CAS 74863-84-6

Argatroban

Descrizione:

Argatroban è un inibitore diretto della trombina sintetico utilizzato principalmente come anticoagulante in contesti clinici, in particolare per pazienti con trombocitopenia indotta da eparina (HIT). È una piccola molecola che si lega selettivamente al sito attivo della trombina, impedendo la conversione del fibrinogeno in fibrina, che è cruciale nel processo di coagulazione. Argatroban viene somministrato per via endovenosa e ha un rapido inizio d'azione, rendendolo adatto per situazioni acute. La sua farmacocinetica è caratterizzata da una breve emivita, necessitando di infusione continua per un'anticoagulazione sostenuta. La sostanza viene metabolizzata principalmente nel fegato e i suoi effetti possono essere monitorati utilizzando test di tempo di tromboplastina parziale attivata (aPTT). Gli effetti collaterali comuni includono complicazioni emorragiche, che sono un rischio associato a tutti gli anticoagulanti. Argatroban è anche notevole per la sua mancanza di reattività crociata con l'eparina, rendendolo una scelta preferita per i pazienti con una storia di HIT. In generale, il suo meccanismo e le sue proprietà uniche lo rendono un importante agente terapeutico nella gestione dei disturbi trombotici.

Formula: C₂₃H₃₆N₆O₅S

InChI: InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1

InChI key: InChIKey=KXNPVXPOPUZYGB-IOVMHBDKSA-N

SMILES: S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3

Sinonimi:

• (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid
• (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
• (2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
• (2R,4R)-1-[N~5~-(diaminomethylidene)-N~2~-{[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-ornithyl]-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-4-Methyl-1-[N-[(3-Methyl-1,2,3,4-Tetrahydro-8-Quinolinyl)Sulfonyl]-L-Arginyl]-2-Piperidinecarboxylic Acid
• 2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, (2R-(1(S*(R*)),2alpha,4beta))-
• 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-
• 2-Piperidinecarboxylic acid, 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, [2R-[1(2S*),2α,4β]]-[partial]-
• 21R-
• Acova
• Argatra
• Argatroban
• Argatroban Monohydrate
• Argipidin
• Argipidine
• Dk 7419
• Gn 1600
• Gn1600
• Mci 9038
• Md 805
• Novastan
• Om 805
• Slonnon

Argatroban Monohydrate

CAS: 141396-28-3, 74863-84-6

Formula: C₂₃H₃₆N₆O₅S·H₂O

Purezza: >99.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 526.66

Ref: 3B-A2705

(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

CAS: 74863-84-6

Formula: C₂₃H₃₆N₆O₅S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 508.6341

Ref: IN-DA0038G0

Argatroban (Mixture of Diastereomers)

CAS: 74863-84-6

Formula: C₂₃H₃₆N₆O₅S

Colore e forma: White To Off-White Solid

Peso molecolare: 508.64

Ref: 4Z-A-591

Argatroban

CAS: 74863-84-6

Argatroban

Purezza: ≥98%

Peso molecolare: 508.63g/mol

Ref: 54-BUP15629

Argatroban

CAS: 74863-84-6

Formula: C₂₃H₃₈N₆O₆S

Purezza: (HPLC) ≥ 98%

Colore e forma: White to off-white powder

Peso molecolare: 526.65

Ref: 7W-GP6176

Argatroban

CAS: 74863-84-6

Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.

Formula: C₂₃H₃₆N₆O₅S

Purezza: 99.77% - >99.99%

Colore e forma: White To Off-White Crystalline Solid

Peso molecolare: 508.63

Ref: TM-T0155

Argatroban

Prodotto controllato

CAS: 74863-84-6

Applications Synthetic thrombin inhibitor. Antithrombotic.
References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),

Formula: C₂₃H₃₆N₆O₅S

Colore e forma: White Powder

Peso molecolare: 508.63

Ref: TR-A769000

Argatroban

CAS: 74863-84-6

Argatroban is a drug that belongs to the group of anticoagulants and is used in the treatment of blood disorders. Argatroban is an oral prodrug that undergoes hepatic metabolism to its active form, argatroban. Argatroban is a thrombin inhibitor that competes with heparin for binding to antithrombin III and thrombin, thereby preventing the formation of fibrin clots. Argatroban has been shown to be successful in treating patients with congestive heart failure or nephrology dialysis who are at risk for developing deep vein thrombosis. This drug also has a long half-life and does not require frequent monitoring, making it suitable for use in these patient populations. However, argatroban should not be used if there is hepatic impairment or if the patient has undergone recent cerebral surgery due to the risk of brain infarction.

Formula: C₂₃H₃₆N₆O₅S

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 508.64 g/mol

Ref: 3D-FA17976