CAS 65277-42-1

Ketoconazolo

Descrizione:

Ketoconazolo è un farmaco antifungino utilizzato principalmente per trattare varie infezioni fungine, comprese quelle che colpiscono la pelle e le mucose. Appartiene alla classe dei derivati dell'imidazolo e funziona inibendo la sintesi dell'ergosterolo, un componente critico delle membrane cellulari fungine, interrompendo così la loro integrità e funzione. Ketoconazolo è caratterizzato dalla sua relativamente bassa solubilità in acqua, ma è solubile in solventi organici, il che influisce sulla sua formulazione in forme di dosaggio topico e orale. La sostanza ha una formula molecolare che riflette la sua struttura complessa, che include più anelli e gruppi funzionali che contribuiscono alla sua attività farmacologica. Ketoconazolo è noto per le sue proprietà antifungine ad ampio spettro, rendendolo efficace contro una varietà di funghi, inclusi dermatofiti e lieviti. Tuttavia, il suo uso è stato associato a potenziali effetti collaterali, inclusa la epatotossicità e effetti endocrini, portando a restrizioni nel suo uso sistemico. Di conseguenza, viene spesso prescritto in formulazioni topiche per infezioni localizzate o in casi specifici in cui è giustificato il trattamento sistemico.

Formula: C₂₆H₂₈Cl₂N₄O₄

InChI: InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/s2

InChI key: InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5

Sinonimi:

• 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-[4-(4-{[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone
• 1-acetyl-4-(4-{[(2R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• Brizoral
• Cis-1-Acetyl-4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)Piperazine
• Ethanone, 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-, rel-
• Fungarest
• Fungoral
• Ketoconazol
• Ketoderm
• Ketoisdin
• Ketozoral
• Micosin
• Nizaral
• Nizoral
• Nizral
• Onofin K
• Orifungal M
• Panfungol
• Phytorol
• Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
• Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-
• R 41400
• Tocon
• cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
• rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone

Ketoconazole, 98%

CAS: 65277-42-1

Potent inhibitor of cytochrome P450c17

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: 98%

Colore e forma: White, Powder

Peso molecolare: 531.43

Ref: 02-J63367

Ketoconazole 2.0 mg/ml in Methanol

CAS: 65277-42-1

Colore e forma: Single Solution

Ref: 61-AMP0145.00-07

Ketoconazole impurity standard

CAS: 65277-42-1

Ketoconazole impurity standard

Colore e forma: Off-White

Ref: 47-1170

Ketoconazole

CAS: 65277-42-1

Ketoconazole

Formula: C₂₆H₂₈CI₂N₄O₄

Purezza: 100.0%

Colore e forma: White. To. Off-White

Peso molecolare: 726.02

Ref: 47-1169

KETOCONAZOLE RS

CAS: 65277-42-1

KETOCONAZOLE RS

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: Powder

Peso molecolare: 531.4309

Ref: 41-ICRS47046

KETOCONAZOLE CRS

CAS: 65277-42-1

KETOCONAZOLE CRS

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: Powder

Peso molecolare: 531.4309

Ref: 41-K0600000

Ketoconazole

CAS: 65277-42-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: White Off-White Powder

Peso molecolare: 530.14876

Ref: 45-1356508

1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 531.4309

Ref: IN-DA00352N

Ketoconazole

CAS: 65277-42-1

Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: 99.53% - 99.62%

Colore e forma: Crystals From 4-Methylpentanone Solid

Peso molecolare: 531.43

Ref: TM-T0679

Ketoconazole

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: ≥ 99.0% (anhydrous basis)

Colore e forma: White to off-white crystalline powder

Peso molecolare: 531.43

Ref: 7W-GA6740

Ketoconazole

CAS: 65277-42-1

Ketoconazole

Purezza: 98%

Peso molecolare: 531.43g/mol

Ref: 54-OR1030256

Ketoconazole

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 531.44

Ref: 4Z-K-018

Ketoconazole, EP grade

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: (Titration) 99.0 - 101.0 % (dried basis)

Colore e forma: White to almost white powder

Peso molecolare: 531.43

Ref: 7W-GA1761

Ketoconazole

CAS: 65277-42-1

Ketoconazole

Purezza: ≥98%

Peso molecolare: 531.43g/mol

Ref: 54-BUP17176

(±)-Ketoconazole-d4(piperazine-3,3,5,5-d4) (cis--isomers)

CAS: 1398065-75-2, 65277-42-1

Purezza: 98 atom % D

Colore e forma: White To Off-White Solid

Peso molecolare: 535.46

Ref: 3U-D7488

Ketoconazole

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 531.43

Ref: 3B-K0045

Ketoconazole

Prodotto controllato

CAS: 65277-42-1

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: Neat

Peso molecolare: 531.43

Ref: 04-C14532000

Ketoconazole

CAS: 65277-42-1

Colore e forma: Neat

Ref: 86-MM0145.00

Ketoconazole

Prodotto controllato

CAS: 65277-42-1

Applications Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Inhibitor of exosome secretion.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986); Scientific Reports 8: 8161 (2018)

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: Neat

Peso molecolare: 531.43

Ref: TR-K186000

Ketoconazole

CAS: 65277-42-1

Ketoconazole is an azole antifungal compound with a mode of action that inhibits ergosterol synthesis, disrupting fungal cell membranes. It is used for treating fungal infections of the skin and scalp.

Formula: C₂₆H₂₈Cl₂N₄O₄

Colore e forma: White Powder

Peso molecolare: 531.43 g/mol

Ref: 3D-FK24800