CAS 67814-76-0

D-Streptamina, O-6-ammino-6-desossi-α-D-glucopiranosil-(1→4)-O-[3-desossi-4-C-metil-3-(metilammino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-ammino-2-idrossi-1-ossopropil]-2-desossi-, solfato (1:?)

Descrizione:

D-Streptamina, O-6-ammino-6-desossi-α-D-glucopiranosil-(1→4)-O-[3-desossi-4-C-metil-3-(metilammino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-ammino-2-idrossi-1-ossopropil]-2-desossi-, solfato (1:?) è un antibiotico aminoglicosidico glicosilato complesso. È caratterizzato dalla sua struttura intricata, che include più moieties di zucchero e un componente di amminoacido, contribuendo alla sua attività biologica. La presenza di gruppi solfato ne migliora la solubilità e la stabilità nei sistemi biologici. Questo composto presenta proprietà antibatteriche, mirando principalmente ai ribosomi batterici per inibire la sintesi proteica, rendendolo efficace contro una gamma di batteri Gram-negativi. Le sue caratteristiche strutturali uniche, comprese le specifiche legami glicosidici e i gruppi funzionali, sono cruciali per la sua interazione con i bersagli batterici. Inoltre, la stereochimica del composto gioca un ruolo significativo nel suo profilo farmacologico. Come molti aminoglicosidi, può avere effetti collaterali potenziali, inclusa la nefrotossicità e l'ototossicità, il che richiede una considerazione attenta nelle applicazioni terapeutiche. Nel complesso, la D-streptamina rappresenta una classe significativa di antibiotici con una rilevanza clinica importante.

Formula: C₂₂H₄₃N₅O₁₂·xH₂O₄S

InChI: InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1

InChI key: InChIKey=DDXRHRXGIWOVDQ-MGAUJLSLSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Sinonimi:

• (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Exacin
• Isepacin
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Isepamicin sulfate

Isepamicin Sulfate

CAS: 67814-76-0

Formula: C₂₂H₄₅N₅O₁₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 667.6816

Ref: IN-DA01DQ46

Isepamicin Sulfate

CAS: 67814-76-0

Isepamicin Sulfate

Purezza: 99%, ≥670μgmg

Peso molecolare: 667.68g/mol

Ref: 54-OR1025300

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate

Purezza: ≥98%

Peso molecolare: 667.68g/mol

Ref: 54-BUP06503

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate (sch21420), an aminoglycoside, targets 30S ribosomal unit, effective against type I 6-acetyltransferase strains.

Formula: C₂₂H₄₃N₅O₁₂·SH₂O₄

Purezza: 99.31% - 99.91%

Colore e forma: Solid

Peso molecolare: 667.68

Ref: TM-T6549

Isepamicin Sulfate

CAS: 67814-76-0

Formula: C₂₂H₄₃N₅O₁₂·H₂SO₄

Peso molecolare: 569.61 98.08

Ref: 4Z-I-157001

Isepamicin sulfate

CAS: 67814-76-0

Formula: C₂₂H₄₃N₅O₁₂

Purezza: ≥ 670μg/mg

Colore e forma: White to off-white powder

Peso molecolare: 569.60

Ref: 7W-GA5158

Isepamicin Sulfate

CAS: 67814-76-0

Stability Hygroscopic
Applications Isepamicin sulfate (CAS# 67814-76-0) is an aminoglycoside antibiotic with excellent capability of transference from venous blood to bone marrow blood.
References Li, G.; et al.: Zhongguo Xiandai Yixue Zazhi, 17, 1507 (2007).

Formula: C₂₂H₄₃N₅O₁₂•H₂O₄S

Colore e forma: Off-White

Peso molecolare: 569.609808

Ref: TR-I927013

Isepamicin sulphate

CAS: 67814-76-0

Isepamicin Sulphate is an aminoglycoside antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used for treating infections caused by gram-negative bacteria.

Formula: C₂₂H₄₃N₅O₁₂•H₂SO₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 667.68 g/mol

Ref: 3D-FI65046

Isepamicin sulfate - 70%

CAS: 67814-76-0

Isepamicin sulfate - 70% is a semi-synthetic aminoglycoside antibiotic, which is derived from naturally occurring antibiotic compounds through chemical modifications. Its mode of action involves binding to the bacterial 30S ribosomal subunit, disrupting protein synthesis and consequently causing bacterial cell death. This mechanism of action is typical of aminoglycosides, characterized by their bactericidal properties against a broad spectrum of Gram-negative bacteria, with some efficacy against certain Gram-positive bacterial strains.

Formula: C₂₂H₄₅N₅O₁₆S

Purezza: Min. 95%

Colore e forma: White/Off-White Solid

Peso molecolare: 667.68 g/mol

Ref: 3D-FI163230