CAS 65147-09-3

N-T-boc-leu-gly-arg 7-amido-4-*metilcumarina ace

Descrizione:

N-T-boc-leu-gly-arg 7-amido-4-metilcoumarina acetato, identificato dal suo numero CAS 65147-09-3, è un composto sintetico comunemente utilizzato nella ricerca biochimica, in particolare nello studio delle enzimi proteolitiche e nella sintesi di peptidi. Questo composto presenta un gruppo protettivo tert-butilossicarbonile (Boc), spesso impiegato per proteggere le funzionalità amminiche durante le reazioni chimiche. La presenza degli aminoacidi leucina (leu), glicina (gly) e arginina (arg) nella sua struttura indica che si tratta di un derivato peptidico, che può influenzare la sua attività biologica e le interazioni. La porzione 7-amido-4-metilcoumarina funge da etichetta fluorescente, rendendola utile per monitorare l'attività enzimatica o la scissione di peptidi in vari saggi. Il gruppo acetato migliora la solubilità e la stabilità nei sistemi biologici. In generale, questo composto è prezioso nello sviluppo di sonde basate su peptidi e nell'esplorazione della cinetica enzimatica, contribuendo ai progressi in campi come la scoperta di farmaci e la biologia molecolare.

Formula: C₂₉H₄₃N₇O₇

Sinonimi:

• Boc-Leu-Gly-Arg-AMC
• Boc-Leu-Gly-Arg-Amc Acetate Salt
• N(tert-BOC)-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate
• L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]-L-leucylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-T-boc-leu-gly-arg 7-amido-4-*methylcoumarin ace
• BOC-LEU-GLY-ARG-AMC ACOH
• BOC-LEU-GLY-ARG-MCA HYDROCHLORIDE
• N-T-BOC-LEU-GLY-ARG 7-AMIDO-4-METHYLCOUMARIN ACETATE)
• BOC-LGR-AMC
• N-ALPHA-T-BOC-L-LEU-GLY-L-ARG-4-METHYLCOUMARYL-7-AMIDE
• BOC-LEU-GLY-ARG-MCA
• Boc-Leu-Gly-Arg-7-amido-4-methylcoumarin acetate salt

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-LGR-AMC, a specific fluorogenic substrate for complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme. It is also hydrolyzed by macropain, a high molecular weight thiol proteinase from human erythrocytes. Stock solutions of Boc-LGR-AMC are best prepared in DMSO.

Formula: C₂₉H₄₃N₇O₇

Purezza: > 99%

Colore e forma: White Lyophilisate

Peso molecolare: 601.7

Ref: 01-4005550

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC

Purezza: ≥98%

Peso molecolare: 601.71g/mol

Ref: 54-BUP22193

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a fluorogenic substrate for detecting C3/C5 convertases, factor Xa, and soybean trypsin-like enzymes; it's also hydrolyzed by macropain.

Formula: C₂₉H₄₃N₇O₇

Purezza: 99.53%

Colore e forma: Solid

Peso molecolare: 601.69

Ref: TM-TP2169

Boc-Leu-Gly-Arg-AMC acetate salt

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC acetate salt is a potential drug target for leishmaniasis. It inhibits the growth of Leishmania by binding to the 17β-estradiol receptor and inhibiting protein synthesis. This drug also has a hydrolytic activity against proteins, which is activated by an acidic environment. It has been shown to inhibit the growth of bacteria including Staphylococcus aureus and Chlamydia pneumoniae by inhibiting urokinase-type plasminogen activator (uPA) and serine protease activities. Boc-Leu-Gly-Arg-AMC acetate salt has also been shown to inhibit cellular proliferation in cancer cells.

Formula: C₂₉H₄₃N₇O₇•C₂H₄O₂

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 661.74 g/mol

Ref: 3D-FB110486

Boc-Leu-Gly-Arg-AMC

CAS: 65147-09-3

Boc-Leu-Gly-Arg-AMC is a peptide that binds to the receptor for N-methyl-D-aspartate (NMDA) and inhibits the ion channel. It has been used as a research tool to study NMDA receptor interactions, as well as in cell biology and pharmacology. Boc-Leu-Gly-Arg-AMC is a high purity, ionic analog of glutamate that binds to the NMDA receptor without activating it, thereby inhibiting ion flow through the channel. This inhibition can be reversed by adding excess glutamate or glycine. The binding of this compound to the NMDA receptor has been shown to block activation of voltage gated calcium channels and reduce neuronal excitation, which may provide an alternative therapeutic strategy for controlling seizures or other neurological disorders.

Formula: C₂₉H₄₃N₇O₇

Purezza: Min. 95%

Peso molecolare: 601.69 g/mol

Ref: 3D-MLG-3102-V