CAS 71827-03-7

Ivermectina B1a

Descrizione:

Ivermectina B1a, con il numero CAS 71827-03-7, è una lattone macrociclica derivata dalla fermentazione del batterio del suolo Streptomyces avermitilis. È un potente agente antiparassitario utilizzato principalmente in medicina veterinaria e ha applicazioni in medicina umana per il trattamento di varie infezioni parassitarie. Ivermectina B1a mostra un ampio spettro di attività contro nematodi ed ectoparassiti, inclusi pidocchi e scabbia. Il composto funziona legandosi ai canali del cloro attivati dal glutammato, portando a un aumento della permeabilità della membrana cellulare agli ioni di cloro, risultando in paralisi e morte dei parassiti. L'ivermectina è generalmente ben tollerata, con un profilo di sicurezza favorevole, anche se può causare effetti collaterali in alcuni individui, particolarmente a dosi più elevate. La sostanza è tipicamente somministrata per via orale o topica, a seconda del tipo di infezione trattata. La sua efficacia e sicurezza l'hanno resa un componente critico nelle iniziative di salute globale, in particolare nella lotta contro le malattie tropicali trascurate.

Formula: C₄₈H₇₄O₁₄

InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key: InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES: O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]

Sinonimi:

• (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside
• 22,23-Dihydro-5-O-demethylavermectin A1a
• 22,23-Dihydroavermectin B(1)a
• 22,23-Dihydroavermectin B1a
• 22,23-Dihydroavermectin B_1a
• 5-O-Demethyl-22,23-dihydroavermectin A_1a
• Avermectin A1a, 22,23-dihydro-5-O-demethyl-
• Avermectin A_1a, 5-O-demethyl-22,23-dihydro-
• Brn 4643153
• Dihydroavermectin B1a
• Dihydroavermectin B_1a
• Ivermectin B1a
• Ivermectin B_1a
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-91Y2202Ouw
• Avermectin A1a, 5-O-demethyl-22,23-dihydro-
• 5-O-Demethyl-22,23-dihydroavermectin A1a

Ivermectin B1a-d2

CAS: 71827-03-7

Formula: C₄₈H₇₂D₂O₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 877.12

Ref: 4Z-I-077008

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a

Purezza: ≥98%

Peso molecolare: 875.09g/mol

Ref: 54-BUP00618

Ivermectin B1a

CAS: 71827-03-7

Formula: C₄₈H₇₄O₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 875.11

Ref: 4Z-I-077016

Ivermectine B1a

CAS: 71827-03-7

Colore e forma: Neat

Ref: 04-CA14488005

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Formula: C₄₈H₇₄O₁₄

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 875.09

Ref: TM-T21727

Ivermectin B1a-D2

Prodotto controllato

CAS: 71827-03-7

Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Formula: C₄₈H₇₂D₂O₁₄

Colore e forma: Neat

Peso molecolare: 877.11

Ref: TR-I940817

Ivermectin B1a (>85%)

Prodotto controllato

CAS: 71827-03-7

Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Formula: C₄₈H₇₄O₁₄

Purezza: >85%

Colore e forma: Neat

Peso molecolare: 875.09

Ref: TR-I940815

Ivermectin B1a-D2

CAS: 71827-03-7

Ivermectin is a broad-spectrum antiparasitic agent that is used to treat onchocerciasis and other infectious diseases. It binds selectively to gamma-aminobutyric acid (GABA) receptors in the central nervous system and inhibits the release of neurotransmitters, thereby inhibiting the inflammatory response. Ivermectin has been shown to be safe for use in humans and has a long half-life that allows for once-weekly administration. This drug also has pharmacokinetic properties that are similar among different species and clinical studies have shown no significant differences between human and animal models. Ivermectin is applied topically as an ointment or cream or orally as tablets or capsules, depending on the condition being treated.

Formula: C₄₈H₇₂D₂O₁₄

Purezza: Min. 95%

Peso molecolare: 877.11 g/mol

Ref: 3D-WCA82703

Ivermectin 2-epimer

CAS: 71827-03-7

Formula: C₄₈H₇₄O₁₄

Peso molecolare: 875.11

Ref: ST-EA-CP-I18017