CAS 71610-00-9

Cefalomannina

Descrizione:

Cefalomannina è un composto naturale classificato come un tipo di alcaloide, specificamente derivato dalla specie vegetale *Cephalotaxus*, comunemente nota come tasso prugna. Questo composto è caratterizzato dalla sua complessa struttura molecolare, che include più anelli e gruppi funzionali che contribuiscono alla sua attività biologica. Cefalomannina presenta notevoli proprietà farmacologiche, inclusi potenziali effetti anti-cancro e immunomodulatori, rendendolo di interesse nella chimica medicinale e nella ricerca farmaceutica. Il suo meccanismo d'azione spesso implica interazione con vie cellulari, influenzando la proliferazione cellulare e l'apoptosi. Il composto è tipicamente studiato nel contesto delle sue applicazioni terapeutiche, in particolare in oncologia. Inoltre, Cefalomannina è solubile in solventi organici, il che è rilevante per la sua estrazione e formulazione in varie applicazioni. Come molti prodotti naturali, lo studio di Cefalomannina include anche indagini sulla sua biosintesi e sui ruoli ecologici che può svolgere all'interno della sua specie vegetale nativa. In generale, Cefalomannina rappresenta un'area significativa di interesse per i ricercatori che esplorano composti naturali con potenziali benefici per la salute.

Formula: C₄₅H₅₃NO₁₄

InChI: InChI=1/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

InChI key: InChIKey=DBXFAPJCZABTDR-WBYYIXQISA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(/C(=C/C)/C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinonimi:

• (2alpha,3xi,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-[(2-methylbut-2-enoyl)amino]-3-phenylpropanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, alpha-hydroxy-beta-(((2E)-2-methyl-1-oxo-2-butenyl)amino)-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
• Benzenepropanoic acid, alpha-hydroxy-beta-((2-methyl-1-oxo-2-butenyl)amino)-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(aR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
• Benzenepropanoic acid, α-hydroxy-β-[(2-methyl-1-oxo-2-butenyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-butenyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Nsc 318735
• Taxol B
• Cephalomannine
• Cephalomannine, 98%, from Taxus chinensis (Pilg.) Rehder
• CEPHALOMANNINE (TAXOL B)
• 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, ...
• Paclitaxel Impurity 2（Paclitaxel EP Impurity B）
• CEPHALOMANNINE(P)
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...
• Paclitaxel Related CoMpound A
• CephaloMannine, froM Taxus chinensis
• Paclitaxel EP Impurity B
• BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-
• BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-
• Cephalomannine, >99%
• paclitaxel iMpurity I
• Paclitaxel Impurity Ⅰ:Cephalomannine
• N-Debenzoyl-N-tigloylpaclitaxel
• N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)
• Paclitaxel Related Compound A (Cephalomannine)
• 3′-N-(trans-2-methyl-2-butenoyl)-3′-N-debenzoylpaclitaxel
• N-Debenzoyl-N-tigloylpaclitaxel (Ce
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1
• Cephalomannine 71610-00-9
• -[(2-methyl-1-oxo-2-butenyl)amino]-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,[2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoicacid, α-hydroxy-β
• Cephalomannine USP/EP/BP
• Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)

Paclitaxel Related Compound A (Cephalomannine)

CAS: 71610-00-9

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₅H₅₃NO₁₄

Colore e forma: White Off-White Powder

Peso molecolare: 831.34661

Ref: 45-1491343

Cephalomannine

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Peso molecolare: 831.90

Ref: 7W-GA4112

Cephalomannine (Paclitaxel USP Related Compound A)

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 831.91

Ref: 4Z-C-11901

Cephalomannine

CAS: 71610-00-9

Cephalomannine

Purezza: ≥98%

Peso molecolare: 831.9g/mol

Ref: 54-BUP00025

N-Debenzoyl-N-tigloylpaclitaxel (Cephalomannine)

CAS: 71610-00-9

Colore e forma: Neat

Ref: 86-MM1489.02

Cephalomannine

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Purezza: 95%~99%

Peso molecolare: 831.912

Ref: BP-BP0332

Cephalomannine

CAS: 71610-00-9

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Formula: C₄₅H₅₃NO₁₄

Purezza: 98.77% - 99.75%

Colore e forma: Solid

Peso molecolare: 831.9

Ref: TM-T2217

Paclitaxel EP Impurity B

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Peso molecolare: 831.90

Ref: ST-EA-CP-P36145

Cephalomannine

Prodotto controllato

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Colore e forma: White

Peso molecolare: 831.90

Ref: TR-C258500

Cephalomannine

CAS: 71610-00-9

Purezza: 98%

Peso molecolare: 831.912

Ref: 10-F987648

Cephalomannine

CAS: 71610-00-9

Cephalomannine is a diterpenoid alkaloid product, which is derived from the needles of the Taxus species, commonly known as yew trees. It is structurally similar to paclitaxel (Taxol), a well-known chemotherapeutic agent. The mode of action of cephalomannine involves binding to the β-subunit of tubulin, thereby promoting the polymerization of tubulin into stable microtubules while simultaneously inhibiting their depolymerization. This stabilization of the microtubule network disrupts the normal process of cell division, effectively arresting cell mitosis, which leads to cell death.

Formula: C₄₅H₅₃NO₁₄

Purezza: Min. 95%

Peso molecolare: 831.9 g/mol

Ref: 3D-FC19896

Cephalomannine

CAS: 71610-00-9

Formula: C₄₅H₅₃NO₁₄

Peso molecolare: 831.91

Ref: ST-EA-CP-C548004

Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

CAS: 71610-00-9

Formula: C₃₇H₄₃NO₁₀

Colore e forma: Solid

Peso molecolare: 661.7380

Ref: IN-DA0038H4