CAS 74150-27-9
:Pimobendan
Descrizione:
Pimobendan è un composto farmaceutico utilizzato principalmente in medicina veterinaria, in particolare per il trattamento dell'insufficienza cardiaca congestizia nei cani. Funziona come un agente inotropo positivo, migliorando la contrattilità del cuore, e agisce anche come un vasodilatatore, che aiuta a ridurre il carico di lavoro del cuore. La struttura chimica di Pimobendan include un nucleo di benzazepina ed è classificato come un inibitore della fosfodiesterasi III, il che contribuisce al suo meccanismo d'azione aumentando i livelli di AMP ciclico intracellulare. Questo si traduce in un miglioramento della gittata cardiaca e in una riduzione della congestione polmonare. Pimobendan viene tipicamente somministrato per via orale ed è ben assorbito, con una emivita relativamente lunga, che consente una somministrazione una o due volte al giorno. Il suo profilo di sicurezza è generalmente favorevole, sebbene gli effetti collaterali potenziali possano includere disturbi gastrointestinali e aritmie. Come medicinale veterinario, è fondamentale utilizzare Pimobendan sotto la guida di un veterinario per garantire una dosaggio appropriato e il monitoraggio della risposta dell'animale al trattamento.
Formula:C19H18N4O2
InChI:InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChI key:InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES:CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1
Sinonimi:- (±)-Ud Cg 115Bs
- 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- Acardi
- Pimobenda
- Racemic pimobendan
- Ud Cg 115 Bs
- Ud-Cg 115
- Vetmedin
- Vedi altri sinonimi
Ordinare per
Purezza (%)
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100
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50
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90
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95
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100
16 prodotti.
Pimobendan
CAS:PimobendanFormula:C19H18N4O2Purezza:99.5%Colore e forma:WhitePeso molecolare:334.14298PIMOBENDAN CRS
CAS:<p>PIMOBENDAN CRS</p>Formula:C19H18N4O2Colore e forma:PowderPeso molecolare:334.3718Pimobendan
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFormula:C19H18N4O2Colore e forma:White Yellow PowderPeso molecolare:334.14298Pimobendan
CAS:<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formula:C19H18N4O2Purezza:99.91%Colore e forma:SolidPeso molecolare:334.376-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One
CAS:6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-OneFormula:C19H18N4O2Purezza:99%Colore e forma: white to almost white crsytal to powderPeso molecolare:334.37g/molPimobendan 100 µg/mL in Acetonitrile
CAS:Formula:C19H18N4O2Colore e forma:Single SolutionPeso molecolare:334.37Pimobendan
CAS:Formula:C19H18N4O2Purezza:>98.0%(T)(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:334.38Pimobendan-d3
CAS:Prodotto controllato<p>Applications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Formula:C19H15D3N4O2Colore e forma:White To Light YellowPeso molecolare:337.39rac Pimobendan
CAS:Prodotto controllato<p>Applications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Formula:C19H18N4O2Colore e forma:NeatPeso molecolare:334.37Pimobendan
CAS:<p>Pimobendan is a drug that has been shown to have positive effects on the cardiac function of experimental animals. It is a selective inhibitor of the enzyme phosphodiesterase 3 in cardiac tissues. Pimobendan also has effects on blood pressure, as it increases systolic pressure and decreases diastolic pressure. The pharmacokinetic properties of pimobendan are characterized by a concentration-time curve with a long terminal half-life. Pimobendan is also an ATP-sensitive K+ channel blocker, which causes increased intracellular K+ concentrations in the myocardium. This leads to an increase in cardiac contractility and relaxation, with an improvement in cardiac performance. Chronic oral administration of pimobendan has been shown to be effective in improving the long-term efficacy of treatment for congestive heart failure due to chronic valvular disease or dilated cardiomyopathy.</p>Formula:C19H18N4O2Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:334.37 g/mol
![6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1011940.jpg&w=3840&q=75)
