CAS 7059-24-7

Cromomicina A3

Descrizione:

Cromomicina A3 è un antibiotico antraciclino prodotto dal batterio *Streptomyces griseus*. È principalmente conosciuto per il suo utilizzo nel trattamento del cancro grazie alla sua capacità di intercalare il DNA, inibendo così la sintesi di DNA e RNA. Questo composto presenta un colore giallo brillante ed è solubile in acqua, il che facilita il suo utilizzo in varie applicazioni biologiche. Cromomicina A3 ha una formula molecolare che riflette la sua struttura complessa, caratterizzata da più anelli aromatici e moieties di zucchero, che contribuiscono alla sua attività biologica. Il suo meccanismo d'azione implica il legame a regioni ricche di GC del DNA, portando all'interruzione dei processi cellulari nelle cellule in rapida divisione, caratteristica di molti agenti anticancro. Inoltre, Cromomicina A3 è stato studiato per il suo potenziale utilizzo in biologia molecolare come sonda fluorescente per la rilevazione del DNA. Tuttavia, il suo utilizzo clinico è limitato a causa della potenziale tossicità e degli effetti collaterali, richiedendo una considerazione attenta nelle applicazioni terapeutiche. In generale, Cromomicina A3 rappresenta un composto significativo nel campo della chimica medicinale e della ricerca sul cancro.

Formula: C₅₇H₈₂O₂₆

InChI: InChI=1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1

InChI key: InChIKey=ZYVSOIYQKUDENJ-WKSBCEQHSA-N

SMILES: O=C1C=2C(C[C@@]([C@@H](C([C@H]([C@@H](C)O)O)=O)OC)([C@@H]1O[C@H]3C[C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O5)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)[H])=CC=6C(C2O)=C(O)C(C)=C(O[C@H]7C[C@@H](O[C@@H]8C[C@@H](O)[C@@H](OC)[C@@H](C)O8)[C@@H](OC(C)=O)[C@@H](C)O7)C6

Sinonimi:

• (1S)-1-C-[(2S,3S)-7-[[4-O-Acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-<span class="text-smallcaps">D</smallcap>-lyxo-hexopyranosyl)-β-<smallcap>D</smallcap>-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-<smallcap>D</span>-threo-2-pentulose
• (1S)-1-C-[(2S,3S)-7-{[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-alpha-D-lyxo-hexopyranosyl)-beta-D-lyxo-hexopyranosyl]oxy}-3-{[4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-5-deoxy-1-O-methyl-D-xylulose
• 3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D
• <span class="text-smallcaps">D</smallcap>-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-<smallcap>D</smallcap>-lyxo-hexopyranosyl)-β-<smallcap>D</smallcap>-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<smallcap>L</smallcap>-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-<smallcap>D</span>-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-, (1S)-
• Aburamycin B
• Antibiotic 69895 A
• Antibiotic B 599
• Antibiotic from Streptomyces griseus
• CMA³
• Ccris 2755
• Chromomycin A(sub 3)
• Chromomycin A₃
• Nsc 58514
• Olivomycin D, 3^D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)-7-methyl-
• Olivomycin D, 3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methyl- (9CI)
• Olivomycin D, 3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabinohexopyranosyl)-7-methyl-
• Olivomycin D, 3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methyl-
• Toyomycin
• (1S)-1-C-[(2S,3S)-7-[[4-O-Acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-D-threo-2-pentulose
• D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-, (1S)-
• Chromomycin A3

Chromomycin A3, 97%

CAS: 7059-24-7

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate G-C box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting tr

Formula: C₅₇H₈₂O₂₆

Purezza: 97%

Colore e forma: Yellow, Powder or crystals or crystalline powder

Peso molecolare: 1183.26

Ref: 02-J62927

Chromomycin A3

CAS: 7059-24-7

Formula: C₅₇H₈₂O₂₆

Purezza: ≥ 98%

Colore e forma: Yellow powder

Peso molecolare: 1183.30

Ref: 7W-GA6463

Chromomycin A3

CAS: 7059-24-7

Chromomycin A3 is an antibioti,inhibits DNA replication and transcription; a fluorescent DNA stain and assay; anticancer Hodgkin's,melanomas, and breast cancer.

Formula: C₅₇H₈₂O₂₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1183.24

Ref: TM-T10810

Chromomycin A3

CAS: 7059-24-7

Chromomycin A3

Formula: C₅₇H₈₂O₂₆

Purezza: By hplc: 99.39% (Typical Value in Batch COA)

Colore e forma: yellow powder

Peso molecolare: 1,183.25g/mol

Ref: 54-BIC1009

Chromomycin A3 from streptomyces griseus

CAS: 7059-24-7

Chromomycin A3 (CMA3) is a cytotoxic antibiotic that is produced by Streptomyces griseus. CMA3 inhibits DNA synthesis and provides protection against bacterial infection, as well as cancer cells. It binds to the D-loop region of duplex DNA, which prevents the progression of polymerase chain reactions. CMA3 has been shown to be effective in inhibiting growth of gram-positive bacteria and gram-negative bacteria, as well as many species of fungi. The use of CMA3 may be complicated by its toxicity to animal cells, so it should only be used in combination with other antibiotics because it can reduce the toxicity of other drugs.

Formula: C₅₇H₈₂O₂₆

Purezza: Min. 95 Area-%

Colore e forma: Powder

Peso molecolare: 1,183.25 g/mol

Ref: 3D-FC41668