CAS 73030-71-4

Atractilenolide III

Descrizione:

Atractilenolide III è un composto bioattivo derivato principalmente dalle radici dell'erba medicinale cinese tradizionale Atractylodes macrocephala. Appartiene alla classe dei sesquiterpeni ed è caratterizzato dalla sua unica struttura chimica, che contribuisce alle sue varie proprietà farmacologiche. Questo composto è noto per i suoi potenziali effetti anti-infiammatori, anti-cancro e immunomodulatori, rendendolo di interesse sia nella medicina tradizionale che nella ricerca farmacologica moderna. Atractilenolide III mostra una gamma di attività biologiche, inclusa la capacità di inibire alcuni enzimi e modulare le vie di segnalazione, il che può contribuire ai suoi effetti terapeutici. Inoltre, è stato studiato per i suoi effetti protettivi contro lo stress ossidativo e il suo ruolo nel migliorare le risposte immunitarie. Il composto viene tipicamente estratto e purificato per scopi di ricerca, e il suo profilo di sicurezza è generalmente considerato favorevole, sebbene siano necessari ulteriori studi per comprendere appieno i suoi meccanismi d'azione e le potenziali applicazioni in contesti clinici.

Formula: C₁₅H₂₀O₃

InChI: InChI=1/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

InChI key: InChIKey=FBMORZZOJSDNRQ-GLQYFDAESA-N

SMILES: O[C@@]12C(C[C@@]3([C@@](C)(C1)CCCC3=C)[H])=C(C)C(=O)O2

Sinonimi:

• (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9a-hydroxy-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
• 8β-Hydroxyasterolide
• Atractylenolide III
• Atractylenolide β
• Codonolactone
• Naphtho(2,3-b)furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
• Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, [4aS-(4aα,8aβ,9aβ)]-
• Atractylenolide III, BR
• (4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzoxol-2-one
• Atractylenolide beta
• 8-HYDROXYASTEROLIDE
• ICodonolactone
• Atracylenolide III
• ATRACTYLENOLIDE
• (4aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9aβ-hydroxy-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• Atractylenolide III (ICodonolactone
• Atractylenolide III USP/EP/BP

Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-,(4aS,8aR,9aS)-

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 248.3175

Ref: IN-DA00ICC9

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III

Purezza: ≥98%

Peso molecolare: 248.32g/mol

Ref: 54-BUP10043

Atractylenolide III

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Peso molecolare: 248.32

Ref: 7W-GL2829

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III is the major bioactive component of Atractylodes lancea, it inhibits histamine release, suppresses activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB in stimulated HMC-1 cells, and suppresses the activation of caspase-1 and the expression of receptor interacting protein-2, suggests that atractylenolide III may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

Formula: C₁₅H₂₀O₃

Purezza: 95%~99%

Colore e forma: White cryst.

Peso molecolare: 248.322

Ref: BP-BP0216

Atractylenolide III

CAS: 73030-71-4

Formula: C₁₅H₂₀O₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 248.32

Ref: 3B-A3609

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III could treat cognitive issues and lung cancer by modulating apoptosis factors.

Formula: C₁₅H₂₀O₃

Purezza: 99.53% - 99.82%

Colore e forma: Solid

Peso molecolare: 248.32

Ref: TM-T3902

Atractylenolide iii

CAS: 73030-71-4

Lactone

Formula: C₁₅H₂₀O₃

Purezza: ≥ 98.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 248.32

Ref: 5G-80359

ATRACTYLENOLIDE III

CAS: 73030-71-4

Purezza: 98%

Peso molecolare: 248.3220062

Ref: 10-F809712

AtractylenolideIII

CAS: 73030-71-4

Atractylenolide III is a sesquiterpene lactone, which is derived from the rhizomes of Atractylodes macrocephala, a plant commonly used in traditional Chinese medicine. With its origin in botanical sources, the compound is notable for its diverse biological activities and mechanisms of action. Atractylenolide III exerts its effects primarily through the modulation of various signaling pathways, including anti-inflammatory, anti-cancer, and immunomodulatory pathways. It inhibits the production of pro-inflammatory cytokines and regulates the expression of key signaling proteins, thus impacting cellular processes such as proliferation, apoptosis, and differentiation. The compound shows promise in the treatment of conditions like cancer, inflammation, and immune disorders. Researchers continue to explore its potential benefits, seeking to elucidate the molecular mechanisms underlying its therapeutic effects and to optimize its application in various biomedical fields.

Purezza: Min. 95%

Ref: 3D-FA73865