CAS 66-76-2

Dicumarolo

Descrizione:

Dicumarolo è un composto chimico che appartiene alla classe degli anticoagulanti, specificamente un derivato della cumarina. È caratterizzato dalla sua capacità di inibire la vitamina K epossido reduttasi, che è cruciale per la sintesi di alcuni fattori di coagulazione nel fegato. Questa inibizione porta a una diminuzione dei livelli di vitamina K attiva, riducendo così la coagulazione del sangue. Dicumarolo appare come una polvere cristallina bianca a gialla pallida ed è scarsamente solubile in acqua, ma più solubile in solventi organici come etanolo e acetone. La sua formula molecolare è C18H12O5 e ha un peso molecolare relativamente basso. Il composto è utilizzato principalmente nella ricerca e ha un'importanza storica come uno dei primi anticoagulanti orali. A causa delle sue proprietà anticoagulanti, Dicumarolo deve essere usato con cautela, poiché può portare a complicazioni emorragiche se non monitorato correttamente. Inoltre, è stato studiato per i suoi potenziali effetti su vari processi biologici, incluso il suo ruolo nella ricerca sul cancro e come possibile agente terapeutico.

Formula: C₁₉H₁₂O₆

InChI: InChI=1/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2

InChI key: InChIKey=DOBMPNYZJYQDGZ-UHFFFAOYSA-N

SMILES: OC=1C=2C(OC(=O)C1CC3=C(O)C=4C(OC3=O)=CC=CC4)=CC=CC2

Sinonimi:

• 2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy-
• 3,3'-Methylenebis[4-hydroxy-1,2-benzopyrone]
• 3,3'-Methylenebis[4-hydroxycoumarin]
• 3,3′-Methylene-bis-(4-hydroxy-2H-benzopyran-2-one)
• 3,3′-Methylenebis(4-hydroxy-2H-chromen-2-one)
• 3,3′-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one]
• Acadyl
• Acavyl
• Antitrombosin
• Baracoumin
• Bis(4-hydroxycoumarin-3-yl)methane
• Bis-3,3'-(4-hydroxycoumarinyl)methane
• Bishydroxycoumarin
• Coumarin, 3,3'-methylenebis[4-hydroxy-
• Cuma
• Cumid
• Di-4-hydroxy-3,3'-methylenedicoumarin
• Dicoumal
• Dicoumarin
• Dicoumarol
• Dicuman
• Dicumarine
• Dicumol
• Dufalone
• Kumoran
• Melitoxin
• Nc 034
• Nsc 17860
• Nsc 221570
• Nsc 41834
• Pb 2-9
• Temparin
• Trombosan
• 3,3'-Methylen-bis(4-hydroxy-cumarin)
• syringidin
• dicoumarol 4,4'-dihydroxy-3,3'-methylenebis(2H-chromen-2-one)
• 3,3’-methylenebis(4-hydroxy-2h-1-benzopyran-2-on
• 3,3’-methylene-bis(4-hydroxycoumarine)
• 3,3μ-Methylenebis(4-hydroxycoumarin), Dicumarol
• DICUMAROL
• Dicumarol,99%
• 4,4’-dihydroxy-3,3’-methylenebiscoumarin
• 3,3’-metilen-bis(4-idrossi-cumarina)
• BIS-HYDROXYCOUMARIN
• 3,3’-methylenebis(4-hydroxy-coumari
• Dikumarol
• 3,3’-methylene-bis(4-hydroxycoumarine)(french)
• nc034
• 3,3'-Methylenebis
• 3,3'-Metilen-bis(4-idrossi-cumarina)
• Dicumarol (200 mg)
• Dicoumarin (=dicoumarol)
• METHYLENEBISHYDROXYCOUMARIN
• Dicumaol R
• Di-(4-hydroxy-3-coumarinyl)methane
• 3,3'-Methylene-bis(4-hydroxycoumarine)
• 3,3’-methyleen-bis(4-hydroxy-cumarine)
• 4-HYDROXY-3-[(4-HYDROXY-2-OXO-CHROMEN-3-YL)METHYL]CHROMEN-2-ONE
• dwukumarol
• BISCUMAROL
• 3,3’-methylen-bis(4-hydroxy-cumarin)
• dicumaolr
• 3,3'-Methyleen-bis(4-hydroxy-cumarine)
• 3,3’-methylenebis[4-hydroxy-2h-1-benzopyran-2-on

