CAS 73554-84-4

tert-(Butilossicarbonile)-L-valil-L-leucil-L-lisina-7-ammino-4-metilcumarina

Descrizione:

tert-(Butilossicarbonile)-L-valil-L-leucil-L-lisina-7-ammino-4-metilcumarina, comunemente noto come un derivato peptidico, è caratterizzato dalla sua struttura complessa che include un gruppo protettivo carbamato di tert-butile (Boc), spesso utilizzato nella sintesi di peptidi per proteggere i gruppi amminici. La presenza di L-valina, L-leucina e L-lisina indica che si tratta di un peptide sintetico composto da questi amminoacidi, contribuendo alla sua attività biologica e potenziali applicazioni nello sviluppo di farmaci. Il gruppo di 7-amino-4-metilcumarina funge da etichetta fluorescente, rendendo questo composto utile in saggi biochimici e studi che coinvolgono interazioni peptidiche. Questo composto è tipicamente solubile in solventi organici e può mostrare reattività specifica in base ai suoi gruppi funzionali. La sua stabilità e reattività possono essere influenzate da condizioni ambientali come pH e temperatura. In generale, questa sostanza è significativa nei campi della chimica medicinale e della biochimica, in particolare nello sviluppo di terapie basate su peptidi e sonde fluorescenti.

Formula: C₃₂H₄₉N₅O₇

InChI: InChI=1S/C32H49N5O7/c1-18(2)15-24(36-30(41)27(19(3)4)37-31(42)44-32(6,7)8)29(40)35-23(11-9-10-14-33)28(39)34-21-12-13-22-20(5)16-26(38)43-25(22)17-21/h12-13,16-19,23-24,27H,9-11,14-15,33H2,1-8H3,(H,34,39)(H,35,40)(H,36,41)(H,37,42)/t23-,24-,27-/m0/s1

InChI key: InChIKey=KVLPXRKIIFWZLM-DPZBCOQUSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)[C@@H](C)C)=O)CC(C)C)=O)CCCCN)=O)=CC2)OC(=O)C1

Sinonimi:

• 7: PN: WO2004106541 PAGE: 15 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Boc-Val-Leu-Lys-AMC
• Boc-Val-Leu-Lys-Amc Acetate
• N-(tert-butoxycarbonyl)-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide
• N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-<smallcap>L</span>-lysinamide
• tert-(Butyloxycarbonyl)-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</span>-lysine-7-amino-4-methylcoumarin
• tert-(Butyloxycarbonyl)-L-valyl-L-leucyl-L-lysine-7-amino-4-methylcoumarin
• N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
• L-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

A sensitive, fluorogenic, and specific substrate for the quantitative measurement of plasmin. Boc-VLK-AMC is also cleaved by acrosin from the ascidian Halocynthia roretzi, by porcine calpain isozymes I and II, and by papain.

Formula: C₃₂H₄₉N₅O₇

Purezza: 97.7%

Colore e forma: White Lyophilisate

Peso molecolare: 615.77

Ref: 01-4004467

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC is a research tool that has been shown to activate ion channels and increase the permeability of cell membranes. This compound also binds to receptors on cells, which may be due to its ability to bind with antibodies. Boc-Val-Leu-Lys-AMC has been used as an inhibitor in protein interactions and pharmacology studies, as well as for the study of ion channels in cell biology.

Formula: C₃₂H₄₉N₅O₇

Purezza: Min. 95%

Peso molecolare: 615.76 g/mol

Ref: 3D-MVL-3104-V

Boc-Val-Leu-Lys-AMC acetate salt

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC acetate salt is a protease inhibitor that binds to the active site of trypsin and inhibits its proteolytic activity. It has been shown to protect neuronal cells from death caused by amyloid beta (Aβ) peptide. Boc-Val-Leu-Lys-AMC acetate salt also inhibits the secretion of proinflammatory cytokines and reduces the permeability of mitochondrial membranes in human neutrophils. This drug is stable in acidic environments, with a pH optimum of 2.0, but is sensitive to alkaline conditions with a pH optimum of 8.5. Boc-Val-Leu-Lys-AMC acetate salt has been shown to bind to casein, which may result in high values on sephadex g100 chromatography.

Formula: C₃₂H₄₉N₅O₇•C₂H₄O₂

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 675.81 g/mol

Ref: 3D-FB110487