CAS 7075-11-8

citosina B-D-arabinofuranoside*5'-monofosfato F

Descrizione:

La citosina B-D-arabinofuranoside 5'-monofosfato F, comunemente nota con il suo numero CAS 7075-11-8, è un analogo di nucleoside che gioca un ruolo significativo nella biologia molecolare e nella farmacologia. Questo composto è un derivato della citosina, una delle quattro principali nucleobasi nel DNA e nell'RNA, e presenta un gruppo zuccherino arabinofuranosilico. La sua struttura include un gruppo fosfato attaccato alla posizione 5', che è cruciale per la sua funzione nella sintesi e nel metabolismo degli acidi nucleici. La citosina B-D-arabinofuranoside 5'-monofosfato F è nota per le sue potenziali proprietà antivirali e anticancro, poiché può interferire con la sintesi degli acidi nucleici nelle cellule in rapida divisione. Il composto è tipicamente utilizzato in contesti di ricerca per studiare i processi cellulari e i meccanismi d'azione di vari agenti terapeutici. La sua solubilità e stabilità nei sistemi biologici lo rendono uno strumento prezioso nello sviluppo di farmaci basati su nucleosidi. In generale, questo composto esemplifica l'intersezione tra chimica e biologia nella ricerca di strategie terapeutiche efficaci.

Formula: C₉H₁₄N₃O₈P

InChI: InChI=1/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7+,8-/m1/s1

Sinonimi:

• Ara-5'-CMP
• 1-beta-D-Arabinofuranosylcytosine 5'-monophosphate
• 1-beta-D-Arabinofuranosylcytosine 5'-phosphate
• 1beta-Arabino-furanosylcytosine-5'-monophosphoric acid, D-
• Arabinosylcytosine 5'-monophosphate
• Aracytidine 5'-monophosphate
• Aracytidine 5'-phosphate
• Cytarabine 5'-monophosphate
• Cytosine arabinoside 5'-monophosphate
• Cytosine arabinoside 5'-phosphate
• Cytosine arabinoside 5'MP
• Cytosine arabinoside monophosphate
• Nsc 99445
• 2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphono-beta-D-arabinofuranosyl)-
• Cytosine, 1-beta-D-arabinofuranosyl-, 5'-(dihydrogen phosphate) (8CI)
• 4-amino-1-(5-O-phosphono-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
• 1-β-D-Arabinofuranosylcytosine 5'-monophosphate
• 4-AMino-1-(5-O-phosphono-β-D-arabinofuranosyl)-
• CYTOSINE BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE
• cytosine B-D-arabinofuranoside*5'-monophosphate F
• ARA-CMP
• 4-Amino-1-(5-O-phosphono-β-D-arabinofuranosyl)-1,2-dihydropyrimidin-2-one
• [(2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• ((2R,3S,4S,5R)-5-(4-AMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate
• cytosine β-d-arabinofuranoside 5'-monophosphate
• 4-Amino-1-[5-O-(dihydroxyphosphinyl)-β-D-arabinofuranosyl]pyrimidine-2(1H)-one
• 1-beta-d-arabinofuranosylcytosine5’-monophosphate
• ((2R,3S,4S,5R)
• CYTOSINE B-D-ARABINOFURANOSIDE5'-MONOPHO SPHATE FRE
• Cytarabine Monophosphate
• 4-Amino-1-(5-O-phosphono--D-arabinofuranosyl)-2(1H)-pyrimidinone
• Cytarabine Impurity 8
• 1--D-Arabinofuranosylcytosine 5'-Monophosphate
• Cytarabine 5a€-Monophosphate
• 5'-Monophosphate cytosine arabiniside
• 1-(2-Oxo-1,2-dihydro-4-aminopyrimidine-1-yl)-1-deoxy-β-D-arabinofuranose 5-phosphoric acid
• Cytosine--D-arabinofuranoside-5'-monophosphoric Acid
• 1-β-D-adenosineabinofuranosylcytosine-5'-monophosphate
• 2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphono-β-D-arabinofuranosyl)-
• 2(1H)-Pyrimidinone,4-amino-1-(5-O-phosphono-b-D-arabinofuranosyl)-
• Cytosine-beta-D-arabinofuranoside-5zzhlxy-monophosphate

2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphono-b-D-arabinofuranosyl)-

CAS: 7075-11-8

Formula: C₉H₁₄N₃O₈P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 323.1965

Ref: IN-DA00IC3K

Cytosine-β-D-arabinofuranoside-5''-monophosphate

CAS: 7075-11-8

Formula: C₉H₁₄N₃O₈P

Purezza: ≥ 99.0%

Colore e forma: White to off-white powder

Peso molecolare: 323.20

Ref: 7W-GE8537

Cytarabine Monophosphate

CAS: 7075-11-8

Formula: C₉H₁₄N₃O₈P

Peso molecolare: 323.20

Ref: 4Z-C-150003

Cytarabine-13C3 5’-Monophosphate

Prodotto controllato

CAS: 7075-11-8

Stability Hygroscopic
Applications A labelled derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.
References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),

Formula: C₆C₃H₁₄N₃O₈P

Colore e forma: Neat

Peso molecolare: 326.17

Ref: TR-C998107

Cytarabine 5’-Monophosphate

Prodotto controllato

CAS: 7075-11-8

Stability Hygroscopic, Unstable in Solution
Applications A derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.
References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),

Formula: C₉H₁₄N₃O₈P

Colore e forma: Neat

Peso molecolare: 323.20

Ref: TR-C998105

1-(β-D-Arabinofuranosyl)cytosine 5'-monophosphate

CAS: 7075-11-8

1-(β-D-Arabinofuranosyl)cytidine 5'-monophosphate (ara-CMP) is a nucleotide derivative of cytidine, specifically a nucleotide where the ribose sugar is replaced by the arabinose sugar. It's a pyrimidine nucleotide commonly known as Cytarabine 5'-monophosphate or arabinosylcytosine 5'-monophosphate.

Formula: C₉H₁₄N₃O₈P

Purezza: Min. 95 Area-%

Colore e forma: White Powder

Peso molecolare: 323.2 g/mol

Ref: 3D-NA10080

Cytarabine 5′-monophosphate

CAS: 7075-11-8

Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.

Formula: C₉H₁₄N₃O₈P

Colore e forma: Solid

Peso molecolare: 323.198

Ref: TM-T84932