CAS 716-61-0

Base di cloramfenicolo

Descrizione:

Base di cloramfenicolo, con il numero CAS 716-61-0, è un antibiotico ad ampio spettro originariamente derivato dal batterio Streptomyces venezuelae. È caratterizzato dalla sua capacità di inibire la sintesi proteica batterica legandosi alla subunità 50S del ribosoma batterico, bloccando efficacemente la formazione di legami peptidici. Questo composto è una polvere cristallina bianca a gialla pallida, solubile in acqua e in solventi organici come etanolo e acetone. Il cloramfenicolo presenta un peso molecolare relativamente basso e una struttura unica di nitrobenzene, che contribuisce alle sue proprietà farmacologiche. Sebbene sia efficace contro un'ampia gamma di batteri gram-positivi e gram-negativi, il suo uso è diminuito a causa di potenziali effetti collaterali, tra cui anemia aplastica e sindrome del bambino grigio nei neonati. Il cloramfenicolo è ancora utilizzato in situazioni cliniche specifiche, in particolare per il trattamento della febbre tifoide e di alcune infezioni gravi quando altri antibiotici sono inefficaci. Il suo uso è regolamentato in molti paesi a causa di preoccupazioni per la sicurezza, sottolineando l'importanza di un attento monitoraggio quando prescritto.

Formula: C₉H₁₂N₂O₄

InChI: InChI=1/C9H12N2O4/c10-8(5-12)9(13)6-1-3-7(4-2-6)11(14)15/h1-4,8-9,12-13H,5,10H2/p+1/t8-,9-/m1/s1

InChI key: InChIKey=OCYJXSUPZMNXEN-RKDXNWHRSA-N

SMILES: [C@@H]([C@@H](CO)N)(O)C1=CC=C(N(=O)=O)C=C1

Sinonimi:

• (-)-threo-1-(p-Nitrophenyl)-2-amino-1,3-propanediol
• (1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol
• (1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-aminium
• (1R,2R)-2-Amino-1-(4-Nitrophenol)Propane-1,3-Diol
• (1R,2R)-2-Amino-1-(4-Nitrophenyl)Propane-1,3-Diol
• (1R,2R)-threo-(-)-1-(4-Nitrophenyl)-2-amino-1,3-propanediol
• 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-
• 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, [R-(R*,R*)]-
• 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, <span class="text-smallcaps">D</span>-threo-(-)-
• <span class="text-smallcaps">D</span>-(-)-threo-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-(-)-trans-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-1-(p-Nitrophenyl)-2-aminopropane-1,3-diol
• <span class="text-smallcaps">D</span>-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
• <span class="text-smallcaps">D</span>-threo-(1R,2R)-1-p-Nitrophenyl-2-amino-1,3-propanediol
• <span class="text-smallcaps">D</span>-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• Amino-1-(4-nitrophenyl)propane-1,3-diol, (1R,2R)-2-
• Aminonitrophenolpropanediol
• Chloramphenicol D base
• Chloramphenicol base
• Chloramphenicol-Water Soluble
• D(-)Threo-1-(4-Nitro-Phenyl)-2-Amino-1,3-Propanediol
• D-(-)-Threo-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol
• D-Threo-(-)-2-Amino-1-(P-Nitrophenyl)-1,3-Propanediol
• L-Base
• Levoamine
• 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-
• (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol,96%
• Chloramphenicol base, D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• (1R,2R)-1-(4-Nitrophenyl)-2-aminopropane-1,3-diol
• D
• (1R,2R)-2-AMino-1-(4-nitrophenyl)propane-1,3-diol, 96% 5GR
• chloramphenicolbase
• (1R,2R)-(-)-2-AMINO-1-NITROPHENYL)-1,3-PROPANEDIOL
• (1R,2R)-()-2-Amino-1-(4-nitrophenyl)-1,3-propanediol,D-()-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, Chloramphenicol base
• -2-Amino-1-(4-nitrophenyl)-1,3-propanediol
• [1R,2R,(-)]-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
• D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol
• (1R,2R)-(-)-2-AMINO-1-ITROPHENYL)-1,3-PR OPANEDIOL,99%
• D-THREO-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANE
• L-BASE (AMINODIOL)
• (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol hydrochloride
• D(-)Threo-1-(4-nitro-phenyl)-2
• -(-)-
• 2-amino-1-(p-nitrophenyl)-3-propanediod-threo-(-)-
• CHLORAMPHENICOL BASE CRYSTALLINE
• Chloromycin base
• (R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
• (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol, 96%, 96%
• (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol 99%
• threo

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 212.2026

Ref: IN-DA005QRY

Chloramphenicol EP Impurity A

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Colore e forma: Off-White Solid

Peso molecolare: 212.21

Ref: 4Z-C-10104

(1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol

CAS: 716-61-0

(1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol

Purezza: 98%

Peso molecolare: 212.2g/mol

Ref: 54-OR1029092

(1R,2R)-(-)-2-Amino-1-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purezza: ≥ 98.0%

Colore e forma: White to off-white or pale yellow-orange powder or crystals

Peso molecolare: 212.21

Ref: 7W-GK6757

Chloramphenicol EP Impurity A

Prodotto controllato

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Colore e forma: Neat

Peso molecolare: 212.20

Ref: 86-MM0516.01

D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Purezza: >98.0%(T)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 212.21

Ref: 3B-A1017

Chloramphenicol EP Impurity A

CAS: 716-61-0

Formula: C₉H₁₂N₂O₄

Peso molecolare: 212.21

Ref: ST-EA-CP-C161001

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Applications D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuelae.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mehta, J., et al.: J. Biotechnol., 155, 361 (2011); Samsonova, J.V., et al.: Anal. Lett., 43, 133 (2010); Cravedi, J. P., et al.: Chem. Res. Toxciol., 8, 642 (1995); Wal, J.M., et al.: Antimicrob. Agent. Chemother., 24, 89 (1983);

Formula: C₉H₁₂N₂O₄

Colore e forma: Off-White To Light Yellow

Peso molecolare: 212.20

Ref: TR-A622680

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

CAS: 716-61-0

Purezza: 98%

Peso molecolare: 212.21

Ref: 10-F790946

D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol

Prodotto controllato

CAS: 716-61-0

Applications D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol is an intermediate in the synthesis of Chloramphenicol-d5 (C325033), the labeled analogue of Chloramphenicol (C325030), which has a broad spectrum of activity against Gram-positive and gram-negative bacteria. It is also antibacterial, and antirickettsial.
References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

Formula: C₉D₄H₈N₂O₄

Colore e forma: Neat

Peso molecolare: 216.227

Ref: TR-A622682