CAS 66966-09-4

4-Metilumbelliferil α-L-iduronide

Descrizione:

4-Metilumbelliferil α-L-iduronide è un composto chimico sintetico utilizzato principalmente come substrato in saggi biochimici, in particolare per la rilevazione dell'attività dell'iduronidasi. È un derivato della 4-metilumbeliferone, che è un composto fluorescente, rendendolo utile in vari studi enzimatici. La presenza del gruppo α-L-iduronide consente che venga specificamente scisso dall'iduronidasi, rilasciando la fluorescente 4-metilumbeliferone, che può essere misurata quantitativamente. Questa proprietà è particolarmente preziosa nella diagnostica clinica per i disturbi da accumulo lisosomiale, come la mucopolisaccaridosi di tipo I. Il composto è tipicamente caratterizzato dalla sua solubilità in acqua e solventi organici, e mostra fluorescenza sotto luce UV, facilitando il suo utilizzo in ambienti di laboratorio. Le schede di sicurezza devono essere consultate per le linee guida di manipolazione e stoccaggio, come per qualsiasi sostanza chimica. In generale, 4-Metilumbelliferil α-L-iduronide serve come uno strumento importante in enzimologia e ricerca medica, aiutando nella comprensione delle vie metaboliche e dei meccanismi di malattia.

Formula: C₁₆H₁₆O₉

InChI: InChI=1S/C16H16O9/c1-6-4-10(17)24-9-5-7(2-3-8(6)9)23-16-13(20)11(18)12(19)14(25-16)15(21)22/h2-5,11-14,16,18-20H,1H3,(H,21,22)/t11-,12-,13+,14+,16+/m0/s1

InChI key: InChIKey=ARQXEQLMMNGFDU-ZHMBSYLPSA-N

SMILES: CC=1C=2C(=CC(O[C@@H]3O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1

Sinonimi:

• 4-Methyl-2-oxo-2H-1-benzopyran-7-yl alpha-L-ido-pyranosiduronic acid
• 4-Methyl-2-oxo-2H-1-benzopyran-7-yl α-<span class="text-smallcaps">L</span>-idopyranosiduronic acid
• 4-Methylumbelliferyl iduronide
• 4-Methylumbelliferyl α-<span class="text-smallcaps">L</span>-idopyranosiduronic acid
• 4-Methylumbelliferyl α-<span class="text-smallcaps">L</span>-iduronide
• 4-methyl-2-oxo-2H-chromen-7-yl alpha-L-idopyranosiduronic acid
• alpha-L-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl
• α-<span class="text-smallcaps">L</span>-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl
• 4-Methylumbelliferyl α-L-iduronide
• 4-Methyl-2-oxo-2H-1-benzopyran-7-yl α-L-idopyranosiduronic acid
• α-L-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl

4-Methylumbelliferyl-α-L-Iduronide

CAS: 66966-09-4

4-Methylumbelliferyl-α-L-Iduronide is a common substrate for α-L-iduronidase catalytic activity.

Formula: C₁₆H₁₆O₉

Colore e forma: Solid

Peso molecolare: 352.29

Ref: TM-T36370

Hymecromone-alfa-L-Iduronide

CAS: 66966-09-4

Formula: C₁₆H₁₆O₉

Peso molecolare: 352.29

Ref: 4Z-H-092003

4-Methylumbelliferyl α-L-iduronide (free acid)

CAS: 66966-09-4

4-Methylumbelliferyl α-L-iduronide (free acid)

Formula: C₁₆H₁₆O₉

Purezza: By hplc: >97% (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 352.29g/mol

Ref: 54-BIM2044

4-Methylumbelliferyl a-L-idopyranosiduronic acid

CAS: 66966-09-4

Formula: C₁₆H₁₆O₉

Purezza: ≥ 97.0%

Colore e forma: White to pale tan powder

Peso molecolare: 352.3

Ref: 7W-GC3812

4-Methylumbelliferyl α-L-Iduronide (free acid)

Prodotto controllato

CAS: 66966-09-4

Stability Hygroscopic
Applications 4-Methylumbelliferyl α-L-Iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase. This product form is the free acid, which offers a considerable weight for weight advantage over the 4-MU iduronide salt in terms of its application dose.
References Baxter, M.A., et al. 2002. Blood. 99: 1857-1859

Formula: C₁₆H₁₆O₉

Colore e forma: Neat

Peso molecolare: 352.29

Ref: TR-M337643

4-Methylumbelliferyl a-L-idopyranosiduronic acid

CAS: 66966-09-4

4-Methylumbelliferyl a-L-idopyranosiduronic acid is an ester that is used as a marker for the identification of glycolipids. It is a fluorogenic substrate for alpha-L-iduronidase used as a marker for the diagnosis of autoimmune diseases, including diabetic neuropathy. 4-Methylumbelliferyl a-L-idopyranosiduronic acid has been shown to inhibit inflammation and cancer, although it is not currently approved for this use. The mechanism by which 4-methylumbelliferyl a-L-idopyranosiduronic acid inhibits inflammation may be due to its ability to block cation channels on the surface of cells, thereby preventing inflammatory mediators from entering cells.

Formula: C₁₆H₁₆O₉

Purezza: Min. 97 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 352.29 g/mol

Ref: 3D-EM05276

4-Methylumbelliferyl-a-L-Iduronide Free Acid extrapure, 97%

CAS: 66966-09-4

Formula: C₁₆H₁₆O₉

Peso molecolare: 352.3

Ref: SR-86338

4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2,4-Disulfate Trisodium Salt

Prodotto controllato

CAS: 66966-09-4

Applications Intermediate in the production of fluorogenic substrates for enzyme assays.

Formula: C₁₆H₁₃Na₃O₁₅S₂

Colore e forma: Neat

Peso molecolare: 578.36

Ref: TR-M334710

Hymecromone-alfa-L-Iduronide

CAS: 66966-09-4

Formula: C₁₆H₁₆O₉

Peso molecolare: 352.30

Ref: ST-EA-CP-H32004