CAS 75443-99-1

Acido naftacenecarbossilico, 2-etil-1,2,3,4,6,11-esaidro-2,5,7-triidrossi-6,11-diosso-4-[[2,3,6-trideossi-4-O-[2,6-dideossi-4-O-[(2R,6S)-tetraidro-6-metil-5-osso-2H-pirano-2-il]-α-L-lixo-esopiranosil]-3-(dimetilamino)-α-L-lixo-esopiranosil]ossi]-, estere metilico, cloridrato (1:1), (1R,2R,4S)-

Descrizione:

Acido naftacenecarbossilico, 2-etil-1,2,3,4,6,11-esaidro-2,5,7-triidrossi-6,11-diosso-4-[[2,3,6-trideossi-4-O-[2,6-dideossi-4-O-[(2R,6S)-tetraidro-6-metil-5-osso-2H-pirano-2-il]-α-L-lixo-esopiranosil]-3-(dimetilamino)-α-L-lixo-esopiranosil]ossi]-, estere metilico, cloridrato (1:1), (1R,2R,4S)-, identificato dal numero CAS 75443-99-1, è un composto organico complesso caratterizzato dalla sua intricatissima struttura molecolare, che include più gruppi funzionali come acidi carbossilici, idrossili ed esteri. Questo composto presenta proprietà tipiche dei derivati del naftalene e di strutture simili ai carboidrati, suggerendo una potenziale attività biologica. La sua forma di cloridrato indica che è un sale, il che può migliorare la sua solubilità in soluzioni acquose. La presenza di più stereocentri implica che possa esistere in diverse forme stereoisomeriche, il che può influenzare la sua reattività e interazione con i sistemi biologici. In generale, la struttura unica di questo composto può contribuire alle sue potenziali applicazioni in farmacologia o biochimica, sebbene specifiche attività biologiche e applicazioni richiederebbero ulteriori indagini.

Formula: C₄₂H₅₃NO₁₅·ClH

InChI: InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1

InChI key: InChIKey=KUSMIBXCRZTVML-PCCPLWKKSA-N

SMILES: C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7.Cl

Sinonimi:

• 1-Naphthacenecarboxylic acid, 1,2,3,4,6,11-hexahydro-6,11-dioxo-2-ethyl-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-2,5,7-trihydroxy-, methyl ester, hydrochloride, (1R-(1-alpha,2-beta,4-beta))-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyranosyl)oxy)-, methyl ester, hydrochloride, (1R-(1alpha,2beta,4beta))-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride (1:1), (1R,2R,4S)-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, (1R,2R,4S)-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
• Aclacinomycin A hydrochloride
• Aclacinon
• Aclaplastin
• Aclarubicin HCl
• Aclarubicina clorhidrato
• Aclarubicina clorhidrato [Spanish]
• Unii-501948Ri66
• methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate hydrochloride (1:1)
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride (1:1), (1R,2R,4S)-
• Aclarubicin hydrochloride
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, (1R,2R,4S)-

Aclacinomycin A hydrochloride

CAS: 75443-99-1

Aclacinomycin A hydrochloride

Purezza: ≥95%

Peso molecolare: 848.33g/mol

Ref: 54-BUP21726

Aclacinomycin A hydrochloride

CAS: 75443-99-1

Aclacinomycin A hydrochloride (Aclarubicin HCl) is an antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication,

Formula: C₄₂H₅₄ClNO₁₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 848.33

Ref: TM-T10238

Aclacinomycin hydrochloride

CAS: 75443-99-1

Ref: 7W-GC4572

Aclacinomycin HCl

CAS: 75443-99-1

Aclacinomycin HCl is a cytotoxic antibiotic that inhibits the growth of tumor cells. It has been shown to induce apoptosis in human leukemia cells by altering the transmembrane potential and inhibiting cell proliferation. Aclacinomycin HCl also induces DNA damage response, which leads to caspase activities and cell death. This drug is highly selective for tumor cells, with no effect on normal cells. It has been shown to be effective against primary liver cancer in animal models, as well as developmental disorders such as autism spectrum disorder (ASD).

Formula: C₄₂H₅₃NO₁₅·HCl

Purezza: Min. 95%

Colore e forma: Orange Powder

Peso molecolare: 848.33 g/mol

Ref: 3D-AA16417