CAS 65710-07-8

Solfato di apramicina

Descrizione:

Solfato di apramicina è un antibiotico aminoglicosidico derivato dal batterio *Micromonospora purpurea*. È utilizzato principalmente in medicina veterinaria per il trattamento di infezioni batteriche nel bestiame e negli uccelli. Il composto mostra un'attività antibatterica ad ampio spettro, in particolare contro i batteri Gram-negativi, ed è efficace nel trattamento di infezioni causate da alcuni ceppi di *Escherichia coli* e *Salmonella*. L'apramicina funziona inibendo la sintesi proteica batterica, legandosi alla subunità ribosomiale 30S, il che interrompe il processo di traduzione. La forma solfato ne migliora la solubilità e stabilità in soluzioni acquose, rendendola adatta per iniezione o somministrazione orale. In termini di sicurezza, l'apramicina è generalmente ben tollerata negli animali, ma è necessario prestare attenzione per evitare potenziali nefrotossicità e ototossicità, effetti collaterali comuni associati agli aminoglicosidi. Il suo utilizzo negli animali da produzione alimentare è soggetto a regolamentazioni per prevenire residui di antibiotici nei prodotti a base di carne. In generale, Solfato di apramicina è uno strumento prezioso in medicina veterinaria, contribuendo alla gestione delle malattie infettive nel bestiame.

Formula: C₂₁H₄₁N₅O₁₁·xH₂O₄S

InChI: InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI key: InChIKey=WGLYHYWDYPSNPF-RQFIXDHTSA-N

SMILES: O[C@H]1[C@@]2([C@@](O[C@H](O[C@H]3O[C@H](CO)[C@@H](N)[C@H](O)[C@H]3O)[C@H]1NC)(C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O2)[H])[H].S(=O)(=O)(O)O

Sinonimi:

• (2R,3R,4S,5S,6S)-5-Amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (1:1) (non-preferred name)
• (2R,3R,4S,5S,6S)-5-amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (salt) (non-preferred name)
• (2R,3S,4R,4aR,6S,7R,8aS)-7-Amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl 4-amino-4-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (2S,3S,4R,5S,6R)-2-[[(2R,3R,4aR,6S,7R,8S,8aR)-3-amino-2-[(1S,2S,3R,4R,6R)-4,6-diamino-2,3-dihydroxy-cyclohexoxy]-8-hydroxy-7-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-6-yl]oxy]-5-amino-6-(hydroxymethyl)tetrahydropyran-3,4-diol
• 265-890-7
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (salt)
• Ai3-29795
• Apramycin Sulfate
• Apramycin, sulfate (2:5)
• D-Streptamine, O-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)
• Sulfuric Acid
• Unii-8Uyl6Naz3Q
• D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (salt)

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate, 65710-07-8, is the salt of apramycin, a bacteriostatic aminoglycoside antibiotic with activity against gram-negative bacteria. Learn more.

Formula: C₂₁H₄₃N₅O₁₅S

Colore e forma: Pale yellow to yellow-brown powder, Powder

Peso molecolare: 637.66

Ref: 02-J66616

Apramycin sulfate, 96%

CAS: 65710-07-8

Potent inhibitor of protein synthesis in bacteria

Formula: C₂₁H₄₃N₅O₁₅S

Purezza: 96%

Colore e forma: Powder, Pale yellow to yellow

Peso molecolare: 637.66

Ref: 02-J63874

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.

Formula: C₂₁H₄₃N₅O₁₅S

Purezza: 99.14% - 99.96%

Colore e forma: Powder

Peso molecolare: 637.66

Ref: TM-T1084

Apramycin sulphate

CAS: 65710-07-8

Apramycin sulphate

Formula: C₂₁H₄₁N₅O₁₁·H₂SO₄

Colore e forma: light brown powder

Peso molecolare: 637.66g/mol

Ref: 54-BIA0164

Apramycin sulfate salt

CAS: 65710-07-8

Formula: C₂₁H₄₁N₅O₁₁·xH₂SO₄

Purezza: Apramycin: ≥ 550μg/mg (anhydrous basis)

Colore e forma: Yellow to dark yellow powder

Peso molecolare: 539.58 (free base)

Ref: 7W-GA8829

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate

Purezza: ≥98%

Peso molecolare: 637.66g/mol

Ref: 54-BUP18347

Apramycin Sulfate

CAS: 65710-07-8

Formula: C₂₁H₄₁N₅O₁₁·xH₂SO₄

Purezza: >90.0%(HPLC)

Colore e forma: Light yellow to Yellow powder to crystal

Ref: 3B-A3395

Apramycin sulfate

Prodotto controllato

CAS: 65710-07-8

Formula: C₂₁H₄₁N₅O₁₁·H₂O₄S

Colore e forma: Light Yellow

Peso molecolare: 637.66

Ref: 04-C10293000

Apramycin Sulfate

Prodotto controllato

CAS: 65710-07-8

Applications Broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.
References Thompson, R.Q., et al.: Antimicrob. Agents Chemother., 332 (1967), Ryden, R., et al.: J. Antimicrob. Chemother., 3, 609 (1977), Smith, P., et al.: Clin. Therap., 23, 1231 (2001),

Formula: C₂₁H₄₁N₅O₁₁·H₂O₄S

Colore e forma: Neat

Peso molecolare: 637.66

Ref: TR-A729600

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate is a semisynthetic antibiotic that inhibits the growth of Gram-negative bacteria. It is a sulfonamide and has been used in clinical isolates to treat bacterial infections. Apramycin sulfate inhibits the biosynthesis of folic acid, which is important for DNA synthesis and cell division. It also inhibits the production of RNA by binding to ribosomes and inhibiting protein synthesis. Apramycin has been shown to have anticancer properties as well, with studies showing that it can inhibit tumor growth in vitro and in vivo.

Formula: C₂₁H₄₁N₅O₁₁·H₂SO₄

Purezza: Min. 550 Usp U/Mg

Colore e forma: Brown Slightly Yellow Yellow Powder

Peso molecolare: 637.66 g/mol

Ref: 3D-AA15315

Apramycin Sulfate

CAS: 65710-07-8

Formula: C₂₁H₄₁N₅O₁₁H₂O₄S

Peso molecolare: 539.6 : 98.1

Ref: ST-EA-CP-A105002