Dicoumarol

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 336.30

Ref: 3B-M0216

Dicumarol

CAS: 66-76-2

Vitamin K reductase inhibitor possessing anticoagulant properties

Formula: C₁₉H₁₂O₆

Colore e forma: Powder, White to off white

Peso molecolare: 336.30

Ref: 02-J63634

Dicumarol

CAS: 66-76-2

Colore e forma: Neat

Ref: 61-FOR3051.00

Dicoumarol

CAS: 66-76-2

Dicoumarol: an anticoagulant from moldy sweet-clover, depletes vitamin K, inhibits clotting enzymes.

Formula: C₁₉H₁₂O₆

Purezza: 99.75% - 99.9%

Colore e forma: White Or Creamy White Crystalline Powder Solid

Peso molecolare: 336.3

Ref: TM-T0809

Dicoumarol

CAS: 66-76-2

Dicoumarol

Purezza: ≥98%

Peso molecolare: 336.3g/mol

Ref: 54-BUP18867

3,3′-Methylene-bis(4-hydroxycoumarin)

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Peso molecolare: 336.30

Ref: 7W-GL3972

Dicoumarol

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purezza: 95%~99%

Peso molecolare: 336.299

Ref: BP-BP4979

Dicumarol

Prodotto controllato

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Colore e forma: Neat

Peso molecolare: 336.30

Ref: 04-C12581000

Dicumarol

Prodotto controllato

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Colore e forma: Neat

Peso molecolare: 336.30

Ref: 86-MM3051.00

Dicumarol-d8

Prodotto controllato

CAS: 66-76-2

Applications Isotope labelled Dicumarol is a natural chemical used as an anticoagulant agents that functions as a vitamin K antagonist and is also a derivative of coumarin (C755380).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sail, V., et al.: Chem. Biol. Drug. Design., 81, 334 (2013); Zsila, F., et al.: Molec. Pharma., 10, 1668 (2013); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012);

Formula: C₁₉D₈H₄O₆

Colore e forma: Light Yellow

Peso molecolare: 344.34

Ref: TR-D436592

Dicoumarol

CAS: 66-76-2

Dicumarol is a coumarin derivative that inhibits the activity of polymerase chain reaction (PCR) by binding to DNA. It is also an inhibitor of nitrate reductase, which is an enzyme that catalyzes the conversion of nitrate to nitrite. Dicumarol binds to the response element on DNA and blocks the transcription of genes. This drug also has been shown to inhibit squamous cell carcinoma cells through interaction with DNA and protein thiols.

Formula: C₁₉H₁₂O₆

Purezza: Min. 95%

Peso molecolare: 336.30 g/mol

Ref: 3D-FD28896

4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Purezza: 98.0%

Colore e forma: Solid

Peso molecolare: 336.299

Ref: 10-F358134

Dicumarol

Prodotto controllato

CAS: 66-76-2

Applications Dicumarol is a natural chemical used as an anticoagulant agents that functions as a vitamin K antagonist and is also a derivative of Coumarin (C755380).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sail, V., et al.: Chem. Biol. Drug. Design., 81, 334 (2013); Zsila, F., et al.: Molec. Pharma., 10, 1668 (2013); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012);

Formula: C₁₉H₁₂O₆

Colore e forma: Neat

Peso molecolare: 336.30

Ref: TR-D436590

3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one)

CAS: 66-76-2

Formula: C₁₉H₁₂O₆

Colore e forma: Solid

Peso molecolare: 336.2950

Ref: IN-DA003PE1