CAS 740816-86-8

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-esaidro-10-idrossi-9-metil-1-osso-9,13-epossi-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pirrolo[3,4-j][1,7]benzodiazonin-11-il]-N-metil-

Descrizione:

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-esaidro-10-idrossi-9-metil-1-osso-9,13-epossi-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pirrolo[3,4-j][1,7]benzodiazonin-11-il]-N-metil- è un composto organico complesso caratterizzato dalla sua struttura intricata, che include più sistemi di anelli fusi e gruppi funzionali. La presenza di un gruppo benzamide indica che contiene un gruppo funzionale amide attaccato a un anello di benzene, contribuendo alla sua potenziale attività biologica. La stereochimica, denotata dalle configurazioni specifiche in vari centri chirali, suggerisce che il composto possa mostrare interazioni uniche nei sistemi biologici. I suoi gruppi esahidro ed epossido implicano una reattività e stabilità potenziali in determinate condizioni. Il peso molecolare del composto, la solubilità e il punto di fusione dipenderebbero dalle sue caratteristiche strutturali specifiche, influenzando il suo comportamento in vari ambienti chimici. Data la sua complessità, questa sostanza potrebbe essere di interesse nella chimica medicinale, in particolare nello sviluppo di farmaci o come strumento di ricerca negli studi biochimici.

Formula: C₃₄H₂₈N₄O₄

Sinonimi:

• O-Desmethyl PKC412
• O-Desmethyl Midostaurin (CGP62221)
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Midostaurin Impurity 2 (O-Desmethyl Midostaurin)
• CGP62221
• O-Desmethyl Midostaurin

O-Desmethyl Midostaurin-d5 (CGP62221-d5)

CAS: 740816-86-8

Formula: C₃₄H₂₃D₅N₄O₄

Peso molecolare: 561.65

Ref: 4Z-M-160006

O-Desmethyl Midostaurin (CGP62221)

CAS: 740816-86-8

Formula: C₃₄H₂₈N₄O₄

Colore e forma: Pale Yellow Solid

Peso molecolare: 556.62

Ref: 4Z-M-160003

O-Desmethyl Midostaurin

CAS: 740816-86-8

Stability Hygroscopic
Applications O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₃₄H₂₈N₄O₄

Colore e forma: Neat

Peso molecolare: 556.61

Ref: TR-D291400

O-Desmethyl Midostaurin-13C6

Prodotto controllato

CAS: 740816-86-8

Applications O-Desmethyl Midostaurin-13C6 is the labelled analogue of O-Desmethyl Midostaurin (D291400), a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₂₈₁₃C₆H₂₈N₄O₄

Colore e forma: Neat

Peso molecolare: 562.57

Ref: TR-D291402

O-Desmethyl Midostaurin-d5

Prodotto controllato

CAS: 740816-86-8

Applications O-Desmethyl Midostaurin-d5 is a deuterium labelled derivative of O-Desmethyl Midostaurin (D291400(M)). O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. O-Desmethyl Midostaurini is also an active metabolite involved in cytochrome P450 liver enzyme metabolism.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012); Levis, M., et al.: NLM, 108, 3477 (2006)

Formula: C₃₄D₅H₂₃N₄O₄

Colore e forma: Neat

Peso molecolare: 561.641

Ref: TR-D291401

o-Desmethyl midostaurin-13C6

CAS: 740816-86-8

Midostaurin is a therapeutic agent for the treatment of chronic myeloid leukemia. It belongs to the family of inhibitors that bind to ion channels and inhibit their activity. The drug has been shown to be an inhibitor of potassium channels, calcium channels, and sodium channels. Midostaurin has been found to bind to the receptor activator of nuclear factor kappa-B ligand (RANKL) on cells in culture, which may contribute to its anti-inflammatory effects.

Formula: C₃₄H₂₈N₄O₄

Purezza: Min. 95%

Peso molecolare: 556.6 g/mol

Ref: 3D-QEB81686

O-Desmethyl Midostaurin

CAS: 740816-86-8

Formula: C₃₄H₂₈N₄O₄

Peso molecolare: 556.62

Ref: ST-EA-CP-M107001

O-Desmethyl Midostaurin

CAS: 740816-86-8

O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.

Formula: C₃₄H₂₈N₄O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 556.61

Ref: TM-T12280