CAS 697235-38-4

(-)-Silvestrol

Descrizione:

(-)-Silvestrol è un composto naturale classificato come flavaglina, derivato dalla specie vegetale Aglaia silvestris. Presenta una struttura molecolare complessa caratterizzata da un sistema di anelli fusi che contribuisce alla sua attività biologica. Questo composto è noto per le sue potenti proprietà antitumorali, principalmente attraverso la sua capacità di inibire il fattore di inizio della traduzione eIF4A, interrompendo così la sintesi proteica nelle cellule tumorali. Inoltre, (-)-Silvestrol ha dimostrato attività anti-infiammatorie e antivirali, rendendolo un argomento di interesse nella ricerca farmacologica. La sua solubilità è tipicamente moderata e viene spesso studiato in vari sistemi di solventi per saggi biologici. La stereochimica del composto è cruciale per la sua attività, poiché la configurazione specifica influenza la sua interazione con i bersagli biologici. In generale, (-)-Silvestrol rappresenta un promettente composto guida nello sviluppo di nuovi agenti terapeutici, in particolare nel trattamento dell'oncologia e delle malattie infettive.

Formula: C₃₄H₃₈O₁₃

InChI: InChI=1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1

InChI key: InChIKey=GVKXFVCXBFGBCD-QKDMMWSPSA-N

SMILES: O[C@]12[C@]([C@@H]([C@@H](C(OC)=O)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)C=C(O[C@H]5[C@H](OC)OC[C@]([C@@H](CO)O)(O5)[H])C4)C6=CC=C(OC)C=C6

Sinonimi:

• (-)-Silvestrol
• Silvestrol
• 1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-
• (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester
• 1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-Methoxy-1,4-dioxan-2-yl]o xy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-Methoxy-3a-(4-Methoxypheny l)-3-phenyl-, Methyl ester, (1R,2R,3S,3aR,8bS)-

(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester

CAS: 697235-38-4

Formula: C₃₄H₃₈O₁₃

Purezza: 98.11%

Colore e forma: Solid

Peso molecolare: 654.6577

Ref: IN-DA00FC11

Silvestrol

CAS: 697235-38-4

Silvestrol

Peso molecolare: 654.661g/mol

Ref: 54-BI12132

Silvestrol

CAS: 697235-38-4

Silvestrol is a natural product with broad-spectrum antiviral. Furthermore, Silvestrol is an anti-cancer compound that is a potent and selective inhibitor of cyclin-dependent kinases, for example, eIF4A. It inhibits the proliferation of cancer cells by blocking their energy metabolism, inhibiting the production of ATP and glutathione (GSH). Silvestrol has been shown to have minimal toxicity in animal studies and can be used as an antitumor agent. It inhibits the Mcl-1 protein, which is a regulator of apoptosis, leading to tumor cell death. Silvestrol also has been shown to induce cell cycle arrest at G2/M phase in human tumor cells without affecting normal cells. The cyclin D2 gene, which is overexpressed in many cancers, may be a target for silvestrol treatment.

Formula: C₃₄H₃₈O₁₃

Purezza: Min. 95%

Peso molecolare: 654.66 g/mol

Ref: 3D-FS175699

Silvestrol

CAS: 697235-38-4

Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis.

Formula: C₃₄H₃₈O₁₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 654.66

Ref: TM-T16884