CAS 72063-39-9

Spinosina

Descrizione:

Spinosina, con il numero CAS 72063-39-9, è un composto naturale derivato principalmente dalla specie vegetale *Ziziphus jujuba*, comunemente nota come giuggiola. Appartiene alla classe dei flavonoidi ed è riconosciuto per le sue potenziali proprietà farmacologiche. Spinosina è caratterizzato dalla sua unica struttura chimica, che include uno scheletro di flavone, contribuendo alla sua bioattività. Questo composto ha suscitato interesse nel campo della medicina erboristica grazie ai suoi effetti ansiolitici, sedativi e neuroprotettivi riportati. Inoltre, Spinosina presenta proprietà antiossidanti, che possono aiutare a mitigare lo stress ossidativo nei sistemi biologici. Il suo profilo di solubilità suggerisce che è più solubile nei solventi organici che in acqua, il che può influenzare la sua biodisponibilità e le applicazioni terapeutiche. La ricerca su Spinosina continua a esplorare i suoi meccanismi d'azione e i potenziali benefici nel trattamento di varie condizioni di salute, in particolare quelle legate all'ansia e ai disturbi del sonno. In generale, Spinosina rappresenta un'area significativa di interesse nella chimica dei prodotti naturali e nella farmacologia.

Formula: C₂₈H₃₂O₁₅

InChI: InChI=1S/C28H32O15/c1-39-14-7-15-18(12(32)6-13(40-15)10-2-4-11(31)5-3-10)22(35)19(14)26-27(24(37)21(34)16(8-29)41-26)43-28-25(38)23(36)20(33)17(9-30)42-28/h2-7,16-17,20-21,23-31,33-38H,8-9H2,1H3/t16-,17-,20-,21-,23+,24+,25-,26+,27-,28+/m1/s1

InChI key: InChIKey=VGGSULWDCMWZPO-ODEMIOGVSA-N

SMILES: O(C)C1=C(C(O)=C2C(=C1)OC(=CC2=O)C3=CC=C(O)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4

Sinonimi:

• (1S)-1,5-Anhydro-2-O-beta-D-glucopyranosyl-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol
• 4H-1-Benzopyran-4-one, 6-(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 4H-1-Benzopyran-4-one, 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 6-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• D-glucitol, 1,5-anhydro-2-O-beta-D-glucopyranosyl-1-C-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-
• Flavoayamenin
• Spinosin
• Swertisin 2′′-O-glucoside
• 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 6-(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-

Spinosin

CAS: 72063-39-9

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₂₈H₃₂O₁₅

Colore e forma: Yellow Powder

Peso molecolare: 608.17412

Ref: 45-1618717

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 608.5447

Ref: IN-DA00FBG1

Spinosin

CAS: 72063-39-9

Spinosin

Purezza: ≥98%

Peso molecolare: 608.54g/mol

Ref: 54-BUP00112

Spinosin

CAS: 72063-39-9

Spinosin

Purezza: 95%

Peso molecolare: 608.54g/mol

Ref: 54-OR1024110

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Peso molecolare: 608.55

Ref: 7W-GY0454

Spinosin

CAS: 72063-39-9

Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.

Formula: C₂₈H₃₂O₁₅

Purezza: 95%~99%

Peso molecolare: 608.549

Ref: BP-BP1336

Spinosin

CAS: 72063-39-9

Formula: C₂₈H₃₂O₁₅

Purezza: >95.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 608.55

Ref: 3B-P2887

Spinosin

CAS: 72063-39-9

1.

Formula: C₂₈H₃₂O₁₅

Purezza: 98.16% - 99.75%

Colore e forma: Solid

Peso molecolare: 608.54

Ref: TM-T6S2227

Spinosin

CAS: 72063-39-9

Natural glycoside

Formula: C₂₈H₃₂O₁₅

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 608.55

Ref: 5G-83284

Spinosin

Prodotto controllato

CAS: 72063-39-9

Applications Spinosin is a C-glycoside flavonoid extracted from Zizhiphi Spinozae, improved pentobarbital-induced sleep.
References Wang, Li. et al.: Pharm. Biochem. Behav., 90, 399 (2008);

Formula: C₂₈H₃₂O₁₅

Colore e forma: Neat

Peso molecolare: 608.54

Ref: TR-S681950

Spinosin

CAS: 72063-39-9

Spinosin is a natural product that belongs to the group of pyrrolizidine alkaloids. It has been shown to have physiological function as it can inhibit the 5-HT1A receptor and thereby regulate neurotransmitter release. Spinosin also has anti-inflammatory effects and can be used in the treatment of skin disorders, such as psoriasis. In vitro studies have shown that spinosin is a substrate for P-gp and interacts with other drugs by inhibiting their absorption in the gut and liver. Spinosin has been found to bind to monoclonal antibodies, which may be due to its structural similarity to chinese herb, a known antigenic protein. This leads to increased uptake of spinosin into cells and thus makes it an analytical method for measuring spinosin in biological samples. Spinosin activates p38mapk which then causes the phosphorylation of ERK1/2, leading to receptor binding and activation of downstream signaling pathways.

Formula: C₂₈H₃₂O₁₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 608.54 g/mol

Ref: 3D-FS65586