CAS 75-77-4

Clorotrimetilsilano

Descrizione:

Clorotrimetilsilano, con il numero CAS 75-77-4, è un composto organosiliconico caratterizzato dalla presenza di un atomo di silicio legato a tre gruppi metilici e un atomo di cloro. È un liquido incolore a giallo pallido con un odore pungente, ed è noto per la sua reattività, in particolare come agente clorurante e fonte di gruppi trimetilsililici nella sintesi organica. Il composto è tipicamente utilizzato nella preparazione di eteri sililici e nella protezione di alcoli e ammine durante le reazioni chimiche. Clorotrimetilsilano è anche utilizzato nella produzione di polimeri di silicone e come reagente in varie trasformazioni chimiche. È importante maneggiare questa sostanza con cura, poiché può essere corrosiva e può rilasciare acido cloridrico durante l'idrolisi. Si raccomandano misure di sicurezza adeguate, inclusi guanti e occhiali, quando si lavora con questo composto. La sua volatilità e reattività lo rendono uno strumento prezioso nella chimica organica sintetica, in particolare nel campo delle reazioni di sililazione.

Formula: C₃H₉ClSi

InChI: InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChI key: InChIKey=IJOOHPMOJXWVHK-UHFFFAOYSA-N

SMILES: [Si](C)(C)(C)Cl

Sinonimi:

• Chlortrimethylsilan
• Clorotrimetilsilano
• KA 31 (silane)
• Ka 31
• Ls 260
• Monochlorotrimethylsilane
• Monochlorotrimethylsilicon
• Nsc 15750
• Silane, chlorotrimethyl-
• TMS chloride
• TMSCl
• Tmcs
• Trimethylchlorosilane
• Trimethylchlorsosilane
• Trimethylsilane chloride
• Trimethylsilicon chloride
• Trimethylsilyl chloride
• Tsl 8031

Chlorotrimethylsilane

CAS: 75-77-4

Formula: C₃H₉ClSi

Purezza: >98.0%(GC)

Colore e forma: Colorless to Light yellow to Light orange clear liquid

Peso molecolare: 108.64

Ref: 3B-C0306

Chlorotrimethylsilane, 98%

CAS: 75-77-4

Chlorotrimethylsilane, 98+%, Thermo Scientific Chemicals

Formula: C₃H₉ClSi

Purezza: 98%

Colore e forma: Clear colorless to pale yellow, Liquid

Peso molecolare: 108.64

Ref: 02-A13651

Trimethylchlorosilane, min. 97%

CAS: 75-77-4

Trimethylchlorosilane, min. 97%

Formula: (CH₃)₃SiCl

Purezza: min. 97%

Colore e forma: colorless to pale yellow liq.

Peso molecolare: 108.65

Ref: 08-93-1464

Chlorotrimethylsilane

CAS: 75-77-4

Formula: C₃H₉ClSi

Purezza: ≥ 98%

Colore e forma: Clear, colourless to pale yellow liquid

Peso molecolare: 108.64

Ref: 7W-GK4650

Chlorotrimethylsilane

CAS: 75-77-4

Chlorotrimethylsilane

Formula: C₃H₉ClSi

Purezza: 99%

Colore e forma: clear colourless liquid

Peso molecolare: 108.64206g/mol

Ref: 54-OR10000

Chlorotrimethylsilane

CAS: 75-77-4

Stability Moisture Sensitive
Applications Chlorotrimethylsilane have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis. Chlorotrimethylsilane has been used for silylation and as a protection group in the process of various organic synthesis.
E0
References Casimiro, M., et al.: Org. Lett., 15, 2378 (2013); Lifchits, O., et al.: J. Am. Chem. Soc., 135, 6677 (2013);

Formula: C₃H₉ClSi

Colore e forma: Neat

Peso molecolare: 108.64

Ref: TR-C421755

TRIMETHYLCHLOROSILANE CYLINDER

CAS: 75-77-4

Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
Trimethylchorosilane; Chlorotrimethylsilane; Trimethylsilyl chloride; TMCS
Viscosity: 0.47 cStΔHcomb: -2,989 kJ/molΔHform: -354 kJ/molΔHvap: 27.6 kJ/molDipole moment: 2.09 debyeSurface tension: 17.8 mN/mSpecific heat: 1.76 J/g/°CCoefficient of thermal expansion: 1.2 x 10-3Vapor pressure, 20 °: 190 mmVapor pressure, 50 °C: 591 mmCritical temperature: 224.6 °CCritical pressure: 31.6 atmMost economical and broadly used silylation reagentEnhances Claisen rearrangementEnhances the deprotection of tBOC-protected amino acidsEnhances ethylene glycol ketalization reactionCatalyzes the formation of chlorohydrin esters from diolsReviewed as water scavenger in reactions of carbonyl compoundsFacilitates Michael additionsReacts in presence of HCl acceptorWill silylate strong acids with expulsion of HClHigh purity grade available, SIT8510.1Protects hindered alcohols with Mg/DMFNafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction timesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Formula: C₃H₉ClSi

Purezza: 97%

Colore e forma: Straw Liquid

Peso molecolare: 108.64

Ref: 3H-SIT8510.0

TRIMETHYLCHLOROSILANE, 99+%

CAS: 75-77-4

Formula: C₃H₉ClSi

Purezza: 99%

Colore e forma: Straw Liquid

Peso molecolare: 108.64

Ref: 3H-SIT8510.1

Trimethylchlorosilane

CAS: 75-77-4

Trimethylchlorosilane is a model system for the study of chloride ion transport across lipid membranes. It has been shown that this molecule can form a disulfide bond with glutathione and may have synergistic effects with other drugs, such as metronidazole, to treat bowel disease. Trimethylchlorosilane can also be used in analytical methods for measuring chloride ions in wastewater and other samples. The x-ray crystal structures of trimethylchlorosilane anhydrous sodium salt have been determined at room temperature. The hydrogen fluoride molecule binds to the pyrazole ring and the chlorine atom forms a covalent bond with the hydroxyl group on one of the water molecules. The reaction solution is heated to produce trimethylchlorosilane, which is then cooled to room temperature again, during which time it crystallizes out of solution.

Formula: C₃H₉ClSi

Purezza: Min. 95%

Colore e forma: Clear Liquid

Peso molecolare: 108.64 g/mol

Ref: 3D-FT02586

Trimethyl Chlorosilane (TMCS) extrapure, 99%

CAS: 75-77-4

Formula: C₃H₉CISi

Purezza: min. 99%

Colore e forma: Clear, Colourless to pale yellow, Liquid

Peso molecolare: 108.64

Ref: SR-90265

Trimethyl Chlorosilane (TMCS) extrapure, 98%

CAS: 75-77-4

Formula: C₃H₉ClSi

Purezza: min. 98%

Colore e forma: Clear, Colourless to pale yellow, Liquid

Peso molecolare: 108.64

Ref: SR-20139

Trimethyl Chlorosilane (TMCS) 1M Solution in THF

CAS: 75-77-4

Formula: C₃H₉ClSi

Colore e forma: Clear, Colourless, Liquid

Peso molecolare: 108.64

Ref: SR-67883