CAS 7195-27-9

mefruside

Descrizione:

mefruside, con il numero CAS 7195-27-9, è un composto chimico classificato come sulfonamide. È principalmente riconosciuto per le sue proprietà diuretiche, che lo rendono utile nel trattamento di condizioni come l'ipertensione e l'edema. mefruside agisce inibendo il riassorbimento del sodio nei reni, portando a un aumento della produzione di urina e a una riduzione del volume sanguigno. Il composto viene tipicamente somministrato per via orale ed è noto per il suo inizio d'azione relativamente rapido. In termini di struttura chimica, mefruside contiene un gruppo sulfonamide, caratteristico di molti diuretici, e può presentare vari gruppi funzionali che contribuiscono alla sua attività farmacologica. Come per molti farmaci, gli effetti collaterali potenziali possono includere squilibri elettrolitici, disidratazione e reazioni allergiche. È essenziale che i pazienti siano monitorati mentre assumono mefruside per garantire sicurezza ed efficacia. In generale, mefruside è un agente importante nella gestione di alcune condizioni cardiovascolari, riflettendo il ruolo più ampio delle sulfonamidi nella chimica medicinale.

Formula: C₁₃H₁₉ClN₂O₅S₂

InChI: InChI=1/C13H19ClN2O5S2/c1-13(6-3-7-21-13)9-16(2)23(19,20)10-4-5-11(14)12(8-10)22(15,17)18/h4-5,8H,3,6-7,9H2,1-2H3,(H2,15,17,18)

InChI key: InChIKey=SMNOERSLNYGGOU-UHFFFAOYSA-N

SMILES: C(N(S(=O)(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1)C)C2(C)CCCO2

Sinonimi:

• 1,3-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-((tetrahydro-2-methyl-2-furanyl)methyl)-
• 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-((tetrahydro-2-methyl-2-furanyl)methyl)-
• 1,3-Benzenedisulfonamide, 4-chloro-N¹-methyl-N¹-[(tetrahydro-2-methyl-2-furanyl)methyl]-
• 4-Chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N-methyl-N-(2-methyltetrahydrofurfuryl)-1,3-benzenesulfonamide
• 4-Chloro-N¹-methyl-N¹-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N¹-methyl-N¹-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
• 4-chloro-N~1~-methyl-N~1~-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
• B 1500
• Bay 1500
• Baycaron
• Fba 1500
• Fda 1902
• Mefrusal
• Mefrusid
• Mefrusida
• Mefrusida [INN-Spanish]
• Mefruside [USAN:INN:BAN:JAN]
• Mefrusidum
• Mefrusidum [INN-Latin]
• N-(4'-Chloro-3'-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran
• N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine
• m-Benzenedisulfonamide, 4-chloro-N(sup 1)-methyl-N(sup 1)-(tetrahydro-2-methylfurfuryl)-
• m-Benzenedisulfonamide, 4-chloro-N¹-methyl-N¹-(tetrahydro-2-methylfurfuryl)-
• Mefruside
• m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-
• 4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide
• 4-Chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
• 4-Chloro-N-methyl-N-(tetrahydro-2-methylfuran-2-yl)-1,3-benzenedisulfonamide
• 4-chloro-N-methyl-N-[(2-methyltetrahydrofuran-2-yl)methyl]benzene-1,3-disulfonamide
• 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]- (9CI)
• 4-chloro-1-N-methyl-1-N-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide
• mefruside USP/EP/BP
• 4-chloro-N1-methyl-N1-[(2-methyloxolan-2-yl)methyl]benzene-1,3-disulfonamide

Mefruside 1.0 mg/ml in Methanol

CAS: 7195-27-9

Colore e forma: Single Solution

Ref: 61-AMP1399.00-01

Mefruside

CAS: 7195-27-9

Formula: C₁₃H₁₉ClN₂O₅S₂

Peso molecolare: 382.89

Ref: 4Z-M-144001

Mefruside

Prodotto controllato

CAS: 7195-27-9

Stability Hygroscopic
Applications Mefruside is a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Formula: C₁₃H₁₉ClN₂O₅S₂

Colore e forma: Off-White

Peso molecolare: 382.88

Ref: TR-M205150

Mefruside-d3

Prodotto controllato

CAS: 7195-27-9

Stability Hygroscopic
Applications Isotope labelled analogue of Mefruside (M205150), a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Formula: C₁₃H₁₆D₃ClN₂O₅S₂

Colore e forma: White To Light Beige

Peso molecolare: 385.9

Ref: TR-M205152

Mefruside

CAS: 7195-27-9

Mefruside is a drug that belongs to the class of anti-inflammatory drugs and is used to treat bowel disease, cardiac diseases, and blood vessel diseases. Mefruside has been shown to be effective in treating infectious diseases and lowering diastolic pressure. Mefruside lowers systolic pressure by acid formation and prevents autoimmune diseases. It also has long-term efficacy for blood sampling and glomerular filtration rate, as well as inflammatory bowel disease. Mefruside may cause liver cell damage and high sodium levels in the body.

Formula: C₁₃H₁₉ClN₂O₅S₂

Purezza: Min. 95%

Peso molecolare: 382.89 g/mol

Ref: 3D-HAA19527

Mefruside

CAS: 7195-27-9

Mefruside is an orally effective diuretic that reduces tubular reabsorption of electrolytes and water, studying edema and hypertension.

Formula: C₁₃H₁₉ClN₂O₅S₂

Purezza: 99.29%

Colore e forma: Solid

Peso molecolare: 382.88

Ref: TM-T33276