CAS 656247-17-5

Nintedanib

Descrizione:

Nintedanib è un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento di alcuni tipi di cancro e malattie polmonari. È caratterizzato dalla sua capacità di inibire più tirosina chinasi recettoriali, comprese quelle coinvolte nell'angiogenesi, nella fibrosi e nella crescita tumorale. La formula chimica di Nintedanib è C27H29N5O3 e ha un peso molecolare di circa 463,55 g/mol. Nintedanib viene tipicamente somministrato per via orale ed è noto per la sua solubilità moderata ad alta nei solventi organici, mentre è meno solubile in acqua. Il composto presenta una struttura complessa con un nucleo biciclico, che contribuisce alla sua attività farmacologica. Il suo meccanismo d'azione implica il blocco delle vie di segnalazione che promuovono la proliferazione e la sopravvivenza cellulare, rendendolo efficace in condizioni come il cancro polmonare non a piccole cellule e la fibrosi polmonare idiopatica. Come molti farmaci, Nintedanib può avere effetti collaterali, tra cui disturbi gastrointestinali e aumenti degli enzimi epatici, richiedendo un attento monitoraggio durante il trattamento.

Formula: C₃₁H₃₃N₅O₄

InChI: InChI=1/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-

InChI key: InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N

SMILES: C(\NC1=CC=C(N(C(CN2CCN(C)CC2)=O)C)C=C1)(=C\3/C=4C(NC3=O)=CC(C(OC)=O)=CC4)/C5=CC=CC=C5

Sinonimi:

• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
• 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
• Bibf-1120
• Intedanib
• Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
• Vargatef
• methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
• Nintedanib
• 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone
• Nintedanib impurity 1
• methyl (Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
• methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
• 3-[(4-{Methyl-[2-(4-methyl-piperazin-1-yl)-acetyl]-amino}-phenylamino)-phenyl-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
• Nintedanib/Intedanib/Vargatef
• Nintedanib, Free Base, >99%
• methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate
• Vargatef (nintedanib)
• Nintedanib (BIBF 1120)
• BIBF-1120(Nintedanib,Vargatef)
• NTEDANIB
• (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-Indole-6-carboxylic acid methyl ester

Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

CAS: 656247-17-5

Purezza: 99+%

Colore e forma: Powder or crystals

Peso molecolare: 539.62

Ref: BD-BD161908

Nintedanib

CAS: 656247-17-5

Purezza: 97.0%

Colore e forma: Solid, No data available.

Peso molecolare: 539.635986328125

Ref: 10-F050741

(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

CAS: 656247-17-5

Formula: C₃₁H₃₃N₅O₄

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 539.6248

Ref: IN-DA00FBZI

Nintedanib-13C-d3

CAS: 656247-17-5

Formula: C₃₀₁₃CH₃₀D₃N₅O₄

Colore e forma: Yellow Solid

Peso molecolare: 543.65

Ref: 4Z-N-066020

Nintedanib

CAS: 656247-17-5

Nintedanib

Purezza: 99%

Peso molecolare: 539.62g/mol

Ref: 54-OR1029991

Nintedanib

CAS: 656247-17-5

Formula: C₃₁H₃₃N₅O₄

Colore e forma: Yellow Solid

Peso molecolare: 539.64

Ref: 4Z-N-066019

Nintedanib

CAS: 656247-17-5

Nintedanib

Purezza: ≥98%

Peso molecolare: 539.62g/mol

Ref: 54-BUP16962

Nintedanib

Prodotto controllato

CAS: 656247-17-5

Formula: C₃₁H₃₃N₅O₄

Colore e forma: Neat

Peso molecolare: 539.62

Ref: 86-MM3704.01

Nintedanib

CAS: 656247-17-5

Formula: C₃₁H₃₃N₅O₄

Purezza: >95.0%(T)(HPLC)

Colore e forma: White to Yellow to Yellow green powder to crystal

Peso molecolare: 539.64

Ref: 3B-N1313

Nintedanib

CAS: 656247-17-5

Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/

Formula: C₃₁H₃₃N₅O₄

Purezza: 98% - 99.92%

Colore e forma: Solid

Peso molecolare: 539.62

Ref: TM-T1777

Nintedanib (free base)

CAS: 656247-17-5

Formula: C₃₁H₃₃N₅O₄

Purezza: ≥ 99.0%

Colore e forma: White to yellow or beige solid

Peso molecolare: 539.62

Ref: 7W-GW5215

Intedanib

Prodotto controllato

CAS: 656247-17-5

Applications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Formula: C₃₁H₃₃N₅O₄

Colore e forma: Neat

Peso molecolare: 539.62

Ref: TR-I666650

Nintedanib

CAS: 656247-17-5

Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis . Nintedanib Bio-X is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1).

Formula: C₃₁H₃₃O₄N₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 539.63 g/mol

Ref: 3D-FM34144

Nintedanib - Bio-X ™

CAS: 656247-17-5

Nintedanib is an anti-inflammatory and anti-cancer drug. It is used for treatment of idiopathic pulmonary fibrosis. Nintedanib is a prodrug that is rapidly converted to the active form nintedanib, which inhibits angiogenesis by interfering with the activation of vascular endothelial growth factor receptor 1 (VEGFR1). 
Nintedanib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₁H₃₃O₄N₅

Purezza: (%) Min. 95%

Colore e forma: Yellow To Green-Yellow Solid

Peso molecolare: 539.63 g/mol

Ref: 3D-BN164249