CAS 693765-11-6

Flunarizine EP Impurity D DiHCl

CAS: 693765-11-6

Formula: C₂₆H₂₆F₂N₂·2HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 404.50 2*36.46

Ref: 4Z-F-084004

(Z)-Flunarizine

Prodotto controllato

CAS: 693765-11-6

Impurity Flunarizine EP Impurity D
Applications (Z)-Flunarizine is Z-isomer of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral). EP Impurity C
References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984),

Formula: C₂₆H₂₆F₂N₂

Colore e forma: Neat

Peso molecolare: 404.49

Ref: TR-F455205

(Z)-Flunarizine

CAS: 693765-11-6

Flunarizine is a drug that has been used to treat migraine and other headaches. It works by blocking the calcium ion channels which are responsible for transmitting pain signals from the nerves in the head to the brain. Flunarizine is a potent inhibitor of voltage-gated calcium channels, with an IC50 of 0.2 μM; it also blocks sodium and potassium ion channels at higher concentrations. The protein interactions of flunarizine have been studied using peptides and antibodies. Flunarizine also has been shown to inhibit phospholipase A2 and prostaglandin E2 synthase, leading to reduced inflammation, as well as being an antagonist at nicotinic acetylcholine receptors (nAChRs).

Formula: C₂₆H₂₆F₂N₂

Purezza: Min. 95%

Peso molecolare: 404.5 g/mol

Ref: 3D-TCB76511

Flunarizine EP Impurity D

CAS: 693765-11-6

Formula: C₂₆H₂₆F₂N₂

Peso molecolare: 404.5

Ref: ST-EA-CP-F140008