collaterali come nausea e vertigini in alcuni pazienti. A causa della sua origine naturale e della sua efficacia, la ricerca continua a ottimizzare i suoi derivati e a migliorare le sue proprietà farmacologiche. Inoltre, studi in corso stanno esplorando le sue potenziali applicazioni oltre la malaria, inclusi i suoi effetti su vari tipi di cancro e altre malattie.

Formula: C₁₅H₂₂O₅

InChI: InChI=1/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14+,15-/m1/s1

InChI key: InChIKey=BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(OC1=O)[H])[H]

Sinonimi:

• (+)-Arteannuin
• (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• (3S,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (5aS,6R,8aS,9R,12S)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-
• 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• ARTIVeda
• Artemef
• Artemisine
• Artemisinine
• Hc 101A
• Huanghuahaosu
• NSC 369397
• PulmoHeal
• Qing Hau Sau
• Qing Hau Su
• Qinghaosu
• Qinghosu
• [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• Artemisinin
• Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
• ARTEANUIN
• (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar*)-(+)-methyl
• Artemisinin Qinghaosu/ [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• ARTEMISININ (QINGHAOSU)
• SWEET WORMWOOD
• artemisiaannual.,extract
• ARTEMETHER
• 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tri
• ArteMisinin, 98%, froM ArteMisia annua L.
• qinghausau
• ARTEMISININ 99%
• 3,13-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)one,(ctahydro-3,6,9-trimethyl-,[3R-(3α,5αβ,6β,8αβ,9α,12β,12αR*)]-
• Arteannuin99%
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• Artemisinine,98%
• QHS
• Astemisinin
• Arteannuin, Qinghaosu
• ARTEMISIA P E
• QINGHAOSA
• octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(
• ALPHA BETA ARTEMISININ
• Quinghaosu
• qinghausu
• ArteMisinin, froM ArteMisia annua
• 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(+)
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3 ,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• ARTEMISIA ANNUA
• Artemisine，Artemisinin，Arteannuin
• Artemisia annual L Ext.

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purezza: >97.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 282.34

Ref: 3B-A2118

Artemisinin, 98%

CAS: 63968-64-9

Artemisinin inhibits angiogenesis by down-regulating HIF-1 and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio.

Formula: C₁₅H₂₂O₅

Purezza: 98%

Colore e forma: Crystals or crystalline powder, White

Peso molecolare: 282.34

Ref: 02-J65406

ARTEMISININ RS

CAS: 63968-64-9

ARTEMISININ RS

Formula: C₁₅H₂₂O₅

Colore e forma: Powder

Peso molecolare: 282.3322

Ref: 41-ICRS43857

Artemisinin

CAS: 63968-64-9

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₁₅H₂₂O₅

Colore e forma: White Off-White Solid

Peso molecolare: 282.14672

Ref: 45-1042747

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 282.3322

Ref: IN-DA00IBB0

Artemisinin

CAS: 63968-64-9

Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.

Formula: C₁₅H₂₂O₅

Purezza: 99.77% - 99.87%

Colore e forma: Crystalline Solid

Peso molecolare: 282.33

Ref: TM-T0392

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to off-white crystalline powder

Peso molecolare: 282.33

Ref: 7W-GP0718

Artemisinin

CAS: 63968-64-9

Artemisinin

Purezza: ≥95%

Peso molecolare: 282.33g/mol

Ref: 54-BUP16845

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Peso molecolare: 282.34

Ref: 4Z-A-309

Artemisinin

CAS: 63968-64-9

Colore e forma: Neat

Ref: 86-MM0803.00

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Purezza: 95%~99%

Peso molecolare: 282.336

Ref: BP-BP0197

Artemisinin

CAS: 63968-64-9

Artemisinin

Formula: C₁₅H₂₂O₅

Purezza: 97%

Colore e forma: white crystalline needles

Peso molecolare: 282.33g/mol

Ref: 54-BIA4320

Artemisinin

CAS: 63968-64-9

Lactone

Formula: C₁₅H₂₂O₅

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 282.34

Ref: 5G-89484

Artemisinin

CAS: 63968-64-9

Artemisinin is a sesquiterpene lactone, which is derived from the plant Artemisia annua, commonly known as sweet wormwood. This compound is isolated through a series of extraction and purification processes from the plant's leaves and flowers. Artemisinin exerts its pharmacological effect through a novel mode of action that involves endoperoxide bridges, which interact with intracellular iron to generate free radicals. These reactive species subsequently damage vital biomolecules within Plasmodium parasites, effectively inhibiting their ability to thrive and reproduce.

Formula: C₁₅H₂₂O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 282.33 g/mol

Ref: 3D-FA09640

Artemisinin-d4

Prodotto controllato

CAS: 63968-64-9

Formula: C₁₅D₄H₁₈O₅

Colore e forma: Neat

Peso molecolare: 286.357

Ref: TR-A777503

Artemisinin-13C-D3

Prodotto controllato

CAS: 63968-64-9

Formula: CC₁₄D₃H₁₉O₅

Colore e forma: Neat

Peso molecolare: 286.343

Ref: TR-A777504

Artesunate IP Impurity B

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Peso molecolare: 282.34

Ref: ST-EA-CP-A93012

Artemisinin

CAS: 63968-64-9

Formula: C₁₅H₂₂O₅

Colore e forma: White to Off-White Solid

Peso molecolare: 282.33

Ref: TR-A777500