CAS 64-73-3

Cloridrato di demeclociclina

Descrizione:

Cloridrato di demeclociclina è un antibiotico ad ampio spettro appartenente alla classe delle tetracicline, utilizzato principalmente per trattare varie infezioni batteriche. È caratterizzato dalla sua capacità di inibire la sintesi proteica nei batteri legandosi alla subunità ribosomiale 30S, impedendo così la crescita e la riproduzione dei microrganismi. Questo composto viene tipicamente somministrato per via orale ed è noto per la sua efficacia contro una gamma di batteri gram-positivi e gram-negativi. Cloridrato di demeclociclina è utilizzato anche nel trattamento di condizioni come l'acne e alcuni tipi di infezioni causate da batteri resistenti. Oltre alle sue proprietà antibatteriche, è stato utilizzato nella gestione di condizioni come la secrezione inappropriata dell'ormone antidiuretico (SIADH) grazie alla sua capacità di indurre diabete insipido nefrogenico. La sostanza è generalmente ben tollerata, ma può causare effetti collaterali come disturbi gastrointestinali e fotosensibilità. Come altre tetracicline, è controindicata nei bambini e nelle donne in gravidanza a causa dei potenziali effetti sullo sviluppo delle ossa e dei denti.

Formula: C₂₁H₂₁ClN₂O₈·ClH

InChI: InChI=1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI key: InChIKey=GVSJQNRGSCOSNJ-KBHRXELFSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C([C@H]3O)=C(Cl)C=CC4O)[H])[H].Cl

Sinonimi:

• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
• 6,10,12,12A-Pentahydroxy-1,11-Dioxo-Ydro-Monohydrochloride
• 6-Demethyl-7-chlorotetracycline hydrochloride
• 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
• 7-Chloro-4-Dimethylamino-3,6,10,12,12A-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydro-Naphthacene-2-Carboxamide Hydrochloride
• 7-Chloro-6-Demethyltetracycline Hydrochloride
• Clortetrin
• Declomycin
• Declomycin hydrochloride
• Declomycinhydrochloride
• Demeclocycline
• Demethylchlorotetracycline hydrochloride
• Demethylchlorotetracyclinehydrochloride
• Demethylchlortetracyclinehydrochloride
• Demetraciclina
• Detravis
• Ledermycin hydrochloride

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is used as an antibiotic related to tetracycline and produced by streptomyces aureofaciens, and used to maintain effective blood levels for longer periods of time, used as a fluorescent bone-labeling agent in bone histomorphometry. This Thermo Scientific Chemicals brand

Formula: C₂₁H₂₁ClN₂O₈•HCl

Peso molecolare: 501.32

Ref: 02-J63102

Demeclocycline Hydrochloride

CAS: 64-73-3

Colore e forma: Neat

Ref: 61-FOR0636.00

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 64-73-3

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₁H₂₂Cl₂N₂O₈

Colore e forma: Yellow. Powder.

Peso molecolare: 501.314

Ref: 41-Y0001707

DEMECLOCYCLINE HYDROCHLORIDE CRS

CAS: 64-73-3

DEMECLOCYCLINE HYDROCHLORIDE CRS

Formula: C₂₁H₂₂Cl₂N₂O₈

Colore e forma: Yellow. Powder.

Peso molecolare: 501.314

Ref: 41-D0300000

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Formula: C₂₁H₂₁ClN₂O₈HCl

Purezza: 90.2%

Colore e forma: Yellow

Peso molecolare: 500.07532

Ref: 47-789

Demeclocycline Hydrochloride

CAS: 64-73-3

Tetracyclines and their derivatives; salts thereof

Formula: C₂₁H₂₁ClN₂O₈·HCI

Colore e forma: Yellow Crystalline Powder

Peso molecolare: 501.31

Ref: 45-1170000

7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride

CAS: 64-73-3

Formula: C₂₁H₂₂Cl₂N₂O₈

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 501.3140

Ref: IN-DA0039UL

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline HCl (Declomycin), a tetracycline with 7-Cl & 6-CH₃, has prolonged blood levels due to slower excretion.

Formula: C₂₁H₂₁ClN₂O₈·HCl

Purezza: 96.21% - 99.14%

Colore e forma: Yellow Crystalline Powder Solid

Peso molecolare: 501.32

Ref: TM-T1400

Demeclocycline HCl

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·HCl

Colore e forma: Yellow Solid

Peso molecolare: 464.86 36.46

Ref: 4Z-D-721

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

CAS: 64-73-3

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

Purezza: 90%

Peso molecolare: 501.31g/mol

Ref: 54-OR1030500

Demeclocycline hydrochloride

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·HCl

Purezza: 90.0 - 102.0 % (dried basis)

Colore e forma: Yellow powder

Peso molecolare: 501.32

Ref: 7W-GA7186

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Purezza: ≥95%

Peso molecolare: 501.32g/mol

Ref: 54-BUP17020

PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol

Prodotto controllato

CAS: 101342-45-4, 14206-58-7, 179471-95-5, 2058-46-0, 23313-80-6, 24390-14-5, 41411-66-9, 64-72-2, 64-73-3, 64-75-5

Colore e forma: Colourless

Ref: 04-A30000035ME

Demeclocycline Hydrochloride

Prodotto controllato

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·ClH

Colore e forma: Neat

Peso molecolare: 501.31

Ref: 86-MM0636.00

Demeclocycline hydrochloride

Prodotto controllato

CAS: 64-73-3

Formula: C₂₁H₂₁ClN₂O₈·ClH

Colore e forma: Neat

Peso molecolare: 501.31

Ref: 04-C12128000

Demeclocycline Hydrochloride

CAS: 64-73-3

Applications An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.This compound is a contaminant of emerging concern (CECs).
References Jilka, R., et al.: J. Clin. Invest., 104, 439 (1999), Hauge, E; Bone, 28, 556 (2001), Dobnig, H., et al.: J. Clin. Endocrinol. Metab., 90, 3970 (2005),

Formula: C₂₁H₂₁ClN₂O₈·ClH

Colore e forma: Light Yellow To Yellow

Peso molecolare: 501.31

Ref: TR-D230725

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is a tetracycline antibiotic that binds to the tetracycline receptor and inhibits bacterial protein synthesis. Demeclocycline hydrochloride has been shown to be effective against many types of bacteria, including those that are resistant to other antibiotics such as methicillin or vancomycin. Demeclocycline hydrochloride has been used in the treatment of skin cancer and also has anti-inflammatory properties. Demeclocycline hydrochloride is a hydrophobic molecule with a metal chelating ability that can be used for wastewater treatment.

Formula: C₂₁H₂₁ClN₂O₈·ClH

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 501.31 g/mol

Ref: 3D-FD20979

Demeclocycline hydrochloride

CAS: 64-73-3

Purezza: 90%

Peso molecolare: 501.3099976

Ref: 10-F869293