CAS 67914-61-8

Deacetilchetoconazolo

Descrizione:

Deacetilchetoconazolo è un agente antifungino sintetico derivato dal ketoconazolo, utilizzato principalmente nel trattamento di varie infezioni fungine. Appartiene alla classe dei derivati imidazolici e presenta un'attività antifungina ad ampio spettro inibendo la sintesi dell'ergosterolo, un componente vitale delle membrane cellulari fungine. Questo composto è caratterizzato dalla sua capacità di interrompere la crescita e la riproduzione dei funghi, rendendolo efficace contro una gamma di dermatofiti e infezioni da lieviti. Deacetilchetoconazolo è tipicamente somministrato topicamente o per via orale, a seconda della condizione specifica da trattare. La sua farmacocinetica coinvolge assorbimento, distribuzione, metabolismo ed escrezione, che possono variare in base alla formulazione e alla via di somministrazione. Sebbene generalmente ben tollerato, gli effetti collaterali potenziali possono includere disturbi gastrointestinali e alterazioni degli enzimi epatici. Come con qualsiasi trattamento antifungino, può svilupparsi resistenza, richiedendo un attento monitoraggio e una potenziale terapia combinata. In generale, Deacetilchetoconazolo rappresenta un'opzione preziosa nell'arsenale antifungino, particolarmente per ceppi fungini resistenti.

Formula: C₂₄H₂₆Cl₂N₄O₃

InChI: InChI=1/C24H26Cl2N4O3/c25-18-1-6-22(23(26)13-18)24(16-29-10-7-28-17-29)32-15-21(33-24)14-31-20-4-2-19(3-5-20)30-11-8-27-9-12-30/h1-7,10,13,17,21,27H,8-9,11-12,14-16H2/t21-,24-/s2

InChI key: InChIKey=LOUXSEJZCPKWAX-DCJNBRHWNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCNCC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5

Sinonimi:

• 1-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
• Deacetylketoconazole
• Deacylketoconazole
• N-Deacetylketoconazole
• Piperazine, 1-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-
• Piperazine, 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel-
• R 39519
• rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
• cis-1-(4-((2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine

Ketoconazole Impurity D

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Purezza: 95%

Peso molecolare: 489.39

Ref: 3W-CS-P-00436

Ketoconazole EP Impurity D (Ketoconazole Metabolite (M14))

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 489.40

Ref: 4Z-K-016

Ketoconazole EP Impurity D

CAS: 67914-61-8

Ketoconazole EP Impurity D

Peso molecolare: 489.4g/mol

Ref: 54-BI12154

Deacylketoconazole

CAS: 67914-61-8

Deacylketoconazole

Purezza: ≥98%

Peso molecolare: 489.39g/mol

Ref: 54-BUP06572

Ketoconazole EP Impurity D

Prodotto controllato

CAS: 67914-61-8

Colore e forma: Neat

Ref: 86-MM0145.04

Ketoconazole Impurity 43

CAS: 67914-61-8

Formula: C₁₈H₁₆Cl₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 367.22

Ref: 4Z-K-0165

Deacetyl Ketoconazole

Prodotto controllato

CAS: 67914-61-8

Impurity Ketoconazole EP Impurity D
Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₂₄H₂₆Cl₂N₄O₃

Colore e forma: Off-White

Peso molecolare: 489.39

Ref: TR-D198955

Ketoconazole EP Impurity D

CAS: 67914-61-8

Formula: C₂₄H₂₆Cl₂N₄O₃

Peso molecolare: 489.40

Ref: ST-EA-CP-K2004

Deacetyl ketoconazole

CAS: 67914-61-8

Deacetyl ketoconazole is a synthetic molecule that inhibits the synthesis of cholesterol and triglycerides by blocking the production of acetyl-CoA. It also has an anti-inflammatory effect, inhibiting the release of corticotropin-releasing hormone and reducing uptake of triglycerides from the bloodstream. Deacetyl ketoconazole is used for the treatment of depression, insulin resistance, and dyslipidemia. The natural form of ketoconazole is racemic, containing equal amounts of enantiomers (R and S). Deacetyl ketoconazole consists only of the S enantiomer, which has been shown to be more potent than racemic ketoconazole in animal models. This drug is synthesized by reacting piperazine with 3-hydroxybenzaldehyde in a two step process involving oxidation followed by reduction.

Formula: C₂₄H₂₆Cl₂N₄O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 489.39 g/mol

Ref: 3D-FD20827

Deacylketoconazole

CAS: 67914-61-8

Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent.

Formula: C₂₄H₂₆Cl₂N₄O₃

Purezza: 98.35%

Colore e forma: Solid

Peso molecolare: 489.39

Ref: TM-T21022