CAS 649735-46-6

Brivanib

Descrizione:

Brivanib, con il numero CAS 649735-46-6, è una piccola molecola che funziona principalmente come inibitore duale delle vie di segnalazione del fattore di crescita endoteliale vascolare (VEGF) e del fattore di crescita dei fibroblasti (FGF). È classificata come un agente antitumorale, mirato specificamente a vari tumori solidi. Il composto presenta una struttura chimica complessa che gli consente di interferire con l'angiogenesi tumorale e la crescita inibendo le chinasi tirosina del recettore associate a queste vie. Brivanib è stato studiato in trial clinici per la sua efficacia nel trattamento di condizioni come il carcinoma epatocellulare e altre malignità. Le sue proprietà farmacocinetiche includono biodisponibilità orale e viene metabolizzato principalmente nel fegato. La sostanza ha mostrato una gamma di attività biologiche, inclusi effetti antiproliferativi sulle cellule tumorali. Tuttavia, come molte terapie mirate, può anche presentare effetti collaterali, il che richiede un attento monitoraggio durante il trattamento. In generale, Brivanib rappresenta un significativo progresso nello sviluppo di terapie mirate contro il cancro.

Formula: C₁₉H₁₉FN₄O₃

InChI: InChI=1/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1

InChI key: InChIKey=WCWUXEGQKLTGDX-LLVKDONJSA-N

SMILES: O(C=1C=2N(C=C(OC[C@@H](C)O)C2C)N=CN1)C=3C(F)=C4C(=CC3)NC(C)=C4

Sinonimi:

• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol
• (2R)-1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• 2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-, (2R)-
• Bms-540215
• Brivanib
• Ptk787
• Vatalanib
• (2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
• Bms540215
• Unii-ddu33B674i
• (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpy...
• (2R)-1-[4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol
• (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yloxy)propan-2-ol
• CS-75
• Brivanib(BMS-540215)
• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypr
• 1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-propan-2(R)-ol
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-yl]oxy]-2
• Brivanib, >=98%
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol USP/EP/BP
• (R)-1-(4-(4-fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol, BSM-540215
• (2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]ox
• (R)-1-(4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol
• Tyrosine Kinase Inhibitor

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol

CAS: 649735-46-6

Formula: C₁₉H₁₉FN₄O₃

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 370.3776

Ref: IN-DA00ECCZ

(R)-1-((4-((4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy)-5-Methylpyrrolo[2,1-f][1,2,4]Triazin-6-Yl)Oxy)Propan-2-Ol

CAS: 649735-46-6

(R)-1-((4-((4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy)-5-Methylpyrrolo[2,1-f][1,2,4]Triazin-6-Yl)Oxy)Propan-2-Ol

Purezza: 96%

Peso molecolare: 370.38g/mol

Ref: 54-PC108651

Brivanib

CAS: 649735-46-6

Brivanib

Purezza: ≥98%

Peso molecolare: 370.38g/mol

Ref: 54-BUP09111

Brivanib

CAS: 649735-46-6

Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against

Formula: C₁₉H₁₉FN₄O₃

Purezza: 98.87%

Colore e forma: Solid

Peso molecolare: 370.38

Ref: TM-T6036

BMS-540215

CAS: 649735-46-6

Ref: 7W-GW5097