CAS 66085-59-4

Nimodipina

Descrizione:

Nimodipina è un bloccante dei canali del calcio diidropiridinico utilizzato principalmente in campo medico per la sua capacità di migliorare il flusso sanguigno cerebrale. È particolarmente indicato per la prevenzione di deficit neurologici ischemici dopo emorragia subaracnoidea. Il composto è caratterizzato dalla sua azione selettiva sui vasi sanguigni cerebrali, che porta a vasodilatazione senza influenzare significativamente la pressione arteriosa sistemica. Nimodipina ha una lipofilia relativamente alta, che facilita la sua penetrazione attraverso la barriera ematoencefalica. La sua struttura chimica include un anello di 1,4-diidropiridina, essenziale per la sua attività farmacologica. La sostanza viene tipicamente somministrata per via orale o endovenosa, e la sua farmacocinetica prevede un rapido assorbimento e metabolismo, con una emivita relativamente breve. Gli effetti collaterali comuni possono includere mal di testa, ipotensione e disturbi gastrointestinali. A causa della sua azione specifica e del profilo degli effetti collaterali, Nimodipina è un agente terapeutico prezioso in neurologia, particolarmente nella gestione di condizioni legate al vasospasmo cerebrale.

Formula: C₂₁H₂₆N₂O₇

InChI: InChI=1/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,17,19H,9-10H2,1-5H3/t17?,19-/m0/s1

InChI key: InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Sinonimi:

• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester
• 2-Methoxyethyl Propan-2-Yl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-O-(2-Methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Admon
• BAY-e 9736
• Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
• Nemotan
• Nimodipin
• Nimodipine AP
• Nimodipino
• Nimotop
• Periplum
• Nimodipine
• inedicarboxylate
• 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER
• isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid
• Bay e 9736, Admon, Nimotop, periplum
• NIMODIPINE EPN(CRM STANDARD)
• NIMODIPINE MM(CRM STANDARD)
• NIMODIPINE BP STANDARD(CRM STANDARD)
• 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid
• NIMODIPINE CALCIUM CHANNEL ANTAG
• ethoxyethyl1-methylethylester

Nimodipine, 98+%

CAS: 66085-59-4

Potent L-type calcium channel antagonist

Formula: C₂₁H₂₆N₂O₇

Purezza: 98+%

Colore e forma: Powder

Peso molecolare: 418.45

Ref: 02-J61287

Nimodipine

CAS: 66085-59-4

Colore e forma: Neat

Ref: 61-FOR0416.00

Nimodipine

CAS: 66085-59-4

Nimodipine

Formula: C₂₁H₂₆N₂O₇

Purezza: 100.0%

Colore e forma: Yellow Solid

Peso molecolare: 418.174

Ref: 47-651

NIMODIPINE CRS

CAS: 66085-59-4

NIMODIPINE CRS

Formula: C₂₁H₂₆N₂O₇

Peso molecolare: 418.4403

Ref: 41-N0850000

Nimodipine

CAS: 66085-59-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Yellow Crystalline Powder

Peso molecolare: 418.44

Ref: 45-1463858

Nimodipine

CAS: 66085-59-4

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

Formula: C₂₁H₂₆N₂O₇

Purezza: 99.64% - 99.79%

Colore e forma: Solid

Peso molecolare: 418.44

Ref: TM-T0343

Nimodipine

CAS: 66085-59-4

Nimodipine

Purezza: 98%

Peso molecolare: 418.44g/mol

Ref: 54-OR1030244

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Purezza: ≥ 98.0% (anhydrous basis)

Colore e forma: Off-white to yellow powder

Peso molecolare: 418.44

Ref: 7W-GP2955

Nimodipine

CAS: 66085-59-4

Nimodipine

Purezza: ≥98%

Peso molecolare: 418.44g/mol

Ref: 54-BUP14874

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Yellow Solid

Peso molecolare: 418.45

Ref: 4Z-N-151

Nimodipine

Prodotto controllato

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Neat

Peso molecolare: 418.44

Ref: 86-MM0416.00

Nimodipine 100 µg/mL in Acetonitrile

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Single Solution

Peso molecolare: 418.44

Ref: 04-A15526800AL-100

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Neat

Peso molecolare: 418.44

Ref: 04-C15526800

Nimodipine

CAS: 66085-59-4

Formula: C₂₁H₂₆N₂O₇

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 418.45

Ref: 3B-N0896

Nimodipine

CAS: 66085-59-4

Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.
References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Formula: C₂₁H₂₆N₂O₇

Colore e forma: Neat

Peso molecolare: 418.44

Ref: TR-N478200

Nimodipine

CAS: 66085-59-4

Nimodipine is a medication that belongs to the group of calcium channel blockers. It is used as a treatment for cerebral vasospasm, subarachnoid hemorrhage, and hypertensive emergencies. Nimodipine inhibits calcium influx into cells by blocking voltage-sensitive L-type calcium channels in smooth muscle cells. This medication has been shown to be effective when used with other drugs in the treatment of vasospasm or after aneurysm surgery. Nimodipine has also been shown to increase blood flow and improve brain function in patients with head injuries. The effects of nimodipine on cerebral blood flow have been demonstrated using whole-cell recordings from brain slices.

Formula: C₂₁H₂₆N₂O₇

Purezza: Min. 98 Area-%

Colore e forma: Slightly Yellow Powder

Peso molecolare: 418.44 g/mol

Ref: 3D-II57946

Nimodipine

CAS: 66085-59-4

M02160 - Nimodipine

Formula: C₂₁H₂₆N₂O₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 418.446

Ref: 10-M02160