CAS 6833-84-7

Nonactina

Descrizione:

Nonactina è un antibiotico polietere prodotto da alcune specie di batteri del genere Streptomyces. È caratterizzato dalla sua complessa struttura ciclica, che include più legami eterei che contribuiscono alle sue proprietà uniche. Nonactina mostra un alto grado di lipofilia, permettendogli di interagire efficacemente con le membrane biologiche. Questo composto è noto per la sua capacità di formare complessi con cationi, in particolare ioni di potassio, che interrompono l'omeostasi ionica cellulare e possono portare a effetti antimicrobici. Nonactina è stato studiato per le sue potenziali applicazioni in microbiologia e farmacologia, in particolare nel contesto della sua attività ionoforica. Inoltre, è stato utilizzato nella ricerca per indagare i meccanismi di trasporto delle membrane e la selettività ionica. La sua stabilità in varie condizioni e la sua tossicità relativamente bassa lo rendono un composto prezioso sia in laboratorio che in potenziali contesti terapeutici. Tuttavia, come molti antibiotici, il suo uso deve essere gestito con attenzione per prevenire lo sviluppo di resistenza nelle popolazioni microbiche.

Formula: C₄₀H₆₄O₁₂

InChI: InChI=1/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26-,27-,28?,29+,30-,31-,32+,33+,34-,35-,36+/m1/s1

InChI key: InChIKey=RMIXHJPMNBXMBU-QIIXEHPYSA-N

SMILES: C[C@@H]1[C@@]2(O[C@@](CC2)(C[C@H](C)OC(=O)[C@@H](C)[C@]3(O[C@](CC3)(C[C@@H](C)OC(=O)[C@H](C)[C@@]4(O[C@](C[C@H](C)OC(=O)[C@@H](C)[C@]5(O[C@@](C[C@@H](C)OC1=O)(CC5)[H])[H])(CC4)[H])[H])[H])[H])[H])[H]

Sinonimi:

• (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.1^7,10.1^16,19.1^25,28]tetracontane-3,12,21,30-tetrone
• (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.1~7,10~.1~16,19~.1~25,28~]tetracontane-3,12,21,30-tetrone
• 3584-A
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.1(sup 7,10).1(sup 16,19).1(sup 25,28))tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*))-
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.17,10.116,19.125,28)tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl- (8CI)
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.1^7,10.1^16,19.1^25,28]tetracontane, nonactin deriv.
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.1^7,10.1^16,19.1^25,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.1^7,10.1^16,19.1^25,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, [1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-
• 5342 Pfw 19
• A 4426
• A-5584
• Ammonium ionophore I
• Antibiotic from Actinomycete
• Brn 0076434
• E-79-C
• Fh-3582-A
• N-329-A
• Nsc 52141
• Nsc 56409
• Ta-25-M-I
• UPJOHN 170T, high melting
• Werramycin-A
• [1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.1^7,10.1^16,19.1^25,28]tetracontane-3,12,21,30-tetrone
• (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
• Nonactin
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane, nonactin deriv.
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, [1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*)]-
• 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
• 5-19-12-00751 (Beilstein Handbook Reference)
• NONACTIN FROM STREPTOMYCES TSUSIMAENSIS
• Ammonium ionophore, Nonactin
• NONACTIN FROM STREPTOMYCES GRISEUS
• 4,13,22,31,37,38,39,40-octaoxapentacyclo(32.2.1.1(sup7,10).1(sup16,19).1(sup
• AMMONIUM IONOPHORE
• NONACTIN, STREPTOMYCES GRISEUS
• nonactinfromstreptomycessp.
• NONACTINE, STREPTOMYCES GRISEUS
• Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade)
• POLYNACTIN
• Nonactin, Amonium Ionophore, Werramycin A, Polynactin
• NONACTINE, FROM STREPTOMYCES SP.
• 28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r
• Nonactin from Streptomyces griseus var griseus
• WerraMycin, FH 3582A, NSC 52141, AKD 1A, KD 1A
• NONACTIN USP/EP/BP
• 5342 Pfw 19 / A 4426 / Ammonium ionophore I

Nonactin

CAS: 6833-84-7

Formula: C₄₀H₆₄O₁₂

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 736.9290

Ref: IN-DA00FAE0

Nonactin

CAS: 6833-84-7

Formula: C₄₀H₆₄O₁₂

Purezza: ≥ 98.0%

Colore e forma: White or off-white powder

Peso molecolare: 736.9

Ref: 7W-GA6637

Nonactin from Streptomyces griseus

CAS: 6833-84-7

Nonactin from Streptomyces griseus

Formula: C₄₀H₆₄O₁₂

Purezza: By hplc: nonactin: 69.72%; monactin: (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 736.93g/mol

Ref: 54-BIN0110

Nonactin

CAS: 6833-84-7

Nonactin is a macrotetrolide antibiotic with action as an ionophore for potassium and ammonium ions and is used for research on ion transport and bacterial inhibition.

Formula: C₄₀H₆₄O₁₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 736.93 g/mol

Ref: 3D-AN32543