CAS 65144-34-5

N-Metossisuccinil-Ala-Ala-Pro-Val-chetone clorometilico

Descrizione:

N-Metossisuccinil-Ala-Ala-Pro-Val-chetone clorometilico, con il numero CAS 65144-34-5, è un derivato peptidico sintetico che mostra specifiche proprietà biochimiche. Questo composto è caratterizzato dalla sua struttura, che include un gruppo metossisuccinile e una porzione di chetone clorometilico, contribuendo alla sua reattività e potenziali applicazioni nella ricerca biochimica. Viene spesso utilizzato come inibitore delle proteasi, in particolare negli studi che coinvolgono le proteasi seriniche, grazie alla sua capacità di formare legami covalenti con il sito attivo di questi enzimi. La presenza di residui di amminoacidi come alanina, prolina e valina nella sua sequenza suggerisce che possa imitare substrati naturali, consentendo un'inibizione selettiva. Inoltre, i gruppi metossilici e clorometilici migliorano la sua solubilità e stabilità in vari solventi, rendendolo adatto per l'uso in laboratorio. In generale, questo composto funge da strumento prezioso nello studio dei meccanismi enzimatici e nello sviluppo di agenti terapeutici mirati a vie proteolitiche.

Formula: C₂₂H₃₅ClN₄O₇

InChI: InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1

InChI key: InChIKey=PJGDFLJMBAYGGC-XLPNERPQSA-N

SMILES: C(N[C@H](C(CCl)=O)C(C)C)(=O)[C@H]1N(C([C@@H](NC([C@@H](NC(CCC(OC)=O)=O)C)=O)C)=O)CCC1

Sinonimi:

• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-[3-chloro-1-(1-methylethyl)-2-oxopropyl]-, (S)-
• Elastase inhibitor III
• MeOSuc-Ala-Ala-Pro-Val-chloromethylketone
• N-(4-Methoxy-1,4-dioxobutyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-<smallcap>L</span>-prolinamide
• N-(4-methoxy-4-oxobutanoyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-L-prolinamide
• N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[3-chloro-1-(1-methylethyl)-2-oxopropyl]-, (S)-
• L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-
• SPCK
• N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-(1-methylethyl)-2-oxopropyl]-L-prolinamide

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

CAS: 65144-34-5

Inhibitor of human neutrophil elastase. MeOSuc-AAPV-CMK was used for crystallizing hamster chymase 2.

Formula: C₂₂H₃₅ClN₄O₇

Purezza: 95.6%

Colore e forma: White Powder

Peso molecolare: 503.0

Ref: 01-4009927

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone elastase inhibitor

CAS: 65144-34-5

Formula: C₂₂H₃₅ClN₄O₇

Peso molecolare: 502.99

Ref: 7W-GL9803

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

CAS: 65144-34-5

MeOSuc-Ala-Ala-Pro-Val-chloromethylketone is a serine protease inhibitor that has been shown to be effective against influenza virus and HIV. It was found to be active against a number of serine proteases, such as trypsin, chymotrypsin, and elastase. MeOSuc-Ala-Ala-Pro-Val-chloromethylketone also has chemotactic activity in thp1 cells and lung fibroblasts. It is activated by the addition of water and has been shown to inhibit the growth of soybean trypsin. However, it does not have any effect on human trypsin.

Formula: C₂₂H₃₅ClN₄O₇

Purezza: Min. 95%

Peso molecolare: 502.99 g/mol

Ref: 3D-FM111010

MeOSuc-AAPV-CMK

CAS: 65144-34-5

MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated

Formula: C₂₂H₃₅ClN₄O₇

Colore e forma: Solid

Peso molecolare: 502.99

Ref: TM-T78633