CAS 73573-88-3

Mevastatina

Descrizione:

Mevastatina, noto anche come compactina, è una statina di origine naturale utilizzata principalmente per le sue proprietà di abbassamento del colesterolo. È derivata dalla fermentazione di alcuni funghi, in particolare Penicillium citrinum. La struttura chimica di Mevastatina presenta un anello di lattone e un gruppo acido idrossilico, che sono cruciali per la sua attività biologica. In quanto inibitore della HMG-CoA reduttasi, Mevastatina gioca un ruolo significativo nella via del mevalonato, riducendo efficacemente la sintesi di colesterolo nel fegato. Questa azione aiuta a ridurre i livelli di colesterolo a bassa densità (LDL) nel flusso sanguigno, riducendo così il rischio di malattie cardiovascolari. Mevastatina viene tipicamente somministrato nella sua forma attiva, che è l'acido idrossilico, poiché la forma di lattone viene convertita nella forma attiva nel corpo. Sebbene sia stato utilizzato nella ricerca e abbia un'importanza storica nello sviluppo dei farmaci statine, il suo uso clinico è stato in gran parte sostituito da statine più potenti e ampiamente studiate. Come per tutti i farmaci, è necessario considerare i potenziali effetti collaterali e le interazioni quando si valuta il suo utilizzo.

Formula: C₂₃H₃₄O₅

InChI: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

InChI key: InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N

SMILES: C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@]3([C@@H](OC([C@H](CC)C)=O)CCC=C3C=C[C@@H]2C)[H]

Sinonimi:

• (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 2-Methyl-butanoic acid [1S-[1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
• Antibiotic ML 236B
• Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),7β,8β(2S*,4S*),8aβ]]-
• CS 500 (antibiotic)
• Compactin (Penicillium)
• Cs 500
• L 637312
• ML 236B lactone
• Mevastatin
• Ml-236B
• NSC 281245
• Statin I

Mevastatin

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Yellow to Orange powder to crystal

Peso molecolare: 390.52

Ref: 3B-M2275

Mevastatin, 98%

CAS: 73573-88-3

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close str

Formula: C₂₃H₃₄O₅

Purezza: 98%

Colore e forma: Powder or crystals or crystalline powder

Peso molecolare: 390.52

Ref: 02-J61357

Mevastatin ((1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate)

CAS: 73573-88-3

Lactones, nesoi

Formula: C₂₃H₃₄O₅

Colore e forma: Yellow Pale Yellow Powder

Peso molecolare: 390.24062

Ref: 45-1443216

Mevastatin

CAS: 73573-88-3

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.

Formula: C₂₃H₃₄O₅

Purezza: 99.12%

Colore e forma: White-Yellowish To Yellow Powder Solid Powder

Peso molecolare: 390.51

Ref: TM-T0683

Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 390.5131

Ref: IN-DA0038GT

Mevastatin

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Purezza: ≤ 0.5%

Colore e forma: White to light-yellow crystalline powder

Peso molecolare: 390.52

Ref: 7W-GA8933

Mevastatin

CAS: 73573-88-3

Mevastatin

Purezza: 98%

Peso molecolare: 390.51g/mol

Ref: 54-OR1030263

Mevastatin

CAS: 73573-88-3

Mevastatin

Purezza: ≥95%

Peso molecolare: 390.51g/mol

Ref: 54-BUP14954

Mevastatin (Compactin)

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 390.52

Ref: 4Z-M-691

Mevastatin

Prodotto controllato

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Colore e forma: Neat

Peso molecolare: 390.51

Ref: 86-MM0377.00

Mevastatin

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Colore e forma: Neat

Peso molecolare: 390.51

Ref: 04-C15219000

Mevastatin

Prodotto controllato

CAS: 73573-88-3

Applications A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.
References Endo, A., et al.: FEBS Letters, 72, 323 (1976), Endo, A.: J. Med. Chem., 28, 401 (1985)

Formula: C₂₃H₃₄O₅

Colore e forma: White To Off-White

Peso molecolare: 390.51

Ref: TR-M340500

Mevastatin - Bio-X ™

CAS: 73573-88-3

Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.

Formula: C₂₃H₃₄O₅

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 390.51 g/mol

Ref: 3D-BM164666

Mevastatin

CAS: 73573-88-3

Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity. In addition, it has been shown to induce neuronal death in a polymerase chain reaction assay by inhibiting DNA synthesis.

Formula: C₂₃H₃₄O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 390.51 g/mol

Ref: 3D-FM25991

Mevastatin

CAS: 73573-88-3

M02108 - Mevastatin

Formula: C₂₃H₃₄O₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 390.52

Ref: 10-M02108

Pravastatin Deshydroxy Impurity

CAS: 73573-88-3

Formula: C₂₃H₃₄O₅

Peso molecolare: 390.52

Ref: ST-EA-CP-P52009