CAS 67-73-2

Fluocinolone 16,17-acetonide

Descrizione:

Fluocinolone 16,17-acetonide è un corticosteroide sintetico con proprietà anti-infiammatorie e immunosoppressive, utilizzato principalmente in applicazioni dermatologiche. È caratterizzato dalla sua potente attività glucocorticoide, che aiuta a ridurre l'infiammazione e alleviare i sintomi associati a varie condizioni della pelle, come eczema e psoriasi. Il composto ha una formula molecolare che riflette la sua struttura steroidea, con un nucleo di ciclopentanoperidrofenantrene, tipico dei corticosteroidi. Fluocinolone 16,17-acetonide viene tipicamente somministrato topicamente in formulazioni di unguento o crema, consentendo un trattamento localizzato con un'assorbimento sistemico minimo. La sua efficacia è attribuita alla sua capacità di inibire il rilascio di mediatori infiammatori e modulare le risposte immunitarie. Inoltre, il composto è noto per il suo rischio relativamente basso di effetti collaterali sistemici quando utilizzato correttamente. Tuttavia, l'uso prolungato può portare ad atrofia cutanea e ad altri effetti avversi locali. Come con tutti i corticosteroidi, è essenziale seguire le indicazioni mediche riguardo al suo utilizzo per massimizzare i benefici terapeutici riducendo al minimo i rischi potenziali.

Formula: C₂₄H₃₀F₂O₆

InChI: InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChI key: InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C([C@@H](F)C4)=CC(=O)C=C5)[H])[H]

Sinonimi:

• (4aS,4bR,5S,6aS,6bS,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (4aS,4bR,5S,6aS,6bS,9aR,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 16α,17α-Isopropylidene-6α,9α-difluoro-1,4-pregnadiene-11β,16α,17α,21-tetrol-3,20-dione
• 2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.
• 6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
• 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
• 6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
• 6alpha-Fluorotriamcinolone acetonide
• 6α, 9α-Difluoro-16α-hydroxypredonisolone-16, 17-acetonide
• 6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17 acetal with acetone
• 6α,9-Difluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
• 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
• 6α,9α-Difluoro-16α,17α-isopropylidenedioxy-Δ1-hydrocortisone
• 6α,9α-Difluoro-16α-hydroxyprednisolone 16,17-acetonide
• 6α-Fluorotriamcinolone acetonide
• Acetonida de fluocinolona
• Acetonida de fluocinolona [INN-Spanish]
• Acetonide de fluocinolone
• Acetonide de fluocinolone [INN-French]
• Acetonido De Fluocinolona
• Ccris 3250
• Coriphate
• Cortiplastol
• Derma-Smoothe/FS
• Dermalar
• Dermatin
• Dermatin (steroid)
• FS
• Flucinar
• Flucort
• Fluocet
• Fluocinolonacetonid
• Fluocinolonacetonidum
• Fluocinolone 16,17-acetonide
• Fluocinolone 16α,17α-acetonide
• Fluocinolone acetonide [DCIT]
• Fluocinolone acetonide [USAN:INN:JAN]
• Fluocinoloni acetonidum
• Fluocinoloni acetonidum [INN-Latin]
• Fluonid
• Fluotrex
• Fluovitef
• Fluovitif
• Flupollon
• Fluvean
• Fluzon
• Hsdb 3083
• Iluvien
• Jellin
• Localyn
• Localyn Syntex
• Neo-Synalar
• Nsc 92339
• Omniderm
• Percutina
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
• Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone (8CI)
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Prodermin
• Radiocin
• Retisert
• Rs 1401At
• Rs-1401 At
• Sinaflan
• Sinalar
• Synaflan
• Synalar
• Synalar-HP
• Synamol
• Synandone
• Synandrone
• Synemol
• Synotic
• Synsac
• Tefunote

Fluocinolone acetonide

CAS: 67-73-2

Corticosteroid; anti-inflammatory; treats dermatological conditions

Formula: C₂₄H₃₀F₂O₆

Purezza: Min. 97 Area-%

Colore e forma: Powder

Peso molecolare: 452.49 g/mol

Ref: 3D-FF15770

Fluocinolone acetonide - BP

CAS: 67-73-2

Fluocinolone acetonide is a fluorinated steroid acting as an inhibitor of nitric oxide synthase, thus preventing the production of nitric oxide and its effect on the vascular smooth muscles, resulting in reduced blood flow. Fluocinolone acetonide is a corticosteroid used in medicine for its anti-inflammatory, anti-pruritic and vasoconstrictive effects. Applied topically, it is prescribed by dermatologists to treat skin eczema, allergies, and psoriasis. In mice, fluocinolone acetonide has a proven tumour growth inhibiting activity.

Formula: C₂₄H₃₀F₂O₆

Purezza: Min. 95%

Peso molecolare: 452.49 g/mol

Ref: 3D-BF176452