CAS 71142-71-7

H-D-Fenil-Pro-Arg-clorometilchetone

Descrizione:

H-D-Fenil-Pro-Arg-clorometilchetone, noto anche con il suo numero CAS 71142-71-7, è un derivato peptidico sintetico che funge da potente inibitore di alcune enzimi proteolitiche, in particolare le serina proteasi. Questo composto presenta un gruppo funzionale clorometilchetone, che è cruciale per il suo meccanismo d'azione, permettendogli di formare legami covalenti con il sito attivo delle enzimi target, inibendo così la loro attività. La presenza degli aminoacidi fenilalanina (Phe), prolina (Pro) e arginina (Arg) nella sua struttura contribuisce alla sua specificità e affinità di legame. H-D-Fenil-Pro-Arg-clorometilchetone è spesso utilizzato nella ricerca biochimica per studiare la cinetica enzimatica e l'inibizione delle proteasi, rendendolo prezioso nello sviluppo di farmaci e nelle applicazioni terapeutiche. La sua stabilità e reattività sono influenzate dal pH e dalle condizioni di temperatura circostanti, che sono considerazioni importanti nei set sperimentali. Come per molti derivati peptidici, è essenziale maneggiare questo composto con cura, seguendo i protocolli di sicurezza a causa della sua potenziale attività biologica.

Formula: C₂₁H₃₁ClN₆O₃

InChI: InChI=1/C21H31ClN6O3/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26)/t15-,16+,17+/m1/s1

InChI key: InChIKey=KWPACVJPAFGBEQ-IKGGRYGDSA-N

SMILES: C(N[C@@H](CCCNC(=N)N)C(CCl)=O)(=O)[C@H]1N(C([C@@H](CC2=CC=CC=C2)N)=O)CCC1

Sinonimi:

• 13: PN: WO03076461 PAGE: 51 claimed protein
• <span class="text-smallcaps">D</smallcap>-Phenylalanyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-arginyl chloromethyl ketone
• <span class="text-smallcaps">D</smallcap>-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">D</span>-Phenylalanyl-prolyl-arginyl chloromethyl ketone
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, (S)-
• D-Phe-pro-arg CH2Cl
• D-Phenylalanine-proline-arginine methyl chloride
• D-phenylalanyl-N-{(1S)-1-(chloroacetyl)-4-[(diaminomethylidene)amino]butyl}-L-prolinamide
• H-D-Phe-Pro-Arg-Chloromethylketone Trifluoroacetate Salt
• L-Prolinamide, D-phenylalanyl-N-(4-((aminoiminomethyl)amino)-1-(chloroacetyl)butyl)-, (S)-
• Pebac
• Phe-pro-arg-methyl chloride
• Phenylalanyl-prolyl-arginine methyl chloride
• Ppack
• L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
• D-Phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone
• D-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-prolinamide
• L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-
• H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT USP/EP/BP
• H-D-Phe-Pro-Arg-CMK
• phenylalanyl-prolyl-argininemethylchloride
• D-Phe-Pro-Arg-CMK.TFA
• H-D-PHE-PRO-ARG-CMK TFA

H-D-Phe-Pro-Arg-chloromethylketone

CAS: 71142-71-7

PPACK, fPR-CMK, a highly effective irreversible inhibitor of thrombin and gingipain R.

Formula: C₂₁H₃₁ClN₆O₃

Purezza: 91.3%

Colore e forma: Yellowish Powder

Peso molecolare: 450.97

Ref: 01-4033019

D-Phenylalanyl-prolyl-arginyl chloromethyl ketone

CAS: 71142-71-7

D-Phenylalanyl-prolyl-arginyl chloromethyl ketone is a chemical compound that inhibits the proteolytic activity of serine proteases. It binds to the thrombin receptor on the surface of cells and prevents activation of fibrinogen by thrombin, which is an enzyme that promotes clotting. D-Phenylalanyl-prolyl-arginyl chloromethyl ketone also blocks platelet aggregation and has shown an ability to induce muscle cell proliferation. This drug has been used in pharmacological experiments as an inhibitor binding agent.

Formula: C₂₁H₃₁ClN₆O₃

Purezza: Min. 90 Area-%

Colore e forma: Powder

Peso molecolare: 450.96 g/mol

Ref: 3D-FP46717

PPACK

CAS: 71142-71-7

PPACK: synthetic peptide, irreversibly inhibits thrombin (Ki = 0.24 nM), prevents platelet activation.

Formula: C₂₁H₃₁ClN₆O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 450.96

Ref: TM-T20505