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CAS 65147-06-0

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Boc-Ile-Glu-Gly-Arg-AMC

Descrizione:
Boc-Ile-Glu-Gly-Arg-AMC è un substrato peptidico sintetico comunemente utilizzato nella ricerca biochimica, in particolare negli studi che coinvolgono enzimi proteolitiche. Il nome indica che è un derivato degli amminoacidi isoleucina (Ile), acido glutammico (Glu), glicina (Gly) e arginina (Arg), con un gruppo protettivo Boc (tert-butilossicarbonile) sul residuo di isoleucina. Il gruppo AMC (7-amino-4-metilcumarina) funge da reporter fluorescente, consentendo il monitoraggio dell'attività enzimatica attraverso saggi di fluorescenza. Questo composto è tipicamente utilizzato in saggi per studiare le proteasi, poiché la scissione del legame peptidico da parte dell'enzima rilascia il gruppo AMC, risultando in un aumento della fluorescenza che può essere misurata quantitativamente. La stabilità del gruppo Boc in determinate condizioni lo rende adatto per vari allestimenti sperimentali. In generale, Boc-Ile-Glu-Gly-Arg-AMC è uno strumento prezioso nel campo dell'enzimologia e della chimica peptidica, contribuendo alla comprensione della cinetica enzimatica e della specificità del substrato.
Formula:C34H50N8O10
InChI:InChI=1/C34H50N8O10/c1-7-18(2)28(42-33(50)52-34(4,5)6)31(49)40-23(12-13-26(44)45)29(47)38-17-25(43)41-30(48)22(9-8-14-37-32(35)36)39-20-10-11-21-19(3)15-27(46)51-24(21)16-20/h10-11,15-16,18,22-23,28,39H,7-9,12-14,17H2,1-6H3,(H,38,47)(H,40,49)(H,42,50)(H,44,45)(H4,35,36,37)(H,41,43,48)/t18-,22-,23-,28-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=N[C@@H](CCC(=O)O)C(=NCC(=NC(=O)[C@H](CCCNC(=N)N)Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)N=C(O)OC(C)(C)C
Sinonimi:
  • tertiary-Butyloxycarbonyl-isoleucyl-glutamyl-glycyl-arginyl-7-amino-4-methylcoumarin
  • Biggam
  • Boc-ile-glu-gly-arg-mca
  • L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • N-(tert-butoxycarbonyl)-L-isoleucyl-L-alpha-glutamyl-N-{(2S)-5-[(diaminomethylidene)amino]-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanoyl}glycinamide
  • Boc-Ile-Glu-Gly-Arg-Amc Acetate Salt
Ordinare per
Purezza (%)
0
100
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0
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50
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90
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95
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100
4 prodotti.
  • Boc-Ile-Glu-Gly-Arg-AMC
    Bachem
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    Boc-IEGR-AMC, a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. The use of this substrate in the indirect determination of coagulation factor IX has been described.
    Formula:C34H50N8O10
    Purezza:97.8%
    Colore e forma:White Powder
    Peso molecolare:730.82

    Ref: 01-4004961

    25mg
    337,00€
    100mg
    982,00€
  • Boc-Ile-Glu-Gly-Arg-AMC
    Targetmol
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-IEGR-AMC: fluorogenic substrate for factor Xa and Halocynthia roretzi acrosin.</p>
    Formula:C34H50N8O10
    Purezza:98%
    Colore e forma:White Powder
    Peso molecolare:730.81

    Ref: TM-TP1129

  • Boc-Ile-Glu-Gly-Arg-AMC
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC is a cell permeable inhibitor of protein interactions that binds to the peptide sequences of the extracellular domain of the epidermal growth factor receptor (EGFR). Boc-Ile-Glu-Gly-Arg-AMC can be used as a research tool to study protein interactions, as well as an inhibitor for EGFR. It is soluble in DMSO and water. This product has been shown to inhibit the activity of ion channels such as voltage dependent calcium channels, potassium channels, and sodium channels. Boc-Ile-Glu-Gly-Arg-AMC also inhibits antibody binding to its antigen.</p>
    Formula:C34H50N8O10
    Purezza:Min. 95%
    Peso molecolare:730.81 g/mol

    Ref: 3D-MIE-3094-V

    5mg
    278,00€
  • Boc-Ile-Glu-Gly-Arg-AMC acetate salt
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC acetate salt

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC acetate salt is a homologous peptide derived from soybean trypsin inhibitor. It has a molecular weight of 7,000 daltons and inhibits the activity of serine proteases, including kallikrein, plasmin, and thrombin. This peptide has been shown to be an inhibitor of heparin coagulation factor Xa and tissue factor in vitro. Boc-Ile-Glu-Gly-Arg-AMC acetate salt also has anticoagulant properties in vivo which are due to its ability to inhibit the synthesis of prothrombin.</p>
    Formula:C34H50N8O10·C2H4O2
    Purezza:Min. 95%
    Colore e forma:Solid
    Peso molecolare:790.86 g/mol

    Ref: 3D-FB110485

    1g
    1.998,00€