CAS 70209-81-3

Ivermectina B1b

Descrizione:

Ivermectina B1b è un composto di lattone macrociclica che fa parte della famiglia delle avermectine, noto principalmente per le sue proprietà antiparassitarie. È derivato dalla fermentazione del batterio del suolo Streptomyces avermitilis. Questo composto mostra un ampio spettro di attività contro vari parassiti, inclusi nematodi e artropodi, rendendolo ampiamente utilizzato in medicina veterinaria e in alcune applicazioni umane. Ivermectina B1b funziona legandosi ai canali del cloruro attivati dal glutammato, portando a un aumento della permeabilità della membrana cellulare agli ioni di cloruro, causando infine paralisi e morte dei parassiti. La sostanza viene tipicamente somministrata per via orale o topica, a seconda dell'organismo bersaglio. Ivermectina B1b è caratterizzato dalla sua tossicità relativamente bassa nei mammiferi, il che contribuisce al suo profilo di sicurezza quando usato correttamente. Tuttavia, è essenziale attenersi alle dosi raccomandate, poiché un sovradosaggio può portare a effetti avversi. La sua efficacia e sicurezza lo hanno reso un componente critico nel controllo delle infezioni parassitarie sia nel bestiame che negli esseri umani.

Formula: C₄₇H₇₂O₁₄

InChI: InChI=1S/C47H72O14/c1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b12-11+,26-14+,31-13+/t25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m0/s1

InChI key: InChIKey=VARHUCVRRNANBD-PVVXTEPVSA-N

SMILES: [C@H](C)(C)[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C\6/[C@@]7(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]7(OC6)[H])[H])[H])[H])CC[C@@H]1C

Sinonimi:

• (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-(1-methylethyl)-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-ribo-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside
• (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-Tetradecahydro-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyran
• (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-Tetradecahydro-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
• 22,23-Dihydroavermectin B_1b
• 5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A_1a
• Avermectin A(sub 1a), 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
• Avermectin A_1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
• Avermectin H2B1b
• Ivermectin B1b
• Ivermectin B_1b
• Ivermectin component B(sub 1b)
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-0W28Cyi3Tu
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv.
• 22,23-Dihydroavermectin B1b
• Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-

Ivermectin B1b

CAS: 70209-81-3

Ivermectin B1b, minor antiparasitic, binds to nematode glutamate channels, causing lasting hyperpolarization and paralysis.

Formula: C₄₇H₇₂O₁₄

Colore e forma: Solid

Peso molecolare: 861.079

Ref: TM-T37748

Ivermectin B1b

CAS: 70209-81-3

Formula: C₄₇H₇₂O₁₄

Peso molecolare: 861.08

Ref: 4Z-I-077019

Ivermectine B1b

CAS: 70209-81-3

Colore e forma: Off White

Ref: 04-CA14488007

Ivermectin B1b

Prodotto controllato

CAS: 70209-81-3

Formula: C₄₇H₇₂O₁₄

Colore e forma: Off White

Peso molecolare: 861.066

Ref: TR-I940825

Ivermectin B1b

CAS: 70209-81-3

Formula: C₄₇H₇₂O₁₄

Peso molecolare: 861.08

Ref: ST-EA-CP-I18018

22,23-Dihydroavermectin B1b (Ivermectin B1b)

CAS: 70209-81-3

Ivermectin is a drug that belongs to the anthelmintic class of drugs. It is active against roundworms, pinworms, and hookworms. Ivermectin has been shown to have an effect on autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis by inhibiting the inflammatory response. The drug has been shown to inhibit matrix metalloproteinases in vitro and in vivo. The matrix effect is seen when the drug binds to proteins in the blood plasma or tissue matrix, where it inhibits their activity. This inhibition prevents the degradation of collagen, which can lead to tissue damage or renal failure. Ivermectin also binds to striatal dopamine receptors and inhibits dry weight gain in animals infected with Ostertagia ostertagi. Ivermectin is given orally in a single dose of 200 micrograms/kg body weight for treatment of intestinal worms (roundworm,

Formula: C₄₇H₇₂O₁₄

Purezza: Min. 95%

Peso molecolare: 861.07 g/mol

Ref: 3D-FD177819