CAS 68767-14-6

Loxoprofene

Descrizione:

Loxoprofene è un farmaco antinfiammatorio non steroideo (FANS) utilizzato principalmente per le sue proprietà analgesiche e antinfiammatorie. È comunemente impiegato nel trattamento del dolore e dell'infiammazione associati a condizioni come artrite, dolore muscolare e disagio post-operatorio. Loxoprofene agisce inibendo le enzimi cicloossigenasi (COX), che svolgono un ruolo cruciale nella sintesi delle prostaglandine, composti che mediano l'infiammazione e il dolore. La sostanza è caratterizzata da un inizio d'azione relativamente rapido ed è spesso formulata in varie forme di dosaggio, comprese compresse e applicazioni topiche. Loxoprofene è noto per il suo profilo di sicurezza gastrointestinale favorevole rispetto ad altri FANS, rendendolo una scelta preferita in alcuni scenari clinici. Tuttavia, come tutti i farmaci, può avere effetti collaterali, tra cui disturbi gastrointestinali, rischi cardiovascolari e potenziali interazioni con altri farmaci. La sua struttura chimica include un derivato dell'acido propionico, contribuendo alla sua attività farmacologica. Come per qualsiasi farmaco, è essenziale utilizzare Loxoprofene sotto supervisione medica per garantire sicurezza ed efficacia.

Formula: C₁₅H₁₈O₃

InChI: InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)

InChI key: InChIKey=YMBXTVYHTMGZDW-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C(C(O)=O)C)C=C1)C2C(=O)CCC2

Sinonimi:

• 2-[4-(2-Oxo-Cyclopentylmethyl)-Phenyl]-Propionic Acid
• 2-[4-[(2-Oxocyclopentan-1-Yl)Methyl]Phenyl]Propionic Acid
• 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic acid
• 2-{4-[(2-Oxocyclopentyl)Methyl]Phenyl}Propanoic Acid
• A-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid
• Alpha-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid
• Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]-
• Ioxoprofen
• Koloxo
• Loxoprofen Acid
• ��-Methyl-4-[(2-Oxocyclopentyl)Methyl]Benzeneacetic Acid

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purezza: >97.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 246.31

Ref: 3B-L0244

Loxoprofen

CAS: 68767-14-6

Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.

Formula: C₁₅H₁₈O₃

Purezza: 98.59%

Colore e forma: White To Yellowish Crystalline Powder

Peso molecolare: 246.3

Ref: TM-T0463

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 246.3016

Ref: IN-DA003RD6

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purezza: ≥ 97.0%

Colore e forma: White to faint yellow crystalline powder

Peso molecolare: 246.30

Ref: 7W-GP1810

Loxoprofen

CAS: 68767-14-6

Loxoprofen

Purezza: ≥98%

Peso molecolare: 246.3g/mol

Ref: 54-BUP15038

Loxoprofen

CAS: 68767-14-6

Loxoprofen

Purezza: 98%

Peso molecolare: 246.3g/mol

Ref: 54-OR1030277

Loxoprofen

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Colore e forma: Off-White Solid

Peso molecolare: 246.31

Ref: 4Z-L-891

Loxoprofen Impurity 1 and Loxoprofen Impurity 50

CAS: 68767-14-6

Formula: C₁₈H₂₄O₅

Peso molecolare: 320.39

Ref: 4Z-L-8978

Loxoprofen-d4

CAS: 68767-14-6

Formula: C₁₅H₁₄D₄O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 250.33

Ref: 4Z-L-8921

Loxoprofen Sodium Salt Dihydrate

CAS: 226721-96-6, 68767-14-6, 80382-23-6

Formula: C₁₅H₁₇NaO₃·2H₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 304.32

Ref: 3B-L0252

Loxoprofen-d6

CAS: 68767-14-6

Formula: C₁₅H₁₂D₆O₃

Peso molecolare: 252.35

Ref: 4Z-L-897

Loxoprofen RS

CAS: 68767-14-6

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1188000021

Loxoprofen

Prodotto controllato

CAS: 68767-14-6

Applications Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);

Formula: C₁₅H₁₈O₃

Colore e forma: White To Off-White

Peso molecolare: 246.30

Ref: TR-L472905

Loxoprofen-d3

Prodotto controllato

CAS: 68767-14-6

Applications Loxoprofen-d3, is the labeled analogue of Loxoprofen (L472905), which is non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation.
References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);

Formula: C₁₅H₁₅D₃O₃

Colore e forma: Neat

Peso molecolare: 249.32

Ref: TR-L472907

Loxoprofen (low-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a non-steroidal anti-inflammatory drug that belongs to the class of drugs called pyrazoles. It is used in the treatment of inflammation and pain caused by arthritis, osteoarthritis, gout, menstrual pain, and dental pain. Loxoprofen binds to cyclooxygenase (COX) enzymes, thereby inhibiting prostaglandin synthesis. The COX enzymes are necessary for the production of prostaglandins that lead to inflammation and pain. Loxoprofen also inhibits bacterial translocation by binding to bacterial lipopolysaccharides on the cell surface and preventing their interaction with immune cells. Loxoprofen has been shown to inhibit colony stimulating factor (CSF) activity in vitro assays by disrupting CSF-1 binding to its receptor erythropoietin receptor or CD11b/CD18 integrin receptors on monocytes or neutrophils. This means that it will not stimulate the

Formula: C₁₅H₁₈O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 246.3 g/mol

Ref: 3D-FL172228

Loxoprofen (high-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a nonsteroidal anti-inflammatory drug that belongs to the group of drugs called NSAIDs. It has potent inhibitory activity against growth factor, which is important for the promotion of inflammation and tissue damage in diseases such as rheumatoid arthritis. Loxoprofen has been shown to have strong inhibitory effects on bacterial translocation in mice with colitis, which may be related to its ability to decrease the expression of endogenous substances through inhibition of colony-stimulating factor. Loxoprofen also has a high solubility in water (2g/L) and is soluble in biocompatible polymers such as polyvinylpyrrolidone.

Formula: C₁₅H₁₈O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 246.31 g/mol

Ref: 3D-FL172231

Loxoprofen (high-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a high-melting polymorph of loxoprofen, which is a nonsteroidal anti-inflammatory drug. Loxoprofen is used for the relief of pain and inflammation in patients with rheumatoid arthritis and osteoarthritis. It has been shown to be useful as an intermediate in the synthesis of other compounds, such as pharmaceuticals, pesticides, and dyes. Loxoprofen has also been found to be a useful building block in organic synthesis reactions that require high quality reagents.

Formula: C₁₅H₁₈O₃

Purezza: Min. 98.5 Area-%

Peso molecolare: 246.31 g/mol

Ref: 3D-Q-201324

2-(4-((2-Oxocyclopentyl)methyl)phenyl)propanoic acid

CAS: 68767-14-6

Formula: C₁₅H₁₈O₃

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 246.306

Ref: 10-F093438

Loxoprofen (low-melting polymorph)

CAS: 68767-14-6

Loxoprofen is a chemical intermediate that can be used to synthesize complex molecules. It has been shown to have many uses in the laboratory as a reaction component, reagent, or as a useful scaffold for research chemicals. Loxoprofen is also an effective building block for more complex compounds and can be used to synthesize speciality chemicals such as fine chemicals and pharmaceuticals. Loxoprofen is a white solid with low melting point that can be dissolved in organic solvents such as dichloromethane and chloroform.

Formula: C₁₅H₁₈O₃

Purezza: Min. 98.5 Area-%

Peso molecolare: 246.31 g/mol

Ref: 3D-Q-300011