CAS 73232-52-7

Bromuro di metilnaltrexone

Descrizione:

Bromuro di metilnaltrexone è un derivato dell'ammonio quaternario della naltrexone, utilizzato principalmente come farmaco per trattare la costipazione indotta da oppioidi, in particolare nei pazienti con malattie avanzate. Funziona come un antagonista del recettore mu-opioide ad azione periferica, il che significa che blocca gli effetti degli oppioidi nel tratto gastrointestinale senza influenzare il sollievo dal dolore nel sistema nervoso centrale. Questa azione selettiva aiuta ad alleviare la costipazione senza invertire l'analgesia. Bromuro di metilnaltrexone viene tipicamente somministrato tramite iniezione sottocutanea e ha un rapido inizio d'azione. La sua struttura chimica include un gruppo metile attaccato all'atomo di azoto della struttura portante della naltrexone, che ne migliora la solubilità e le proprietà farmacocinetiche. La sostanza è generalmente ben tollerata, con effetti collaterali comuni che includono dolore addominale, diarrea e nausea. A causa del suo specifico meccanismo d'azione, è particolarmente utile per i pazienti che sono in terapia cronica con oppioidi e sperimentano costipazione come effetto collaterale. Bromuro di metilnaltrexone è classificato come un farmaco da prescrizione e deve essere utilizzato sotto supervisione medica.

Formula: C₂₁H₂₆NO₄·Br

InChI: InChI=1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1

InChI key: InChIKey=IFGIYSGOEZJNBE-KNLJMPJLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2([N+](CC6CC6)(C)CC4)[H].[Br-]

Sinonimi:

• (17RS)-17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-17-methyl-6- oxomorphinanium bromide
• (5Alpha)-17-(Cyclopropylmethyl)-3,14-Dihydroxy-17-Methyl-4,5-Epoxymorphinan-17-Ium-6-One Bromide
• Methylnaltrexone bromide [USAN]
• Moa-728
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide (1:1), (5α)-
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide, (5alpha)-
• Mrz 2663
• Mrz 2663Br
• N-Cyclopropylmethyl-noroxymorphone methobromide
• N-Methylnaltrexone bromide
• Naltrexone methobromide
• Naltrexone methyl bromide
• Relistor
• Unii-Rfo6Il3D3M

Methylnaltrexone Bromide

CAS: 73232-52-7

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₂₁H₂₆BrNO₄

Colore e forma: White Off-White Powder

Peso molecolare: 435.10452

Ref: 45-1430735

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide

Purezza: ≥98%

Peso molecolare: 436.35g/mol

Ref: 54-BUP05752

Methyl Naltrexone-d3 Bromide (Mixture of Diastereomers)

CAS: 73232-52-7

Formula: C₂₁H₂₃D₃NO₄·Br

Peso molecolare: 359.46 79.90

Ref: 4Z-N-0135

Methylnaltrexone Bromide

CAS: 73232-52-7

Formula: C₂₁H₂₆NO₄·Br

Peso molecolare: 356.44 79.90

Ref: 4Z-N-0140

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists, acts to reverse the side effects of opioid drugs.

Formula: C₂₁H₂₆BrNO₄

Purezza: 99.02%

Colore e forma: Solid

Peso molecolare: 436.35

Ref: TM-T21422

N-Methyl Naltrexone-d3 Bromide

Prodotto controllato

CAS: 73232-52-7

Applications A labelled metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007),

Formula: C₂₁H₂₃D₃BrNO₄

Colore e forma: Neat

Peso molecolare: 439.36

Ref: TR-M320352

N-Methyl Naltrexone Bromide

Prodotto controllato

CAS: 73232-52-7

Stability Hygroscopic
Applications A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Formula: C₂₁H₂₆BrNO₄

Colore e forma: Neat

Peso molecolare: 436.35

Ref: TR-M320350

Methylnaltrexone Bromide

CAS: 73232-52-7

Formula: C₂₁H₂₆BrNO₄

Purezza: >95.0%(HPLC)(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 436.35

Ref: 3B-M3504

N-Methyl naltrexone bromide

Prodotto controllato

CAS: 73232-52-7

N-Methyl naltrexone bromide is an opioid antagonist that binds to opioid receptors, preventing the binding of other opioid agonists. It has been shown to be effective in long-term treatment of chronic pain and may be used in combination with opioids for patients with hepatic impairment. The efficacy of N-methyl naltrexone bromide in treating constipation has not been established. This drug should not be used in patients with HIV infection because it may reduce the effectiveness of antiretroviral therapy. The pharmacokinetics and safety profile of this drug have been studied extensively, which showed no serious adverse effects. Histological analysis revealed that N-methyl naltrexone bromide did not affect epithelial mesenchymal cells or the intestinal villi.

Formula: C₂₁H₂₆BrNO₄

Purezza: Min. 95%

Peso molecolare: 436.34 g/mol

Ref: 3D-FM25532