CAS 6543-77-7

4-Epidossiciclina

Descrizione:

4-Epidossiciclina è un derivato semisintetico dell'antibiotico tetraciclina, progettato specificamente per migliorare le sue proprietà antibatteriche. È caratterizzato dalla sua attività ad ampio spettro contro una varietà di batteri Gram-positivi e Gram-negativi, rendendolo efficace nel trattamento di varie infezioni. Il composto presenta una complessa struttura tetraciclica, essenziale per il suo meccanismo d'azione, che coinvolge principalmente l'inibizione della sintesi proteica batterica legandosi alla subunità 30S del ribosoma. 4-Epidossiciclina è noto per la sua stabilità in ambienti acidi, il che può migliorare la sua biodisponibilità. Inoltre, presenta un profilo di tossicità relativamente basso, rendendolo adatto per uso terapeutico. Tuttavia, come altre tetracicline, può causare effetti collaterali come disturbi gastrointestinali e fotosensibilità. Il suo uso è anche limitato dal potenziale sviluppo di resistenza agli antibiotici. In generale, 4-Epidossiciclina rappresenta un composto importante nel campo della terapia antimicrobica, contribuendo agli sforzi in corso per combattere le infezioni batteriche.

Formula: C₂₂H₂₄N₂O₈

InChI: InChI=1/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3/b21-13-/t7-,10+,14+,15+,17-,22-/m0/s1

InChI key: InChIKey=JBIWCJUYHHGXTC-NLJUDYQYSA-N

SMILES: O[C@]12[C@]([C@@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H]

Sinonimi:

• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, 4-epimer
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6R,12aS)-
• (4R,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• 4-Epioxytetracycline, 6-deoxy-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4R-(4α,4aβ,5β,5aβ,6β,12aβ)]-
• Doxycycline Impurity 3(Doxycycline EP Impurity C)(4-epi-Doxycycline)
• 4-EPI DOXYCYCLINE DXC03-100
• DOCYCYCLINE
• 4-Epi Doxycycline (>70%)
• Doxycycline hyclate EP Impurity C
• 4-Epi Doxycycline (Crude)
• 4-Epi Doxycycline Hydrochloride Q: What is the CAS Number of
• 4-Epi Doxycycline Hydrochloride
• 4-Epi Doxycycline Hydrochloride Q: What is the storage condition of
• 4-Epi Doxycycline Hydrochloride Q: What are the applications of
• (4S,5S,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a
• 4-Epi DoxycycL
• 6-Deoxy-4-epioxytetracycline USP/EP/BP
• 4-Epi Doxycycline
• Doxycycline Impurity 7
• Doxycycline Impurity 3（Doxycycline EP Impurity C）
• 4-Epi Doxycycline HydrochlorideQ: What is
• 6-Deoxy-4-epioxytetracycline
• Doxycycline EP Impurity C / 4-Epidoxycycline / Doxycycline Related Compound C
• Doxycycline EP Impurity C/4-Epi Doxycycline

Doxycycline EP Impurity C (4-epi Doxycycline)

CAS: 6543-77-7

Formula: C₂₂H₂₄N₂O₈

Peso molecolare: 444.44

Ref: 4Z-D-185

4-Epidoxycycline

CAS: 6543-77-7

4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.

Formula: C₂₂H₂₄N₂O₈

Colore e forma: Solid

Peso molecolare: 444.44

Ref: TM-T203210

Doxycycline EP Impurity C

CAS: 6543-77-7

Formula: C₂₂H₂₄N₂O₈

Peso molecolare: 444.44

Ref: ST-EA-CP-D56003

4-Epi Doxycycline (>70%)

Prodotto controllato

CAS: 6543-77-7

Impurity Doxycycline EP Impurity C
Stability Light Sensitive, Unstable in Solution
Applications An alternative to doxycycline to control gene expression.
References Schiffer, I., et al.: Cancer Res. 63, 7221 (2003) , Eger, K. , et al.: Biochem. Biophys. Res. Comm., 323, 979, (2004).

Formula: C₂₂H₂₄N₂O₈

Purezza: >70%

Colore e forma: Yellow Solid

Peso molecolare: 444.43

Ref: TR-E585900

4-Epidoxycycline

CAS: 6543-77-7

4-Epidoxycycline is a tetracycline antibiotic that inhibits the growth of bacteria by binding to bacterial ribosomes and blocking protein synthesis. This drug also has anti-inflammatory properties and can be used to treat bowel disease. 4-Epidoxycycline has been found to be effective in vivo models for experimental models of inflammatory lesions, such as ulcerative colitis, ileitis, or Crohn's disease. This antibiotic has not been shown to have any toxic effects on the heart or blood pressure.

Formula: C₂₂H₂₄N₂O₈

Purezza: 95%Min

Colore e forma: Powder

Peso molecolare: 444.43 g/mol

Ref: 3D-FE32560