CAS 75330-75-5

Lovastatina

Descrizione:

Lovastatina è una statina di origine naturale, utilizzata principalmente come farmaco per abbassare il colesterolo. È derivata dalla fermentazione del fungo Aspergillus terreus. La struttura chimica di Lovastatina presenta un anello di esahidronaftalene e un gruppo lattone, che è cruciale per la sua attività biologica. Come inibitore competitivo della HMG-CoA reduttasi, un enzima coinvolto nella biosintesi del colesterolo, Lovastatina riduce efficacemente i livelli di colesterolo a bassa densità (LDL) nel flusso sanguigno. Viene tipicamente somministrato per via orale ed è noto per la sua relativamente buona biodisponibilità, sebbene subisca un significativo metabolismo di primo passaggio nel fegato. Lovastatina è anche associato a vari effetti collaterali, tra cui dolore muscolare e elevazione degli enzimi epatici, richiedendo un monitoraggio regolare durante il trattamento. Inoltre, può interagire con altri farmaci, evidenziando l'importanza di una storia medica completa prima dell'inizio. In generale, Lovastatina gioca un ruolo significativo nella gestione dell'iperlipidemia e nella riduzione del rischio di malattie cardiovascolari.

Formula: C₂₄H₃₆O₅

InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI key: InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N

SMILES: O(C([C@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Sinonimi:

• (1S,3R,7S,8S)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 6α-Methylcompactin
• 8-[2-(4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Altocor
• Altoprev
• Antibiotic MB 530B
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),3α,7β,8β(2S*,4S*),8aβ]]-
• L 154803
• Lestric
• Lostatin
• Lovacard
• Lovalip
• Lovastatin lactone
• Lovastation
• Lovastin
• Lovex
• Mevacor
• Mevinacor
• Mevinolin
• Mevlor
• Mk 803
• Monacolin K
• Monacolin K lactone
• Msd 803
• Msd803
• NSC 633781
• Oxy)-1-Naphthaleneheptanoicaciddelta-Lactone
• Red Yeast Rice P.E

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 404.55

Ref: 3B-L0214

Lovastatin, 97%

CAS: 75330-75-5

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents

Formula: C₂₄H₃₆O₅

Purezza: 97%

Peso molecolare: 404.56

Ref: 02-H52792

LOVASTATIN CRS

CAS: 75330-75-5

LOVASTATIN CRS

Formula: C₂₄H₃₆O₅

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 404.5396

Ref: 41-L0790000

LOVASTATIN FOR PEAK IDENTIFICATION CRS

CAS: 75330-75-5

LOVASTATIN FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₃₆O₅

Peso molecolare: 404.5396

Ref: 41-Y0001136

Lovastatin

CAS: 75330-75-5

Lactones nesoi

Formula: C₂₄H₃₆O₅

Colore e forma: White Powder

Peso molecolare: 404.54

Ref: 45-1370600

Lovastatin

CAS: 75330-75-5

Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.

Formula: C₂₄H₃₆O₅

Purezza: 99.66% - 99.92%

Colore e forma: The Substance Is A White-Yellowish To Yellow Powder Solid Powder

Peso molecolare: 404.54

Ref: TM-T1207

Lovastatin

CAS: 75330-75-5

Lovastatin

Purezza: 99+%

Colore e forma: Off-White Powder

Peso molecolare: 404.54g/mol

Ref: 54-BIL1008

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to off-white or faint yellow powder

Peso molecolare: 404.56

Ref: 7W-GP4839

Lovastatin

CAS: 75330-75-5

Lovastatin

Purezza: 99%

Peso molecolare: 404.54g/mol

Ref: 54-BI12174

Lovastatin

CAS: 75330-75-5

Lovastatin

Purezza: ≥98%

Peso molecolare: 404.54g/mol

Ref: 54-BUP17172

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 404.55

Ref: 4Z-L-127

Lovastatin, EP grade

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purezza: 97.0 - 102.0 % (dried substance)

Colore e forma: White or almost white crystalline powder

Peso molecolare: 404.56

Ref: 7W-GP2911

Lovastatin

Prodotto controllato

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Colore e forma: Neat

Peso molecolare: 404.54

Ref: 86-MM0050.00

Lovastatin

Prodotto controllato

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Colore e forma: Neat

Peso molecolare: 404.54

Ref: 04-C14648500

Lovastatin

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Purezza: 95%~99%

Colore e forma: White cryst.

Peso molecolare: 404.547

Ref: BP-BP3441

Lovastatin

CAS: 75330-75-5

M02056 - Lovastatin

Formula: C₂₄H₃₆O₅

Purezza: 95%

Colore e forma: Solid, White powder

Peso molecolare: 404.547

Ref: 10-M02056

Monacolin k

CAS: 75330-75-5

Lactone

Formula: C₂₄H₃₆O₅

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 404.55

Ref: 5G-80307

Lovastatin

CAS: 75330-75-5

Impurity Simvastatin EP Impurity E
Applications Lovastatin (Simvastatin EP Impurity E) is an antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase.
References Bilheimer, D.W., et al.: Proc. Nat. Acad. Sci. USA, 80, 4124 (1983),

Formula: C₂₄H₃₆O₅

Colore e forma: White To Light Yellow

Peso molecolare: 404.54

Ref: TR-L472225

Simvastatin EP Impurity E

CAS: 75330-75-5

Formula: C₂₄H₃₆O₅

Peso molecolare: 404.5

Ref: ST-EA-CP-S4024

Lovastatin - Bio-X ™

CAS: 75330-75-5

Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Formula: C₂₄H₃₆O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 404.54 g/mol

Ref: 3D-BL164644

Lovastatin

CAS: 75330-75-5

HMG-CoA reductase inhibitor; mevalonic acid synthesis inhibitor

Formula: C₂₄H₃₆O₅

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 404.54 g/mol

Ref: 3D-FH24950

Lovastatin-d9 (Mixture of Diastereomers)

Prodotto controllato

CAS: 75330-75-5

Applications Lovastatin-d9, is the labeled analogue of Lovastatin (L472225), an antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase.
References Bilheimer, D.W., et al.: Proc. Nat. Acad. Sci. USA, 80, 4124 (1983),

Formula: C₂₄H₂₇D₉O₅

Colore e forma: Neat

Peso molecolare: 413.6

Ref: TR-L472228

Lovastatin

CAS: 75330-75-5

Colore e forma: Neat

Ref: 61-FOR0050.00