CAS 64-77-7

Tolbutamide

Descrizione:

Tolbutamide è un farmaco della classe delle sulfoniluree utilizzato principalmente nella gestione del diabete mellito di tipo 2. Funziona stimolando la secrezione di insulina dalle cellule beta pancreatiche, abbassando così i livelli di glucosio nel sangue. Chimicamente, Tolbutamide è caratterizzato dalla sua formula molecolare, che include un gruppo sulfonilico e un anello aromatico, contribuendo alla sua attività farmacologica. Viene tipicamente presentato come una polvere cristallina bianca o bianco sporco, con una solubilità relativamente bassa in acqua, il che può influenzare la sua assorbimento e biodisponibilità. Il composto ha un punto di fusione moderato ed è stabile in condizioni normali, anche se deve essere conservato lontano dalla luce e dall'umidità per mantenere la sua efficacia. Tolbutamide viene metabolizzato nel fegato e i suoi effetti possono variare in base a fattori individuali del paziente, inclusa la funzione renale. Come con qualsiasi farmaco, può avere effetti collaterali, tra cui ipoglicemia e disturbi gastrointestinali, e deve essere usato sotto supervisione medica.

Formula: C₁₂H₁₈N₂O₃S

InChI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

InChI key: InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N

SMILES: S(NC(NCCCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Sinonimi:

• 1-Butyl-3-(4-methylphenyl)sulfonylurea
• 1-Butyl-3-(p-methylphenylsulfonyl)urea
• 1-Butyl-3-(p-tolylsulfonyl)urea
• 1-Butyl-3-tosylurea
• 3-(p-Tolyl-4-sulfonyl)-1-butylurea
• 3-Butyl-1-(4-methylbenzenesulfonyl)urea
• Aglicid
• Arkozal
• Artosin
• Artozin
• Benzenesulfonamide, N-[(Butylamino)Carbonyl]-4- Methyl-
• Butamid
• Butamide
• D 860
• Diaben
• Diabetamid
• Diabetol
• Diabuton
• Diasulfon
• Dolipol
• Glyconon
• Hls 831
• Ipoglicone
• Mobenol
• N-(4-Methylbenzene) sulfonyl-N'-butylurea
• N-(4-Methylbenzenesulfonyl)-N'-butylurea
• N-(4-Methylphenylsulfonyl)-N'-butylurea
• N-(Sulfonyl-p-methylbenzene)-N'-n-butylurea
• N-(p-Methylbenzenesulfonyl)-N'-butylurea
• N-(p-Tolylsulfonyl)-N'-butylcarbamide
• N-Butyl-N'-(4-methylphenylsulfonyl)urea
• N-Butyl-N'-(P-Tolylsulfonyl)-Harnstoff
• N-Butyl-N'-(p-tolylsulfonyl)urea
• N-Butyl-N'-p-toluenesulfonylurea
• N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
• N-n-Butyl-N'-tosylurea
• Nsc 23813
• Nsc 87833
• Orabet
• Oralin
• Orezan
• Orinase
• Orinaz
• Oterben
• Pramidex
• Rastinon
• Tolbusal
• Tolbutamid
• Tolbutamida
• Toluina
• Tolumid
• Tolumide
• Toluvan
• U 2043
• Urea, 1-butyl-3-(p-tolylsulfonyl)-

Tolbutamide, 98%

CAS: 64-77-7

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic -cells. The activity of various bio

Formula: C₁₂H₁₈N₂O₃S

Purezza: 98%

Colore e forma: White to pale cream, Powder or crystalline powder

Peso molecolare: 270.35

Ref: 02-B21698

Tolbutamide 1.0 mg/ml in Acetonitrile

CAS: 64-77-7

Colore e forma: Single Solution

Ref: 61-AMP1089.00-11

TOLBUTAMIDE CRS

CAS: 64-77-7

TOLBUTAMIDE CRS

Formula: C₁₂H₁₈N₂O₃S

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 270.3479

Ref: 41-T1700000

Tolbutamide

CAS: 64-77-7

Sulfonamides used as drugs

Formula: C₁₂H₁₈N₂O₃S

Colore e forma: White Crystalline Powder

Peso molecolare: 270.10381

Ref: 45-1670003

Tolbutamide

CAS: 64-77-7

Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.

Formula: C₁₂H₁₈N₂O₃S

Purezza: 99.80% - 99.93%

Colore e forma: White Crystalline Powder

Peso molecolare: 270.35

Ref: TM-T1054

Benzenesulfonamide, N-​[(butylamino)​carbonyl]​-​4-​methyl-

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 270.3479

Ref: IN-DA00E9I8

Tolbutamide

CAS: 64-77-7

Tolbutamide

Purezza: ≥98%

Peso molecolare: 270.35g/mol

Ref: 54-BUP18358

Tolbutamide

CAS: 64-77-7

Tolbutamide

Purezza: 99%

Peso molecolare: 270.35g/mol

Ref: 54-OR1028654

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Peso molecolare: 270.35

Ref: 7W-GP0797

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 270.35

Ref: 3B-T3690

Tolbutamide

Prodotto controllato

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Colore e forma: Neat

Peso molecolare: 270.35

Ref: 86-MM1089.00

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Colore e forma: Neat

Peso molecolare: 270.35

Ref: 04-C17589900

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Peso molecolare: 270.35

Ref: 4Z-T-048

Tolbutamide RS

CAS: 64-77-7

Colore e forma: White

Ref: 2K-1099000021

Tolbutamide

Prodotto controllato

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Colore e forma: Off-White

Peso molecolare: 270.35

Ref: TR-T535150

Tolbutamide

CAS: 64-77-7

Tolbutamide is a drug that is used to treat diabetes mellitus type 2. It is an inhibitor of the enzyme glucokinase and thus blocks the phosphorylation of glucose, which prevents its utilization by cells. This results in a decrease of blood glucose levels, which can be useful in the treatment of diabetes mellitus type 2. Tolbutamide has shown potent apoptosis-inducing effects on human breast cancer cells and endothelial cells. These effects are thought to be due to inhibition of protein kinase C (PKC) activity by tolbutamide. Additionally, this drug inhibits insulin secretion from pancreatic beta cells and induces cytochrome P450 enzymes, which may lead to increased metabolism of other drugs.

Formula: C₁₂H₁₈N₂O₃S

Purezza: Min. 95%

Peso molecolare: 270.35 g/mol

Ref: 3D-FT28304

Tolbutamide

CAS: 64-77-7

Formula: C₁₂H₁₈N₂O₃S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 270.35

Ref: 10-F047218

Tolbutamide

CAS: 64-77-7

Colore e forma: Neat

Ref: 61-FOR1089.00