CAS 67814-76-0
:D-Streptamina, O-6-ammino-6-desossi-α-D-glucopiranosil-(1→4)-O-[3-desossi-4-C-metil-3-(metilammino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-ammino-2-idrossi-1-ossopropil]-2-desossi-, solfato (1:?)
Descrizione:
D-Streptamina, O-6-ammino-6-desossi-α-D-glucopiranosil-(1→4)-O-[3-desossi-4-C-metil-3-(metilammino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-ammino-2-idrossi-1-ossopropil]-2-desossi-, solfato (1:?) è un antibiotico aminoglicosidico glicosilato complesso. È caratterizzato dalla sua struttura intricata, che include più moieties di zucchero e un componente di amminoacido, contribuendo alla sua attività biologica. La presenza di gruppi solfato ne migliora la solubilità e la stabilità nei sistemi biologici. Questo composto presenta proprietà antibatteriche, mirando principalmente ai ribosomi batterici per inibire la sintesi proteica, rendendolo efficace contro una gamma di batteri Gram-negativi. Le sue caratteristiche strutturali uniche, comprese le specifiche legami glicosidici e i gruppi funzionali, sono cruciali per la sua interazione con i bersagli batterici. Inoltre, la stereochimica del composto gioca un ruolo significativo nel suo profilo farmacologico. Come molti aminoglicosidi, può avere effetti collaterali potenziali, inclusa la nefrotossicità e l'ototossicità, il che richiede una considerazione attenta nelle applicazioni terapeutiche. Nel complesso, la D-streptamina rappresenta una classe significativa di antibiotici con una rilevanza clinica importante.
Formula:C22H43N5O12·xH2O4S
InChI:InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1
InChI key:InChIKey=DDXRHRXGIWOVDQ-MGAUJLSLSA-N
SMILES:O([C@H]1[C@H](NC([C@H](CN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O
Sinonimi:- (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N<sup>1</sup>-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N<sup>1</sup>-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N<sup>1</sup>-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
- Exacin
- Isepacin
- D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
- D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
- D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
- Isepamicin sulfate
Ordinare per
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9 prodotti.
Ref: IN-DA01DQ46
1mg56,00€5mg73,00€10mg88,00€25mg105,00€100mg119,00€50mg124,00€250mg141,00€1g169,00€5g562,00€Isepamicin sulfate
CAS:Isepamicin sulfate (sch21420), an aminoglycoside, targets 30S ribosomal unit, effective against type I 6-acetyltransferase strains.Formula:C22H43N5O12·SH2O4Purezza:99.31% - 99.91%Colore e forma:SolidPeso molecolare:667.68Ref: 4Z-I-157001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaIsepamicin sulfate
CAS:Formula:C22H43N5O12Purezza:≥ 670μg/mgColore e forma:White to off-white powderPeso molecolare:569.60Isepamicin sulphate
CAS:Isepamicin Sulphate is an aminoglycoside antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used for treating infections caused by gram-negative bacteria.Formula:C22H43N5O12•H2SO4Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:667.68 g/molIsepamicin Sulfate
CAS:Stability Hygroscopic
Applications Isepamicin sulfate (CAS# 67814-76-0) is an aminoglycoside antibiotic with excellent capability of transference from venous blood to bone marrow blood.
References Li, G.; et al.: Zhongguo Xiandai Yixue Zazhi, 17, 1507 (2007).Formula:C22H43N5O12•H2O4SColore e forma:Off-WhitePeso molecolare:569.609808Isepamicin sulfate - 70%
CAS:Isepamicin sulfate - 70% is a semi-synthetic aminoglycoside antibiotic, which is derived from naturally occurring antibiotic compounds through chemical modifications. Its mode of action involves binding to the bacterial 30S ribosomal subunit, disrupting protein synthesis and consequently causing bacterial cell death. This mechanism of action is typical of aminoglycosides, characterized by their bactericidal properties against a broad spectrum of Gram-negative bacteria, with some efficacy against certain Gram-positive bacterial strains.
Formula:C22H45N5O16SPurezza:Min. 95%Colore e forma:White/Off-White SolidPeso molecolare:667.68 g/mol
