CAS 73384-59-5

Ceftriaxone

Descrizione:

Ceftriaxone è un antibiotico cefalosporinico ad ampio spettro utilizzato principalmente per trattare una varietà di infezioni batteriche. È caratterizzato dalla sua capacità di inibire la sintesi della parete cellulare batterica, rendendolo efficace contro batteri sia Gram-positivi che Gram-negativi. Ceftriaxone viene tipicamente somministrato per via intramuscolare o endovenosa a causa della sua scarsa biodisponibilità orale. Ha una lunga emivita, consentendo una somministrazione una volta al giorno in molti casi. La sostanza è solubile in acqua, il che facilita il suo utilizzo in contesti clinici. Ceftriaxone è noto per la sua stabilità contro alcune beta-lattamasi, enzimi prodotti da alcuni batteri che conferiscono resistenza ad altri antibiotici. Tuttavia, non è efficace contro tutti i ceppi batterici e può svilupparsi resistenza. Gli effetti collaterali comuni possono includere reazioni allergiche, disturbi gastrointestinali e alterazioni nei test di funzionalità epatica. Grazie alla sua ampia attività, Ceftriaxone è spesso utilizzato nel trattamento di infezioni gravi, tra cui polmonite, meningite e sepsi, ed è un componente critico della terapia empirica in molte linee guida cliniche.

Formula: C₁₈H₁₈N₈O₇S₃

InChI: InChI=1/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-

InChI key: InChIKey=VAAUVRVFOQPIGI-SPQHTLEESA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC=4N(C)NC(=O)C(=O)N4)[H]

Sinonimi:

• (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-Thiazol-4-Yl)-2-Methoxyiminoacetyl]Amino]-3-[(2-Methyl-5,6-Dioxo-1H-1,2,4-Triazin-3-Yl)Sulfanylmethyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, (6R,7R)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-
• 7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Biotrakson
• Ceftriaxon
• Ceftriaxona
• Epicephin
• Rocefin
• Rocephalin
• Rophex
• Ceftriaxone
• (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Antibiotic Ro-13-9904
• CEFTRIAZONE
• CEFATRIAXONE
• Rocephin(e)

Ceftriaxone Disodium Salt Hemiheptahydrate

CAS: 104376-79-6, 73384-59-5, 74578-69-1

Formula: C₁₈H₁₆N₈Na₂O₇S₃H₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 661.58

Ref: 3B-C2226

Ceftriaxone

CAS: 73384-59-5

Formula: C₁₈H₁₈N₈O₇S₃

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 554.5799

Ref: IN-DA019FVC

Ceftriaxone

CAS: 73384-59-5

Ceftriaxone

Purezza: ≥95%

Peso molecolare: 554.58g/mol

Ref: 54-BUP00460

Ceftriaxone

CAS: 73384-59-5

Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.

Formula: C₁₈H₁₈N₈O₇S₃

Purezza: 96.08%

Colore e forma: Solid

Peso molecolare: 554.58

Ref: TM-T75295

Ceftriaxone Disodium Salt

CAS: 104376-79-6, 73384-59-5

Formula: C₁₈H₁₆N₈O₇S₃·2Na

Peso molecolare: 552.57 2*22.99

Ref: 4Z-C-939

Ceftriaxone

CAS: 73384-59-5

Applications Ceftriaxone is an antibacterial, a third-generation cephalosporin.
References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)

Formula: C₁₈H₁₈N₈O₇S₃

Colore e forma: Off-White To Light Yellow

Peso molecolare: 554.58

Ref: TR-C244995